2022
DOI: 10.1007/s10072-022-06226-1
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Polymorphisms in the oxytocin receptor and their association with apathy and impaired social cognition in Huntington’s disease

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Cited by 4 publications
(6 citation statements)
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“…44,45 Genetic variations of OXTR have recently been shown to influence the prevalence of social impairment in HD patients. 46 The effects of manipulation of mHTT expression in OXTRexpressing neurons would, therefore, be interesting to explore.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…44,45 Genetic variations of OXTR have recently been shown to influence the prevalence of social impairment in HD patients. 46 The effects of manipulation of mHTT expression in OXTRexpressing neurons would, therefore, be interesting to explore.…”
Section: Discussionmentioning
confidence: 99%
“…OXT receptors (OXTRs) have been found in many other brain regions of the limbic system involved in emotional control and cognition, including the amygdala and prefrontal cortex 44,45 . Genetic variations of OXTR have recently been shown to influence the prevalence of social impairment in HD patients 46 . The effects of manipulation of mHTT expression in OXTR‐expressing neurons would, therefore, be interesting to explore.…”
Section: Discussionmentioning
confidence: 99%
“…In a previous study, we found a possible association between apathy and impaired social cognition and some polymorphisms in the oxytocin receptor coding gene ( OXTR ) that might be some evidence of hypothalamic degeneration in HD, leading to oxytocinergic dysfunction in HD and its association with neuropsychiatric manifestations [ 93 ]. Polymorphisms in the oxytocin receptor could have a relevant role in the correct development of social and cognitive functions.…”
Section: Other Biomarkers In Studymentioning
confidence: 99%
“…Polymorphisms in the oxytocin receptor could have a relevant role in the correct development of social and cognitive functions. We found various OXTR -synonymous variants that warrant further study for their involvement in apathy, irritability, and social cognition in HD [ 93 ].…”
Section: Other Biomarkers In Studymentioning
confidence: 99%
“…Interestingly, in a recent study, distinct OXTR expression patterns have been shown in psychiatric disorders as well as in metabolic regulation processes across development in humans ( Rokicki et al, 2022 ). Furthermore, genetic variation of OXTR has also been shown to be associated with social impairment in HD ( Saiz-Rodríguez et al, 2022 ). When exogenously administered, OXT facilitates social encounters, improved social cognitive outcomes as well as emotion recognition in healthy and clinical groups characterized by social deficits, such as autism and social anxiety disorder ( Heinrichs et al, 2009 ; Keech et al, 2018 ).…”
Section: Introductionmentioning
confidence: 99%