Polymorphonuclear leukocyte elastase levels in patients with Behçet's disease

Örem, Asım; Akyol, Nurettin; Bahadır, Sevgi; Yıldırmış, Sermet

doi:10.1016/0009-8981(95)06033-a

Cited by 22 publications

(14 citation statements)

References 7 publications

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“…The predominant histopathology is vasculitis with vessel walls and perivascular tissue infiltrated mainly by lymphocytes but also by monocytes, plasma cells and neutrophils [1]. It has also been shown that various functions of polymorphonuclear cells in peripheral blood such as chemotaxis, phagocytosis, superoxide radical anion (O – 2 ) generation and lysosomal enzyme activity are increased in Behçet’s disease [2, 3]. Decreased enzyme activity in the antioxidant system and increased levels of free radicals may play a role in tissue damage [4, 5, 6].…”

Section: Introductionmentioning

confidence: 99%

Autoantibodies against Oxidatively Modified Low-Density Lipoprotein in Patients with Behçet’s Disease

Örem

Çimşit²,

Değer³

et al. 1999

Dermatology

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Background: Change of lipids and lipoprotein metabolism and an imbalance of the oxidant-antioxidant system related to the disease activity have been reported in Behçet’s disease. Therefore, there is a tendency of oxidative modification of lipids and lipoproteins in patients with the disease. Objective: To investigate serum autoantibodies against oxidatively modified low-density lipoprotein (oxLDL) as a marker for the degree of in vivo oxidation of lipoproteins in Behçet’s disease. Methods: Serum autoantibodies against oxLDL, total cholesterol, triacylglycerol, HDL cholesterol, LDL cholesterol, apolipoprotein (Apo) AI, Apo B, α₁-antitrypsin, α₂-macroglobulin and erythrocyte sedimentation rate were determined in 37 patients and 30 sex- and age-matched healthy volunteers. Autoantibodies against oxLDL were measured by a commercial enzyme-linked immunosorbent assay. Results: Serum autoantibody levels against oxLDL were significantly higher in patients than in controls (425 ± 365 and 187 ± 132 mU/ml, respectively; p < 0.05). The levels of autoantibodies against oxLDL in the patients were found to correlate with total cholesterol, LDL cholesterol, HDL cholesterol and α₁-antitrypsin levels (r = 0.38, p < 0.05; r = 0.42, p < 0.05; r = –0.38, p < 0.05; r = 0.42, p < 0.05, respectively). Conclusion: It has been shown in previous studies that high autoantibody titers against oxLDL may be important in diseases with atherosclerosis as seen in systemic lupus erythematosus and rheumatoid arthritis. High autoantibody titers against oxLDL are not specific for Behçet’s disease but probably important for pathologic processes in the disease. We suggest that increased levels of autoantibodies against oxLDL may be a factor responsible for endothelial dysfunction and development of vascular pathology in Behçet’s disease.

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Section: Introductionmentioning

confidence: 99%

Autoantibodies against Oxidatively Modified Low-Density Lipoprotein in Patients with Behçet’s Disease

Örem

Çimşit²,

Değer³

et al. 1999

Dermatology

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“…In this respect, our previous study showed that PMN elastase may be a good biochemical marker for diagnosis and therapy control in patients with Behçet's disease. 27 In our next study, it was tried to describe relationships between pathogenesis and severity of BD and biochemical markers representing oxidant stress and inflammatory condition. 9 Isik et al 28 reported that OSI value was significantly higher in patient with BD as it was shown in present study.…”

Section: Discussionmentioning

confidence: 99%

Ischemia modified albumin: a useful marker for increased oxidative stress in Behçet’s disease

Keskin

Arıca

Örem

et al. 2019

Mucosa

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Background Increased oxidant stress play an important role in pathogenesis of Behçet's disease (BD). It needs to be clearly defined by using a sensitive marker. Objective We sought to investigate usefulness of ischemia modified albumin (IMA) to show increased oxidative stress in patients with BD and its value considering the disease activity. Methods The sera from BD patients (n=57) and healthy individuals (n=45) were collected. IMA, serum total antioxidative capacity (TAC) and total oxidant status (TOS) were measured using Erel's automated method, and the percentage ratio of total peroksit level to TAC level was considered the oxidative stress index (OSI). Receiver operating characteristic (ROC) curves were constructed for all markers. Results IMA, TAC, TOS, OSI, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were found to be significantly higher in patients with BD than those in controls. IMA was the only marker which showed difference between active and inactive periods, and it had higher area under curve (AUC) value than those for other markers in ROC analysis (p=0.004). IMA also showed significant correlations with CRP, both in all BD patients and those in active period (r=0.50, p<0.01; r =0.54, p<0.005, respectively). Conclusions IMA showed superiority to other markers such as TAC, TOS or OSI to evaluate oxidative stress in BD patients as well as in considering disease activity. The higher serum level of IMA and its relationship with CRP observed in active period of BD indicate that IMA may be a useful marker for monitoring disease activity.

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“…16) Therefore, it may be important to investigate the mechanism controlling the increase of PMN-elastase activity in neutrophils of patients with Behçet's disease in order to understand the pathological features of the disease. Vol.…”

Section: Digestion Of Substrate Peptide With the Cytosolic Fraction Omentioning

confidence: 99%

Characterization of a Protease Responsible for Truncated Actin Increase in Neutrophils of Patients with Behcet's Disease.

Yamashita

Suzuki

Yanagita

et al. 2001

Biological & Pharmaceutical Bulletin

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Polymorphonuclear leukocyte elastase levels in patients with Behçet's disease

Cited by 22 publications

References 7 publications

Autoantibodies against Oxidatively Modified Low-Density Lipoprotein in Patients with Behçet’s Disease

Autoantibodies against Oxidatively Modified Low-Density Lipoprotein in Patients with Behçet’s Disease

Ischemia modified albumin: a useful marker for increased oxidative stress in Behçet’s disease

Characterization of a Protease Responsible for Truncated Actin Increase in Neutrophils of Patients with Behcet's Disease.

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