Polyphenol Extracts From Germinated Mung Beans Can Improve Type 2 Diabetes in Mice by Regulating Intestinal Microflora and Inhibiting Inflammation

Abstract

Studies have shown that inhibiting inflammation and regulating intestinal microflora imbalance is a significant factor in controlling the development of type 2 diabetes mellitus (T2DM). This experiment studied the protective effect of polyphenol extract from germinated mung beans on diabetic C57BL/6 mice.ResultsFasting blood glucose (FBG) was decreased, glucose tolerance was increased, insulin resistance was decreased, serum lipid indexes in T2DM mice were improved, and the enzyme activities of alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were reduced. Meanwhile, the levels of interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) in serum were decreased, the concentration of interleukin 10 (IL-10) in serum was increased, inhibiting the inflammatory reaction induced by diabetes and repairing the morphology of mice liver tissue. At the same time, germinated mung bean polyphenol (GMP) can regulate the main intestinal flora, Firmicutes, Bacteroidetes, and Proteobacteria in diabetic mice and can also regulate species diversity and improve intestinal flora imbalance. Taken together, the experimental conclusion is a certain dose of polyphenol extract from germinated mung beans that can improve mouse T2DM by inhibiting inflammatory reaction and regulating intestinal microflora.

The effects of using Tempeh as a supplement for type 2 diabetes

“…In many animal and cellular models, isoflavones have effectively demonstrated their ability to activate human islet β‐cell proliferation, protect islet β‐cells, and improve insulin secretion (Duru et al, 2018 ). In type 2 diabetes mice, polyphenol extracts reduced serum alanine aminotransferase (ALT) and aspartate transaminase (AST) activities, inhibited inflammatory responses, and regulated intestinal microflora, which improved the expression of type 2 diabetes (Shen et al, 2022 ). Together, the improvement of type 2 diabetes may be related to the nutritional composition and biological activity of Tempeh.…”

“…In type 2 diabetes mice, polyphenol extracts reduced serum alanine aminotransferase (ALT) and aspartate transaminase (AST) activities, inhibited inflammatory responses, and regulated intestinal microflora, which improved the expression of type 2 diabetes (Shen et al, 2022).…”

Potential effects of Mudga (Vigna radiata L. Wilczek) as a dietetic food and medication for diabetes

“…The reason for this was because germinated Mung bean polyphenol (GMP) has the ability to control intestinal flora imbalance and regulate species diversity in diabetic mice, in addition to regulating Firmicutes, Bacteroidetes, and Proteobacteria. [16] Another research demonstrated the ability of Mung bean soup containing vitexin and isovitexin to suppress the production of advanced glycation end products and the enzymes that metabolise carbohydrates, alphaamylase and alpha-glucosidase. [17] In another study, rats given sprouted Mung beans were shown to have higher levels of both α-amylase and α-glucosidase inhibitory activity, which evaluated the potential antidiabetic properties of Mung beans.…”

Sodium butyrate attenuate hyperglycemia-induced inflammatory response and renal injury in diabetic mice

“…According to Shen's method (16), the concentrations of IL-1β in the serum of mice were detected by an ELISA kit (Meimian, Yancheng, China). The serum samples were added to the plates and incubated at 37 °C for 30 min, and then washed 3 times.…”