Polymorphisms in the GC Gene for Vitamin D Binding Protein and Their Association with Vitamin D and Bone Mass in Young Adults

Khan, Aysha Habib; Jafri, Lena; Siddiqui, Areeba; Naureen, Ghazala; Morris, Howard A.; Moatter, Tariq

doi:10.29271/jcpsp.2019.08.715

Cited by 11 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To extract this detailed information from all included studies caused the rather long duration from the underlying systematic search to reporting the results. However, no conflicting results were found when comparing the outcomes of our study to recently published data [ 121 , 122 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 ]. The focus of recently published data remains in the same gene’s polymorphisms: GC, CYP2R1, VDR, CYP24A1, and CYP27B1.…”

Section: Discussioncontrasting

confidence: 78%

Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

An association between vitamin D level and muscle-related traits has been frequently reported. Vitamin D level is dependent on various factors such as sunlight exposure and nutrition. But also on genetic factors. We, therefore, hypothesize that single nucleotide polymorphisms (SNPs) within the vitamin D pathway-related genes could contribute to muscle mass and function via an impact on vitamin D level. However, the integration of studies investigating these issues is still missing. Therefore, this review aimed to systematically identify and summarize the available evidence on the association between SNPs within vitamin D pathway-related genes and vitamin D status as well as various muscle traits in healthy adults. The review has been registered on PROSPERO and was conducted following PRISMA guidelines. In total, 77 studies investigating 497 SNPs in 13 different genes were included, with significant associations being reported for 59 different SNPs. Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies. Various muscle traits have been investigated only in relation to four different vitamin D receptor (VDR) polymorphisms (rs7975232, rs2228570, rs1544410, and rs731236). Interestingly, all of them showed only very low confirmation rates (6–17% of the studies). In conclusion, this systematic review presents one of the most comprehensive updates of the association of SNPs in vitamin D pathway-related genes with vitamin D status and muscle traits in healthy adults. It might be used for selecting candidate SNPs for further studies, but also for personalized strategies in identifying individuals at risk for vitamin D deficiency and eventually for determining a potential response to vitamin D supplementation.

show abstract

Section: Discussioncontrasting

confidence: 78%

Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…DBP alleles differ in their affinity with the vitamin D metabolites and can have substantial impact on various clinical conditions 4 . Polymorphisms in the DBP gene have been reported to be associated with vitamin D deficiency in different populations 12,18,19 . The general prevalence of vitamin D deficiency varies in the world, ranging from 7% to 77% 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Polymorphisms in the DBP gene have been reported to be associated with vitamin D deficiency in different populations. 12,18,19 The general prevalence of vitamin D deficiency varies in the world, ranging from 7% to 77%. 20 polymorphisms were recently described in human populations.…”

Section: Discussionmentioning

confidence: 99%

The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

Batur

Hekim

2020

Journal of Medical Virology

View full text Add to dashboard Cite

Since December 2019, coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has given rise to emerging respiratory infections with pandemic diffusion. The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels participate in various clinical conditions. The main goal of this study was to evaluate if there was any association between the DBP gene polymorphism at rs7041 and rs4588 loci and the prevalence of COVID‐19 and its mortality rates caused among populations of 10 countries including Turkey. Positive significant correlations were found between the prevalence (per million) and mortality rates (per million), and GT genotype ( P < .05) while there was a negative significant correlation between prevalence (per million) and mortality rates (per million), and TT genotype at rs7041 locus among all populations ( P < .05). However, no significant correlation was found at rs4588 locus. GT genotype was found to confer this susceptibility to the populations of Germany, Mexico, Italy, Czech, and Turkey. The variations in the prevalence of COVID‐19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588 .

show abstract

“…1 It has been now established that Vitamin D serves as an active hormone acting as a transcription factor that regulates the function of more than 200 genes. 2,3 Vitamin D deficiency leads to many chronic including autoimmune disorders, obesity, Type-2 diabetes, cardiovascular events, various types of cancers, adverse pregnancy outcomes, metabolic syndrome, and increases the risk of mortality due to associated complications. 4 Vitamin D deficiency worldwide is a public health problem at present, as it becoming increasing common due to sedentary lifestyle, limited exposure to the sunlight and aging.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vitamin D inadequacy in asymptomatic population.

Jabbar

Unar²,

Khan³

et al. 2020

TPMJ

View full text Add to dashboard Cite

Objectives: The aim of study was to determine vitamin d deficiency in age and sex groups associated with different regions. Therefore, this diagnostic method has played an important role in the prevention of various medical conditions. Study Design: Cross-sectional study. Setting: Department of Obstetrics and Gynaecology, Gambat Institute of Medical Sciences Gambat, Khairpur Sindh. Period: 14 August 2016 to 24 February 2018. Material & Methods: Total 1924 participants were screened and included in the study by fulfilling the inclusion criteria. Exclusion criteria were signs and symptoms of any chronic disease, active injury, abnormal liver function or any chronic kidney and pregnancy problem. All participants who met the inclusion and exclusion criteria were interviewed after taking informed consent. Questionnaires for the study were prepared and distributed to the selected population. According to the questionnaire and interviews by the researchers, details of lifestyles, social status, and monthly income were reported. Moreover, marital status, milk in take, and sun exposure hours were also asked. Blood sample of each participant was taken after taking written informed consent form. A total 1924 people screened for Vitamin D levels with help of direct chemiluminescence using ADVIA Centaur assay. Results: 1924 people from five different regions of Gambat. A total of 1153 (59.9%) people with vitamin D deficiency were found, while 724 showed normal rates and 47 found to be larger than normal. Females are more deficient for vitamin D (35.7%) than males (24.4%). Conclusion: The high population without symptoms with low levels Vitamin D is an alarming sign of deteriorating health, while multiple risk factors appear.

show abstract

Polymorphisms in the GC Gene for Vitamin D Binding Protein and Their Association with Vitamin D and Bone Mass in Young Adults

Abstract: Objective: To determine the effectiveness of direct observation of procedural skills (DOPS) in the assessment and improving operative skills of postgraduate residents in urology. Study Design: Comparative study.

Cited by 11 publications

References 0 publications

Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review

Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review

The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

Prevalence of vitamin D inadequacy in asymptomatic population.

Contact Info

Product

Resources

About