Polymorphous low‐grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (α2β1 and α3β1)

Abstract

Collagen IV and laminin, and their integrin ligands, are useful in demonstrating that neoplastic ductal units of PLGA are composed of a single cell layer, being distinct from ACC which contains structures composed of two layers of neoplastic cells.

SIKVAV, a Laminin α1-Derived Peptide, Interacts with Integrins and Increases Protease Activity of a Human Salivary Gland Adenoid Cystic Carcinoma Cell Line through the ERK 1/2 Signaling Pathway

“…We have already shown that integrins influence CAC2 cell interactions with laminin. Inhibiting the function of ␣3␤1 integrin, a receptor expressed in adenoid cystic carcinoma in vivo, 3 decreased the attachment of CAC2 cells to laminin.…”

“…2 Growth patterns are solid, tubular, and pseudocystic, and perineural invasion is a common histological finding. [1][2][3] Electron microscopy shows both luminal and myoepithelial cells, and these cells are often separated by extracellular matrix (ECM), such as pools of basal lamina, collagen fibers, elastin, and glycosaminoglycans. 2 A conspicuous finding in the cribriform variant of adenoid cystic carcinoma is a thickened band of extensively duplicated basement membrane.…”

“…2 A prominent feature of adenoid cystic carcinoma is its affinity for basement membrane-rich tissues, such as nerves and blood vessels, 2 and many immunohistochemical studies have highlighted the presence of basement membrane proteins in this neoplasm. [3][4][5][6] It has been suggested that the ECM plays an important role as a regulatory factor of phenotypic differences among salivary gland neoplasms. [7][8][9][10][11][12][13][14] The ECM is a three-dimensional network of macromolecules, including collagens, laminins, fibronectin, entactin/nidogen, and heparan sulfate proteoglycans.…”

Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40− Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma

“…However, while many immunohistochemical stains (e.g., c-kit, Ki-67, glial fibrillary acidic protein, CD43, S100, bcl-2, etc.) have been used to aid in this differential diagnosis, none of them distinguishes these tumors in a consistently reliable manner [9][10][11][12][13][14][15][16][17][18][19][20].…”

Extracellular material in adenoid cystic carcinoma of the salivary glands: A comparative cytological study with other salivary myoepithelial tumors

“…1 On the other hand, extracellular materials (ECMs) including type IV collagen, laminin heparan sulfate proteoglican, and entactin have been found in immunohistochemistory and in electron microscopy in AdCC. [2][3][4][5][6] In cytology, the ECM shows various shapes and to date there is no consensus opinion on the ECM shapes and AdCC patterns. [7][8][9] In this study, we examined both the imprint and fineneedle aspiration cytological smears of seven tumors histologically diagnosed as AdCC, focusing on morphological characteristic of the ECM.…”