Polymorphisms of DRD2 and DRD3 genes and Parkinson’s disease: A meta-analysis

Abstract

Abstract. Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects ~2% of the population aged ≥65 years. The degeneration of dopamine neurons in the substantia nigra contributes to the pathogenesis of PD. Dopamine receptor D2 (DRD2) and dopamine receptor D3 (DRD3) are two key subtypes of dopamine receptors. The aim of our study was to evaluate the association between the polymorphisms of DRD2 and DRD3 genes and PD. Meta-analyses were conducted from 16 studies (46 stages) among 4,279 cases and 5,661 controls between PD and 9 polymorphisms (DRD2: rs1800497, rs1079597, rs6278, rs6279, rs273482, rs1799732 and rs1076563; DRD3: rs6280 and rs2134655). A significant association was observed between DRD3 rs2134655 polymorphism and PD [P=0.01, odds ratio (OR)=1.17, 95% confidence interval (CI): 1.03-1.32] and a borderline association was observed between DRD2 rs1800497 polymorphism and PD in Europeans (P=0.05, OR=1.13, 95% CI: 1.00-1.27). Findings of the current meta-analysis suggested that DRD3 rs2134655 polymorphism was associated with a 17% increased risk of PD and that DRD2 rs1800497 polymorphism had a potential to increase the risk of PD by 13% in Europeans. Future large-scale studies are required to confirm the ethnic difference of DRD2 rs1800497 polymorphism and to determine whether there were significant associations of PD with other polymorphisms in DRD2 and DRD3 genes.

Association of BDNF and BCHE with Alzheimer's disease: Meta-analysis based on 56 genetic case-control studies of 12,563 cases and 12,622 controls

“…Discrepancies among the previous association studies may have been the result of limited power, different ethnic backgrounds or the different processes and status in patients with AD. Meta-analysis can strengthen the power by combining data from different studies and can draw a more comprehensive conclusion by analyzing studies in different ethnicities (73)(74)(75). The aim of the current meta-analysis was to assess the association between the three polymorphisms and AD.…”

The association of the DRD3 gene with Parkinson’s disease

“…D. Dai и соавт. [11] провели метаанализ, в котором были проанализированы ассоциации полиморфизмов генов DRD2 и DRD3 с БП в 16 зарубежных работах, объединяющих 4279 пациентов и 5661 здорового [11]. Метаанализ продемонстрировал достоверную ассоциацию rs1800497 гена DRD2 и rs2134655 гена DRD3 с БП.…”

Association of Parkinson disease age of onset with DRD2, DRD3 and GRIN2B polymorphisms

“…Several case-control studies have reported variable associations of DRD2 polymorphisms with PD risk [3–8]. Certain DRD3 polymorphisms have been associated with PD risk (e.g.…”

“…Certain DRD3 polymorphisms have been associated with PD risk (e.g. rs2134655) [8], while others (e.g. rs6280) [4,5] and the NMDA GRIN2B receptor polymorphisms were not apparently associated with PD risk [6].…”