Polymorphisms in VDR gene in Tunisian postmenopausal women are associated with osteopenia phenotype

Sassi, R.; Sahli, H.; Souissi, C.; Sellami, Slaheddine; Gaaied, Amel Ben Ammar El

doi:10.3109/13697137.2015.1007123

Cited by 16 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a large cohort of Iranians, Fok1 A/G (rs2228570) polymorphism was significantly associated with OP in postmenopausal women [45]. Sassi et al [46] analyzed the association of other VDR polymorphisms (ApaI and TaqI) with BMD in postmenopausal Tunisian women and an increased risk to develop osteopenia, but not OP, was shown which strengthens the hypothesis that OP results from the interaction of genetic and environmental factors. The relationship of the 21 single nucleotide polymorphisms (SNP) in 7 selected candidate genes (LRP5, RANK, RANKL, ESR1, VDR, P2XR7, and OPG) with BMD at different body sites was evaluated in an Iranian population [47].…”

Section: Non-modifiable Risk Factors Modifiable Risk Factorsmentioning

confidence: 75%

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

Hammam¹

2018

Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

Background: Osteoporosis (OP) is defined by low bone mass and microstructural deterioration. It is an escalating public health problem due to increase life expectancy and the resulting bone fractures represent a significant burden for both the individual and the society in terms of morbidity, mortality and cost. Osteoporosis, a multifactorial disease, results from the interaction between genetic and environmental risk factors. Currently, the data available regarding OP epidemiology and predisposing risk factors differ greatly between regions and within population ethnicities. Proper estimation of the epidemiology of OP and its health related outcomes can help identity those at risk and permit prophylactic treatment before its occurrence. The main barrier towards disease prevention strategies is the impaired awareness of the disease and its risk. Enhanced understanding of the OP disease may influence personal behaviors and reduce its prevalence.Objectives: This review was undertaken to wrap-up and throw-light on the published literatures related to the epidemiology of osteoporosis in the Middle East and North Africa (MENA) region, and expose the extent of awareness in the corresponding populations. Describing and discussing key points on the current state of knowledge on these hot issues are well thought-out.Conclusion: Osteoporosis prevalence is variable among MENA populations. Limited reports regarding the established prevalence of osteoporotic fractures among those populations and therefore, lack of guidelines for prevention and management were noticed. In order to improve bone health, preventive measures against OP should be considered. Increase OP awareness and preventive practices in the societies as part of the prophylactic strategy need to be initiated.

show abstract

Section: Non-modifiable Risk Factors Modifiable Risk Factorsmentioning

confidence: 75%

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

Hammam¹

2018

Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

show abstract

“…Aa (ApaI) genotype was considered as a protective factor against osteoporosis while aa genotype was considered as an osteopenic factor related to bone fractures. In addition, Aa/TT genotype (ApaI/TaqI) was the major haplotype in individuals with normal bone mass (27). In Belarusian osteoporetic menopausal women, ApaI, TaqI, and BsmI polymorphisms were found to be an influencing factors of osteoporosis (28).…”

Section: Discussionmentioning

confidence: 99%

The relationship between vitamin D receptor (VDR) polymorphism and the occurrence of osteoporosis in menopausal Iranian women

Dabirnia

Mahmazi

Taromchi

et al. 2016

ccmbm

View full text Add to dashboard Cite

SummaryBackground. Osteoporosis, a multifactorial disease with reduced bone mineral density which increases the probability of bone fractures, is caused by calcium deficiency, and its incidence increases with age. It has been determined that mutations in functional regions of vitamin D receptor gene will affect the metabolism of minerals especially calcium and, therefore, bone density. The present study evaluates the relation between vitamin D receptor polymorphisms, TaqI (rs731236) and ApaI (rs7975232), and osteoporosis in menopausal Azari women in Zanjan province. Materials and methods. This case-control study has been conducted on 50 menopausal women suffering from osteoporosis and 50 menopausal women who did not suffer from osteoporosis in Zanjan province. The diagnosis of osteoporosis was confirmed using DEXA instrument. Peripheral blood was collected from the subjects and controls to extract DNA and assess the ApaI and TaqI polymorphisms using PCR-RFLP method. The results were interpreted using independent T-test, chi-square, and Pearson correlation coefficient with a p-value less than 0.05. Results. There was not a significant difference between the frequency of ApaI (AA/Aa/aa) and TaqI (TT/Tt/tt) genotypes in cases (mean age 68.72) and controls (mean age 64.7) (p=0.37 and p=0.64, respectively). In addition, ApaI/TaqI allele haplotype in osteoporotic population showed non-significant relation (p value=0.563) compared with the control group. Discussion and conclusion. The relationship between the genotypes and osteoporosis, cancers, and mineral metabolism disorders has been studied for a long time. Although there has been a significant relation between the aforementioned genotypes and osteoporosis or reduced mineral density-related bone fractures in some studied, some other studies have opposing results. Therefore, it is only possible to reach an acceptable conclusion by studying the haplotype of the polymorphisms in subjects.

show abstract

“…For BsmI total 65 studies with 6,880 cases and 8,049 controls were found eligible to include in the meta-analysis . For ApaI total 31 studies with 3,763 cases and 3,934 controls were found to be eligible to include in the meta-analysis [19,23,25,33,39,40,43,46,51,58,59,61,64,66,68,70,72,74,76,[78][79][80][82][83][84][85][86][87][88][89][90]. For FokI meta-analysis total 18 studies with 1,895 cases and 1,722 controls were found eligible to include in the meta-analysis [33, 40,45,51,56,62,65,66,68,70,74,76,79,[91][92][93][94][95].…”

Section: Eligible Studiesmentioning

confidence: 99%

Vitamin D receptor (VDR) geneFokI,BsmI,ApaI andTaqI polymorphisms and osteoporosis risk: a meta-analysis

Yadav

Kumar

Rai

2019

Preprint

View full text Add to dashboard Cite

Osteoporosis is a bone disease characterized by low bone density. The prevalence of osteoporosis varies between different populations and ethnic groups. Numerous studies have investigated the relationship between VDR gene polymorphisms and osteoporosis across ethnic populations. Present meta-analysis aims to comprehensively evaluate the influence of common FokI, BsmI, ApaI and TaqI VDR gene polymorphisms and osteoporosis. PubMed, Google Scholar, Springer Link and Elsevier databases were searched for eligible studies and all statistical calculations were performed by Open Meta-Analyst software. Studies investigated BsmI (65 studies; 6,880 case/ 8,049 control), ApaI (31 studies; 3,763 case/ 3,934 control), FokI (18 studies; 1,895 case/ 1,722 control), and TaqI (26 studies; 2,458 case/ 2,895 control) polymorphisms were included in the present meta-analysis. Results of meta-analysis revealed significant association between dominant model of FokI (OR ff+Ff vs. FF = 1.19, 95% CI= 1.04-1.36, p= 0.01, I 2 = 39.36%) in overall analysis and recessive model of Caucasian population of TaqI polymorphism (OR TT+Tt vs. tt = 1.35, 95% CI= 1.11-1.63, p= 0.002, I 2 = 50.07%). While no such effect is found in any other genetic model in any other gene polymorphisms of the overall analyses or sub-group analyses. In conclusion, we found the FokI polymorphism is associated with osteoporosis in overall analysis, also the TaqI polymorphism is a risk factor for the Caucasian population.

show abstract

Polymorphisms in VDR gene in Tunisian postmenopausal women are associated with osteopenia phenotype

Cited by 16 publications

References 36 publications

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

The relationship between vitamin D receptor (VDR) polymorphism and the occurrence of osteoporosis in menopausal Iranian women

Vitamin D receptor (VDR) geneFokI,BsmI,ApaI andTaqI polymorphisms and osteoporosis risk: a meta-analysis

Contact Info

Product

Resources

About