Polymorphismus des „brain derived neurotrophic factor“ und Erholung nach Schlaganfall

Liepert, Joachim; Heller, Andreas; Behnisch, Gusalija; Schoenfeld, Mircea Ariel

doi:10.1007/s00115-015-4325-6

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Compared with the SHA group, the two branched chain amino acids (BCAAs) leucine and isoleucine in the MOD group are greatly reduced, which may be caused by the consumption of citric acid to reactivate brain function or used as cell signaling molecules as an important energy source of citrate cycle ( Wang et al, 2017 ). Valine promotes normal growth of the body, repairs tissues, regulates blood sugar, and provides needed energy together with isoleucine and leucine ( Liepert et al, 2015 ). Arginine is a biosynthetic substrate of nitric oxide (NO).…”

Section: Discussionmentioning

confidence: 99%

An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid

Yang

Lei²,

Bao

et al. 2022

Front. Mol. Biosci.

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Folic acid has a protective effect against ischemic stroke. However, the protective pharmacological mechanism remains unclear. The aim of this study is to explore the protective effect of folic acid on ischemic stroke animals by an integrated metabolomic biomarker screening platform. Based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC/MS) coupled with multivariate data analysis, the changes in metabolites and pathways were characterized. We found that the metabolic alteration involved a total of 37 metabolites, of which 26 biomarkers such as γ-aminobutyric acid, lysine, glutamate, ribose, and valine can be regulated by folic acid via metabolic pathways of amino acid metabolism, carbohydrate metabolism, fatty acid metabolism, citrate cycle, and pyruvate metabolism, which may be the potential therapeutic targets of folic acid against ischemic stroke. Folic acid as an emerging potential natural anti-fibrosis agent has significant activity in protecting against middle cerebral artery occlusion-induced rat ischemic stroke model by delaying pathological development, reversing the metabolic biomarkers, and mainly regulating the perturbation in amino acid metabolism, carbohydrate metabolism, fatty acid metabolism, citrate cycle, and pyruvate metabolism. It also showed that the integrated metabolic biomarker screening platform could provide a better understanding of the therapeutic effect and mechanism of drugs.

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Section: Discussionmentioning

confidence: 99%

An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid

Yang

Lei²,

Bao

et al. 2022

Front. Mol. Biosci.

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Prediction of Recovery and Outcome Using Motor Evoked Potentials and Brain Derived Neurotrophic Factor in Subacute Stroke

Bembenek

Kurczych

Kłysz

et al. 2020

Journal of Stroke and Cerebrovascular Diseases

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The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients

Kotlęga

Peda

Zembroń-Łacny

et al. 2017

Neurologia i Neurochirurgia Polska

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Stroke is the main cause of motoric and neuropsychological disability in adults. Recent advances in research into the role of the brain-derived neurotrophic factor in neuroplasticity, neuroprotection and neurogenesis might provide important information for the development of new poststroke-rehabilitation strategies. It plays a role as a mediator in motor learning and rehabilitation after stroke. Concentrations of BDNF are lower in acute ischemic-stroke patients compared to controls. Lower levels of BDNF are correlated with an increased risk of stroke, worse functional outcomes and higher mortality. BDNF signalling is dependent on the genetic variation which could affect an individual's response to recovery after stroke. Several single nucleotide polymorphisms of the BDNF gene have been studied with regard to stroke patients, but most papers analyse the rs6265 which results in a change from valine to methionine in the precursor protein. Subsequently a reduction in BDNF activity is observed. There are studies indicating the role of this polymorphism in brain plasticity, functional and morphological changes in the brain. It may affect the risk of ischemic stroke, post-stroke outcomes and the efficacy of the rehabilitation process within physical exercise and transcranial magnetic stimulation. There is a consistent trend of Met alleles' being connected with worse outcomes and prognoses after stroke. However, there is no satisfactory data confirming the importance of Met allele in stroke epidemiology and the post-stroke rehabilitation process. We present the current data on the role of BDNF and polymorphisms of the BDNF gene in stroke patients, concentrating on human studies.

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Polymorphismus des „brain derived neurotrophic factor“ und Erholung nach Schlaganfall

Abstract: After ischemic stroke, motor functions and everyday activities improved continuously over a period of at least 6 months. The BDNF polymorphism did not influence this development.

Cited by 4 publications

References 21 publications

An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid

An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid

Prediction of Recovery and Outcome Using Motor Evoked Potentials and Brain Derived Neurotrophic Factor in Subacute Stroke

The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients

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