Polyovular follicles and multinucleate ova in the ovaries of young rats

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the female reproductive tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. There is also a section on normal cyclical changes observed in the ovary, uterus, cervix and vagina to compare normal physiological changes with pathological lesions. A widely accepted and utilized international harmonization of nomenclature for female reproductive tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“… 21 Chen et al (2007), 95 Kent (1960), 96 Kent (1962), 98 Kim et al (2009), 191 Telfer and Gosden (1987)…”

Section: Morphologymentioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Alison²,

et al. 2014

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“…Bacsich (3) suggested, that their presence in early life may be linked to the withdrawal of maternal gonadotrophin hormones or estrogens at the time of birth. Polynuclear oocytes have often been described in the ovaries of immature animals of many species (10,13,16,17,18,19). Administration of estrogen reduced the number of polynuclear oocytes normally seen in the hamster ovary (17).…”

Section: Discussionmentioning

confidence: 99%

Follicular Development in Ovaries of Children With Down's Syndrome

Højager¹,

Peters²,

Byskov³

et al. 1978

Acta Paediatrica

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Ovaries of children with Down's syndrome were examined histologically in order to determine in what way the ovarian development differed from the normal. Twenty-six specimens obtained at autopsy at various ages between birth and 14 1/2 years were available and compared with ovaries from normal children of similar ages. All ovaries from normal children were characterized by active follicle growth. The ovaries of the children with Down's syndrome, however, showed absence or retardation of follicle growth. Furthermore the number as well as the size of the antral follicles differed from those in the normal ovary. The decrease of the number of small follicles occurs earlier in life in the ovaries of children with Down's syndrome than in the control. The possible relationship between an abnormal ovarian growth pattern and hormonal imbalance is discussed.

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“…The occurrence of follicles with a single oocyte is classically described for mammals, but many authors have reported follicles with two or more oocytes delimited by a membrane in a single follicle (LUCCI et al, 2002;REYNAUD et al, 2009;. These follicles have been described using different names: multi-oocyte follicles, polyovocytaires follicles (REYNAUD et al, 2009(REYNAUD et al, , 2010, multinucleated eggs (KENT JR, 1962) and polyovular follicles (KENNEDY, 1924;ALM et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Proliferative activity of oocytes in multi-oocyte follicles of bovine ovary

Oliveira

Silva-Santos

Gonzalez

et al. 2017

SCA

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We characterized the proliferative activity of multi-oocyte follicles with anti-nuclear antigen of proliferating cells (PCNA). Ovaries (n = 12) from heifers were processed for histology. From 789 multi-oocytes follicles observed, only 11 were considered appropriated for immunostaining, since they presented all nuclei of the oocytes clearly visible. All multi-oocyte follicles were positive for PCNA, but some oocytes showed no proliferative activity. We conclude that oocytes in multi-oocyte follicles seem to be in different stages of the cell cycle.

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Polyovular follicles and multinucleate ova in the ovaries of young rats

Cited by 11 publications

References 8 publications

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Follicular Development in Ovaries of Children With Down's Syndrome

Proliferative activity of oocytes in multi-oocyte follicles of bovine ovary

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