Polymorphisms in the Melatonin Receptor 1B Gene and the Risk of Delirium

Jonghe, Annemarieke de; Rooij, S de; Tanck, Michael W.T.; Sijbrands, Eric J.G.; Munster, Barbara C. Van

doi:10.1159/000339231

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…However, the analysis yielded 93% of subjects having the minor allele calling into question the methods or generalizability of that sample population. [ 19 ]…”

Section: Introductionmentioning

confidence: 99%

Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium?

et al. 2018

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IntroductionPatients undergoing cardiac surgery are at high risk for postoperative delirium, which is associated with longer hospital and intensive care lengths of stays, increased morbidity and mortality. Because sleep disturbances are common in delirium, melatonin has been an area of interest in the treatment of delirium. The rs10830963 single nucleotide polymorphism of the melatonin receptor 1B gene can cause pathological dysfunction of this receptor and is associated with delayed morning offset of melatonin. We hypothesized patients undergoing aortic cardiac surgery who have the risk genotype of a melatonin receptor 1B polymorphism would have a higher incidence of postoperative delirium.MethodsNinety-eight patients undergoing aortic root or valve surgery underwent analysis for melatonin receptor 1B single nucleotide polymorphism, rs10830963. Using a validated method, CHART-DEL, all charts were retrospectively reviewed and scored for the presence of delirium while blinded to the results of the melatonin receptor 1B gene polymorphism.ResultsGenotyping for melatonin receptor 1B polymorphism was acceptable in 76 subjects of European descent of which 18 (23.7%) had delirium. Four of seven subjects with the risk genotype had delirium versus only 20.3% of subjects without the risk genotype. This carried an odds ratio of 5.2 (1.0, 26.1), p = 0.050.ConclusionThis observation suggests a role of the risk genotype of a melatonin receptor 1B polymorphism in the development of postoperative delirium. These hypotheses generating results warrant further prospective studies in a larger cohort group with delirium, circadian rhythm and melatonin assessments.

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“…However, the analysis yielded 93% of subjects having the minor allele calling into question the methods or generalizability of that sample population. [ 19 ]…”

Section: Introductionmentioning

confidence: 99%

Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium?

et al. 2018

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“…Another study was done on the association between MTN1B and occurrence of delusions (a sign of SCZ) by A de Jonghe et al, showing that neither rs10830962 nor rs3781638 polymorphisms were associated with the occurrence of delusions (20).…”

Section: Discussionmentioning

confidence: 99%

Melatonin Receptor 1B Gene Polymorphisms, Haplotypes and Susceptibility to Schizophrenia

Saravani

Esmaeilzaei

Noorzehi

et al. 2017

Revista Romana De Medicina De Laborator

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Melatonin has an important role in the regulation of human sleep circadian rhythms. Sleep disturbances commonly exist in schizophrenia (SCZ) patients. To begin its performance, melatonin must interact to its receptor. In the present study, Single Nucleotide Polymorphisms (SNPs) of melatonin receptor gene 1 B (MTN1B) with SCZ development in Iranian population were investigated. The current case-control study was performed on 92 SCZ patients and 92 healthy control (HC) subjects. NESTED-PCR and ARMS-PCR modified methods (combination) and ARMS-PCR method were used on the genotype. The impact of MTN1B rs3781637 (T/C) and rs10830963(C/G) polymorphism variants on the risk SCZ in the sample of Iranian population was investigated. The findings showed significant association between MTN1B rs10830963(C/G) variant and SCZ (OR=2.78, P=0.012, GG vs. CC, OR=1.66, P=0.021 G vs. C, P<0.0001, GG vs. CC+CG). There was no association between MTN1B rs3781637 (T/C) and SCZ risk. In addition, haplotype analysis revealed that TG and CC haplotype of rs3781637 (T/C) and rs10830963 (C/G) polymorphisms

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