Polymyalgia rheumatica: crafting the future of a simple (but not easy!) clinical syndrome

Bond, Milena; Dejaco, Christian

doi:10.1136/ard-2023-225192

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Moreover, clinical predictive factors of the presence of large vessel vasculitis, in patients with apparently isolated PMR, are lacking, 21 as is evidence whether such patients require more aggressive treatment. 22 In the context of this recommendation, then, should the GP also be responsible for screening large vessel involvement in patients with PMR? Some cancers may elicit or mimic PMR symptoms.…”

Section: Referral Of Patients With Suspected Polymyalgia Rheumatica: ...mentioning

confidence: 99%

Referral of patients with suspected polymyalgia rheumatica: how complete is our view of ‘planet PMR?’

Camellino,

Matteson

2024

Ann Rheum Dis

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Section: Referral Of Patients With Suspected Polymyalgia Rheumatica: ...mentioning

confidence: 99%

Referral of patients with suspected polymyalgia rheumatica: how complete is our view of ‘planet PMR?’

Camellino,

Matteson

2024

Ann Rheum Dis

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Investigational agents for polymyalgia rheumatica treatment: assessing the critical needs for future development

Iorio,

Padoan,

Bond

et al. 2024

Expert Opinion on Investigational Drugs

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Subclinical aortic inflammation in patients with polymyalgia rheumatica

Kaymakci,

Berry,

Langenfeld

et al. 2024

Rheumatology

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Objectives To examine the clinicopathologic features of patients with polymyalgia rheumatica (PMR) who had thoracic aorta repair surgery. Findings were compared with those of a cohort of patients with giant cell arteritis (GCA) requiring thoracic aorta repair. Methods All patients evaluated at Mayo Clinic in Rochester, MN, with Current Procedural Terminology (CPT) codes for thoracic aorta repair surgery between 2000– 2021 were identified. All patients were screened for prior PMR diagnosis. Patients with PMR and no signs of GCA were categorized as clinically isolated PMR. The medical records of all patients were manually reviewed, and pathologists re-examined all the aortic tissues. Results Of the 4621 patients with at least one CPT code for thoracic aorta repair surgery, 43 patients were diagnosed with clinically isolated PMR before the surgery. Detailed histopathological examination of the aortic tissues revealed active inflammation in 30/43 (70%) patients after a median (IQR) of 10.0 (4.7– 13.3) years from the PMR diagnosis. When compared with aortic tissue from patients with a prior diagnosis of GCA, the aorta of patients with PMR had more severe inflammation (Grade 3: 15/30 [50%] vs 5/34 [15%], p= 0.002). Patients with PMR and thoracic aorta repair may experience a 40% increased risk of mortality compared with the general population, but this did not reach statistical significance (standardized mortality ratio: 1.40; 95% CI: 0.91– 2.07). Conclusions Some patients with PMR have subclinical aortic inflammation that is detectable many years after initial diagnosis and may contribute to the development of aortic aneurysm.

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Polymyalgia rheumatica: crafting the future of a simple (but not easy!) clinical syndrome

Cited by 4 publications

References 24 publications

Referral of patients with suspected polymyalgia rheumatica: how complete is our view of ‘planet PMR?’

Referral of patients with suspected polymyalgia rheumatica: how complete is our view of ‘planet PMR?’

Investigational agents for polymyalgia rheumatica treatment: assessing the critical needs for future development

Subclinical aortic inflammation in patients with polymyalgia rheumatica

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