Polymorphisms of long non-coding RNA HOTAIR with breast cancer susceptibility and clinical outcomes for a southeast Chinese Han population

Lin, Yuxiang; Guo, Wenhui; Li, Neng; Fu, Fangmeng; Lin, Songping

doi:10.18632/oncotarget.23343

Cited by 34 publications

(40 citation statements)

References 53 publications

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“…In breast cancer, it works as a predictive marker for metastatic progression and overall survival in early‐stage surgically resected tumors . Of note, emerging studies on the susceptibility of breast cancer have indicated the genetic polymorphisms of HOTAIR . HOTAIR acts as a scaffold in a chromatin‐repressive mechanism.…”

Section: Tumor Driversmentioning

confidence: 99%

Emerging roles of long non‐coding RNA in cancer

Calle¹,

Kawamura

Yamamoto³

et al. 2018

Cancer Science

529

407

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Since comprehensive analysis of the mammalian genome revealed that the majority of genomic products are transcribed in long non‐coding RNA (lncRNA), increasing attention has been paid to these transcripts. The applied next‐generation sequencing technologies have provided accumulating evidence of dysregulated lncRNA in cancer. The implication of this finding can be seen in many forms and at multiple levels. With impacts ranging from integrating chromatin remodeling complexes to regulating transcription and post‐transcriptional processes, aberrant expression of lncRNA may have repercussions in cell proliferation, tumor progression or metastasis. lncRNA may act as enhancers, scaffolds or decoys by physically interacting with other RNA species or proteins, resulting in a direct impact on cell signaling cascades. Even though their functional classification is well‐established in the context of cancer, clearer characterization in terms of their phenotypic outputs is needed to optimize and identify suitable candidates that enable the development of new therapeutic strategies and the design of novel diagnostic approaches. The present article aims to outline different cancer‐associated lncRNA according to their contribution to tumor suppression or tumor promotion based on their most current functional annotations.

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Section: Tumor Driversmentioning

confidence: 99%

Emerging roles of long non‐coding RNA in cancer

Calle¹,

Kawamura

Yamamoto³

et al. 2018

Cancer Science

529

407

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“…Five studies [14][15][16]18,20 Figure S4; Figure 4). A subgroup analysis based on the genotyping method and ethnicity are shown in the Supporting Information Figures S5 and S6.…”

Section: Hotair Polymorphism Rs1899663 and Bc CC And Ocmentioning

confidence: 99%

The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single‐nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta‐analysis

Liu

Tang

et al. 2018

J of Cellular Biochemistry

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Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women’s health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence of it is increasing. We performed a meta‐analysis to clarify the relationship between lncRNA HOTAIR expression and BC, CC, and OC susceptibility. We thoroughly searched PubMed, Embase, and the Cochrane Library to obtain the relevant literature. We extracted data from case groups and control groups for each single‐nucleotide polymorphism (SNP) (rs4759314, rs920778, rs189663, rs12826786, rs7958904, and rs874945) and compared the relationship between alleles, codominance models, dominant and invisible models and BC, CC, and OC susceptibility. Our study included 11 studies with a total of 5322 patients. There was a significant association between the rs4759314 polymorphism of HOTAIR and susceptibility to BC, CC, and OC (codominant model: AG/AA odds ratio [OR] = 1.13 [95% confidence intervals [CI], 1.00‐1.29], GG/AA OR = 1.54 [95% CI, 1.06‐2.23]; dominant model: GG + AG/AA OR = 1.16 [95% CI, 1.02‐1.32]; and recessive model: GG/AA + AG OR = 1.51 [95% CI, 1.05‐2.19]). The association between the expression of rs920778 and BC, CC, and OC susceptibility was not clear (alleles T/C: OR = 1.28 [95% CI, 0.87‐1.89]; in codominant model: CT/CC OR = 1.10, [95% CI, 0.71‐1.71], TT/CC OR = 1.29 [95% CI, 0.59‐2.80]; dominant model: TC + TT/CC OR = 1.16, [95% CI, 0.73‐1.86]; and recessive model: TT/TC + CC OR = 1.43, [95% CI, 0.83‐2.47]). HOTAIR polymorphism rs1899663 was associated with BC, CC, and OC susceptibility to a certain extent, (alleles T/G OR = 0.90 [95% CI, 0.69‐1.16]; in the codominant model: GT/GG OR = 0.81 [95% CI, 0.50‐1.30], TT/GG OR = 1.04 [95% CI, 0.63‐1.72]; dominant model: GT + TT/GG OR = 0.82 [95% CI, 0.52‐1.29]; and recessive model: TT/GT + GG OR = 1.21 [95% CI, 0.76‐1.94]). The rs12826786, rs7958904, and rs874945 polymorphisms were associated with a certain degree of BC, CC, and OC susceptibility, but they were not statistically significant. HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent. SNPs rs12826786, rs7958904, and rs874945 did not correlate with an effect on patient susceptibility to BC, CC, and OC.

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“…SNPs within the lncRNA H19 have been found to have an increased risk of hepatocellular [61] and gastric cancer [72]. The lncRNA HOTAIR (HOX Transcript Antisense Intergenic RNA) has multiple SNPs associated with an increased risk of several cancer types [69,70,74,75]. These SNPs may affect the expression of the lncRNA or affect its secondary structure [67,73] which alters its canonical function in the cell [76].…”

Section: Lncrnas and Hiv-1 Susceptibilitymentioning

confidence: 99%