Polyoxygenated cembrane-type diterpenes from the Hainan soft coral Lobophytum crassum as a promising source of anticancer agents with ErbB3 and ROR1 inhibitory potential

Shen, Shou-mao; Yu, Dan-dan; Ke, Lin-mao; Yao, Li-gong; Su, Ming-zhi; Guo, Yue-wei

doi:10.1038/s41401-024-01347-z

Acta Pharmacol Sin

2024

DOI: 10.1038/s41401-024-01347-z

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Polyoxygenated cembrane-type diterpenes from the Hainan soft coral Lobophytum crassum as a promising source of anticancer agents with ErbB3 and ROR1 inhibitory potential

Shou-mao Shen,

Dan-dan Yu,

Lin-mao Ke

et al.

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Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

Peng,

Zeng,

Zhang

et al. 2024

Marine Drugs

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Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A–E (1–5), were isolated from the soft coral Sarcophyton crassocaule, along with five previously reported compounds (6–10). The structures and absolute configuration for new compounds 1–5 were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds 3, 4, and 9 showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.

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Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

Peng,

Zeng,

Zhang

et al. 2024

Marine Drugs

View full text Add to dashboard Cite

show abstract

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Polyoxygenated cembrane-type diterpenes from the Hainan soft coral Lobophytum crassum as a promising source of anticancer agents with ErbB3 and ROR1 inhibitory potential

Cited by 1 publication

References 49 publications

Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

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