Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients

Šurbatović, Maja; Grujic, Krasimirka; Cikota, Bojana; Jevtic, Miodrag; Filipović, Nikola; Romic, Predrag; Strelić, Nataša J.; Magić, Zvonko

doi:10.1016/j.jcrc.2009.12.003

Cited by 28 publications

(20 citation statements)

References 34 publications

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“…Similar results were reported from two Brazilian studies with adult patients [18,19]. In contrast, a Japanese study with 123 septic adult patients [46] as well a Serbian study of 106 critically ill patients [47] reported increased risk for sepsis mortality associated with TNF-308GA. These discrepancies between studies from countries distributed over a wide geographical area might reflect differences related to the ethnic makeup of the populations, as suggested in a recent meta-analysis [6].…”

Section: Discussionsupporting

confidence: 85%

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

et al. 2012

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Section: Discussionsupporting

confidence: 85%

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

et al. 2012

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“…Cytokine levels tend to vary considerably. Patients with similar insults can exhibit inter-individual variations, which, at least in part, can be genetically determined3536.…”

Section: Discussionmentioning

confidence: 99%

Cytokine profile in severe gram-positive and gram-negative abdominal sepsis

Šurbatović

Popović

Vojvodić

et al. 2015

Sci Rep

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105

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Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive and Gram-negative bacteraemia (GPB and GNB, respectively) and to assess the prognostic value regarding outcome in critically ill patients with severe abdominal sepsis. The outcome measure was hospital mortality. Blood samples were obtained from 165 adult patients with confirmed severe abdominal sepsis. Levels of the proinflammatory mediators TNF-α, IL-8, IL-12 and IFN-γ and the anti-inflammatory mediators IL-1ra, IL-4, IL-10 and TGF-β1 were determined and correlated with the nature of the bacteria isolated from the blood culture and outcome. The cytokine profile in our study indicated that the TNF-α levels were 2-fold, IL-8 were 3.3-fold, IFN-γ were 13-fold, IL-1ra were 1.05-fold, IL-4 were 1.4-fold and IL-10 were 1.83-fold higher in the GNB group compared with the GPB group. The TNF-α levels were 4.7-fold, IL-8 were 4.6-fold, IL-1ra were 1.5-fold and IL-10 were 3.3-fold higher in the non-survivors compared with the survivors.

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“…IL-1RA, a interleukin 1-receptor antagonist, is a 17 kDa protein of the IL-1 family, which inhibits the pro-inflammatory action of IL-1α and IL-1β in order to maintain the equilibrium of the inflammatory response [26][27]. In humans, under physiological conditions, it is detected in synovial fluid, tears, blood, and cerebrospinal fluid [27].…”

Section: Interleukin-4 (Il-4) Mast Cells T Cells and Stomatal Cellsmentioning

confidence: 99%

“…Studies comparing the IL-10 genotypes AA, AG, and GG -of severely ill patients -having sepsis as the principal causeshowed that there was a statistically significant association of the G allele to higher lethality rates [26]. Upon analysis of the influence of lipopolysaccharide (LPS) desensibilization on IL-10 production, it was noticed that this process causes a reduction in the production of this cytokine.…”

Section: Anti-inflammatory Cytokines In the Context Of Sepsismentioning

confidence: 99%

Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation

AP¹,

DLS²,

PSB³

et al. 2016

J Pharma Care Health Sys

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The pathophysiology, diagnosis, treatment and prognosis of sepsis remain major challenges for contemporary clinical practice. In this sense, efforts to broaden the knowledge about the mechanisms involved in systemic inflammation and to identify new methods for detecting sepsis in the early stages and the stratification of patients are extremely important. The purpose of this paper is to review the role of the anti-inflammatory cytokines in sepsis and present perspectives on the in silico investigation of the role of these mediators in this nosological entity, using the computational system AutoSimmune.

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Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients

Cited by 28 publications

References 34 publications

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients

Cytokine profile in severe gram-positive and gram-negative abdominal sepsis

Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation

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