Polymorphisms on IFNG , IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population

Carvalho, Filomena Marino; Busser, Felipe Delatorre; Freitas, Vera Lúcia Teixeira de; Furucho, Célia Regina; Sadahiro, Aya; Kono, Adriana; Criado, Paulo Ricardo; Moretti, Maria Luíza; Sato, Paula Keiko; Shikanai-Yasuda, Maria Aparecida

doi:10.1016/j.meegid.2016.05.025

Cited by 15 publications

(16 citation statements)

References 71 publications

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“…The factors that determine the different outcomes of the PCM host-parasite interaction remain unknown. Preliminary data suggest that the host's immunogenetic background may play a role 30 . Regardless, clinical experiences have indicated that treatment of PCM should persist for long periods until effective cellular immune responses are elicited.…”

mentioning

confidence: 99%

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Shikanai-Yasuda

Mendes

Colombo

et al. 2017

Rev. Soc. Bras. Med. Trop.

329

590

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Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis (P. brasiliensis) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii (P. lutzii), has been reported in Rondônia, where the disease has reached epidemic levels, and in the Central West and Pará. Accurate diagnoses and availability of antigens that are reactive with the patients' sera remain significant challenges. Therefore, the present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. This consensus summarizes etiological, ecoepidemiological, molecular epidemiological, and immunopathological data, with emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression. The consensus also includes discussion of outpatient treatments, severe disease forms, disease prevalence among special populations and resource-poor settings, a brief review of prevention and control measures, current challenges and recommendations.

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mentioning

confidence: 99%

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Shikanai-Yasuda

Mendes

Colombo

et al. 2017

Rev. Soc. Bras. Med. Trop.

329

590

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“…Thus, genes related to this pathway are candidates to association with susceptibility for PCM. Variants at IFNG and IL12B genes were not associated with clinical forms of PCM in Brazilian patients, while IL12RB1 presented one polymorphism associated with the disseminated chronic form [ 93 ]. However, more variants at these genes should be tested in order to elucidate its participation in determining the clinical form.…”

Section: Genetic Aspectsmentioning

confidence: 99%

Paracoccidioidomycosis: Current Perspectives from Brazil

et al. 2017

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Background:This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.Objectives:Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings.Methods:Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.Results:Clinical forms have been better classified in order to include the pictures less frequently observesiod.Conclusion:Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.

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“…Estudos preliminares sugerem a eventual participação do background imunogenético. 30 Entretanto, o conhecimento das alterações da resposta imune que resultam da infecção é de relevância clínica para se compreender a necessidade de tratamento prolongado, até o estabelecimento de resposta imune celular eficiente. Células leveduriformes quiescentes podem persistir no interior de granulomas, por razões ainda não completamente estabelecidas, levando a recidivas da doença.…”

Section: Imunopatogeniaunclassified

II Consenso Brasileiro em Paracoccidioidomicose - 2017*

Shikanai-Yasuda¹,

Mendes²,

Colombo³

et al. 2018

Epidemiologia e Serviços de Saúde

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Paracoccidioidomycosis is a systemic fungal disease associated with agricultural activities. Its incidence and prevalence are underestimated because of the lack of reporting in several Brazilian states. If paracoccidiodomycosis is not diagnosed and treated early and adequately, endemic fungal infection may result in serious sequelae. In addition to the Paracoccidioides brasiliensis (P. brasiliensis) complex, the appearance of a new species, Paracoccidioides lutzii (P. lutzii), in Rondônia state, where the disease has reached epidemic levels, and in the country's Midwest region and Pará state, are challenges to diagnosis and to the urgent availability of antigens that are reactive with patients' sera. These guidelines aim to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. The guidelines provide data on etiology, epidemiology, immunopathogenesis, diagnosis, treatment and sequelae, with emphasis on diagnosis and treatment, as well as current recommendations and challenges in this field of knowledge.

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Polymorphisms on IFNG , IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population

Cited by 15 publications

References 71 publications

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Paracoccidioidomycosis: Current Perspectives from Brazil

II Consenso Brasileiro em Paracoccidioidomicose - 2017*

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