Polymyalgia Rheumatica and Temporal Arteritis in a Married Couple

Garfinkel, Doron; Bograd, H; Salamon, F.; Aderka, Dan; Shoenfeld, Yehuda; Weinberger, Abraham; Pinkhas, J

doi:10.1097/00000441-198405000-00017

Cited by 14 publications

(6 citation statements)

References 16 publications

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“…Even if the occurrence of PMR affecting both members of an unrelated and cohabitating married couple is rare, previous cases have been described in the literature [4][5][6][7][8][9][10][11]. The almost simultaneous onset of these cases supports the hypothesis that common exposure to an unknown environmental risk factor could be partially responsible for the development of the disease.…”

Section: Introductionmentioning

confidence: 85%

An Unusual Case of “Conjugal” Polymyalgia Rheumatica after SARS-CoV-2 Vaccination

et al. 2021

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The rare occurrence of polymyalgia rheumatica (PMR) in married couples has been reported in the literature. Susceptibility to PMR is contributed by genetic and environmental factors and cases of PMR developing after influenza vaccine have also been described, in a debated phenomenon known as ‘ASIA’ syndrome. We report the case of two cohabitating married patients developing PMR few weeks after the first dose of ChAdOx1-S SARS-CoV-2 vaccine. Both patients presented with typical symptoms suggestive of PMR. Laboratory findings and ultrasound examination confirmed the diagnosis. Glucocorticoid therapy led to rapid improvment of symptoms. Anti-receptor-binding domain IgG titre was tested and, eight weeks after vaccination, both patients showed no antibody response. It has been suggested that vaccines might trigger autoimmune or inflammatory states in predisposed individuals and various hypotheses have been made regarding the pathogenesis of PMR. Although the causative effect of vaccines cannot be determined, the close temporal correlation observed in our case supports the potential role of environmental factors in triggering the onset of PMR. However, the literature indicates that post-COVID19 vaccination immune-mediated or inflammatory adverse events are extremely rare and vaccination should be encouraged since the benefit largely outweighs possible risks.

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Section: Introductionmentioning

confidence: 85%

An Unusual Case of “Conjugal” Polymyalgia Rheumatica after SARS-CoV-2 Vaccination

et al. 2021

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“…During the last 20 years, no case of PMR in a married couple occurred, or it was not published. Although in most of these cases, a genetic disposition5,8,9 and an infectious agent6,7,9 have been discussed, it is difficult to build up this hypothesis on a few case reports. Moss and Soukop concluded that “a powerful argument against an infective etiology remains the long time interval which may separate the onset of symptoms in family members or conjugal pairs.”15 In the present couple, we have no data from the family history of the husband since he grew up in a children’s home and was placed with foster parents later.…”

Section: Discussionmentioning

confidence: 99%

Polymyalgia rheumatica in a married couple

Rüst¹,

Knechtle²,

Rosemann³

et al. 2012

IJGM

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The case of a married couple developing polymyalgia rheumatica (PMR) consecutively is presented. The 55-year-old wife complained in June 2010 about pain in her neck. Case history, physical examination, and erythrocyte sedimentation rate (ESR) of 80 mm/hour led to the diagnosis of PMR. In May 2011, her 66-year old husband complained about pain in his neck, shoulders, buttocks, and thighs. Considering anamnesis, physical examination, and ESR of 56 mm/hour, the diagnosis of PMR was made. Both wife and husband responded to steroid treatment. When the steroid dose was gradually reduced, both patients relapsed. In order to lower the cumulative dose of glucocorticoid therapy, 10 mg methotrexate per week was added. In the literature, six cases of polymyalgia rheumatica in married couples have been described to date. In four cases, polymyalgia rheumatica occurred first in the wife. The interval of the diagnosis between the spouses ranged from 0 to 89 months. Although in most of the previous case reports a genetic disposition and an infectious agent have been discussed, this hypothesis must be questioned.

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“…On peut supposer dans notre observation qu'un facteur environnemental Les cas rapportés d'association entre un lupus érythéma-teux systémique (LES) et une sarcoïdose sont assez rares. En effet, jusqu'à présent, moins de 20 cas d'une telle association chez un même patient ont été publiés dans la littérature de langue anglaise [1][2][3][4][5][6]. Récemment, Begum et al [7], ont décrit l'association d'un LES et d'une sarcoïdose chez trois patients au sein d'une cohorte de 300 patients atteints de LES et suivis dans leur Centre.…”

Section: Observationsunclassified

“…Ces trois cas indiquent, au sein de cette population lupique, une prévalence de la sarcoïdose de 1 %, une valeur bien supérieure à celle observée dans la population générale. Il a été suggéré qu'une telle association ne soit pas le fait du hasard, mais témoigne de mécanismes physiopathogéniques communs [1,3]. Nous avons eu à prendre en charge récemment une patiente atteinte d'une sarcoï-dose pulmonaire ancienne, qui a développé des signes de LES.…”

Section: Observationsunclassified