Polyphenol-Rich Extracts Obtained from Winemaking Waste Streams as Natural Ingredients with Cosmeceutical Potential

Matos, Melanie S.; Romero-Díez, Rut; Álvarez, Ana; Bronze, Maria Rosário; Rodríguez‐Rojo, Soraya; Mato, Rafael B.; Cocero, Marı́a José; Matias, Ana A.

doi:10.3390/antiox8090355

Cited by 52 publications

(75 citation statements)

References 55 publications

(74 reference statements)

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“…Very recently, microwave pretreatment prior to conventional solid-liquid extraction has been found to lead to overall better outcomes for the preparation of polyphenol-rich extracts from winemaking process wastes with cosmeceutical potential (114). High efficiency has been reported also for ultrasoundassisted emulsification-extraction of polyphenols from grape seeds and alperujo, using methanol/water (dispersed phase)hexane (continuous phase) emulsions formed in the presence of ultrasounds (115).…”

Section: Grape and Wine Byproductsmentioning

confidence: 99%

Bioactive Phenolic Compounds From Agri-Food Wastes: An Update on Green and Sustainable Extraction Methodologies

et al. 2020

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Phenolic compounds are broadly represented in plant kingdom, and their occurrence in easily accessible low-cost sources like wastes from agri-food processing have led in the last decade to an increase of interest in their recovery and further exploitation. Indeed, most of these compounds are endowed with beneficial properties to human health (e.g., in the prevention of cancer and cardiovascular diseases), that may be largely ascribed to their potent antioxidant and scavenging activity against reactive oxygen species generated in settings of oxidative stress and responsible for the onset of several inflammatory and degenerative diseases. Apart from their use as food supplements or as additives in functional foods, natural phenolic compounds have become increasingly attractive also from a technological point of view, due to their possible exploitation in materials science. Several extraction methodologies have been reported for the recovery of phenolic compounds from agri-food wastes mostly based on the use of organic solvents such as methanol, ethanol, or acetone. However, there is an increasing need for green and sustainable approaches leading to phenolic-rich extracts with low environmental impact. This review addresses the most promising and innovative methodologies for the recovery of functional phenolic compounds from waste materials that have appeared in the recent literature. In particular, extraction procedures based on the use of green technologies (supercritical fluid, microwaves, ultrasounds) as well as of green solvents such as deep eutectic solvents (DES) are surveyed.

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Section: Grape and Wine Byproductsmentioning

confidence: 99%

Bioactive Phenolic Compounds From Agri-Food Wastes: An Update on Green and Sustainable Extraction Methodologies

et al. 2020

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“…Skin aging might happen via two mechanisms: The first termed intrinsic or age dependent, is initiated by several factors, such as telomere shortening, free radicals and antioxidants imbalance and hormonal changes, while the second mechanism-photoaging is due to exposure of the skin to UV solar radiation [20]. Both mechanisms of aging cause inhibition of tissue regeneration, growth and differentiation and mainly occur at the level of dermal connective tissue, resulting in loss of mature collagen, elastin fibers, and hyaluronic acid [78]. Reactive oxygen species (ROS) and heavy metals trigger skin aging via destruction of the antioxidant system, leading to wrinkle formation, melanogenesis and severe damage of biomolecules, such as DNA.…”

Section: Extracts (Secondary Metabolites) Activities-gene Expression mentioning

confidence: 99%

Plant In Vitro Systems as a Sustainable Source of Active Ingredients for Cosmeceutical Application

Marchev

Georgiev

2020

Molecules

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Cosmeceuticals are hybrids between cosmetics and pharmaceuticals which are being designed for a dual purpose: (1) To provide desired esthetical effects and (2) simultaneously treat dermatological conditions. The increased demand for natural remedies and the trends to use natural and safe ingredients resulted in intensive cultivation of medicinal plants. However, in many cases the whole process of plant cultivation, complex extraction procedure, and purification of the targeted molecules are not economically feasible. Therefore, the desired production of natural cosmetic products in sustainable and controllable fashion in the last years led to the intensive utilization of plant cell culture technology. The present review aims to highlight examples of biosynthesis of active ingredients derived through plant in vitro systems with potential cosmeceutical application. The exploitation of different type of extracts used in a possible cosmeceutical formulation, as well as, their activity tested in in vitro/in vivo models is thoroughly discussed. Furthermore, opportunities to manipulate the biosynthetic pathway, hence engineering the biosynthesis of some secondary metabolites, such as anthocyanins, have been highlighted.

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“…In the last decades, the pharmaceutical industry has become aware that the bio-waste originating from grapes and apples processing can be an important source of phytochemicals to be destined to cosmetic, pharmaceutical and food industries [ 1 , 6 , 7 , 8 , 9 ]. As a consequence, bio-waste has being recently used for the production of dietary supplements, functional foods, food additives and nutraceuticals for human consumption [ 4 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Italy is among the Mediterranean countries mostly contributing to this production, with 0.7 million he of vineyards and 51 million hl of wine produced [ 16 ]. This production generates a huge amount of waste that is mainly made up of lees, skin, seeds and stalks and which management is ecologically and economically demanding [ 9 ]. This biomass, indeed, cannot be used as fertilizer because of its high content in phenolic acids that inhibits seed germination and must, thus, be burned or composted [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses

Badolati

Masselli

Maisto

et al. 2020

Foods

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Grapes and apples are the most cultivated fruits in the Mediterranean basin and their agricultural processing is responsible for the production of a large amount of bio-waste. The reuse of this food biomass would increase the volume of recyclable/renewable biomaterial and lower the environmental impact due to the increasing demand for these biological products. To this purpose, agri-food waste from grape and apple processing have become an important source of phytochemicals, and many pharmaceutical industries are using it as starting material to produce dietary supplements, functional foods, and food additives for human consumption. In virtue of the chemical diversity and complexity of agri-food biowaste, developers and producers of nutraceuticals are advised to assess the safety of their final nutraceutical products, in compliance with European Food Safety Authority regulation. Here, we use the Ames test to assess the mutagenicity of three nutraceuticals obtained from agri-food waste biomasses: Taurisolo® from grape pomace of Vitis vinifera L. cv ‘Aglianico’, AnnurComplex® from Malus pumila M. cv ‘Annurca’ and Limoncella Apple Extract from Malus domestica B. cv ‘Limoncella’. The results showed that all three nutraceuticals were non-mutagenic.

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Polyphenol-Rich Extracts Obtained from Winemaking Waste Streams as Natural Ingredients with Cosmeceutical Potential

Cited by 52 publications

References 55 publications

Bioactive Phenolic Compounds From Agri-Food Wastes: An Update on Green and Sustainable Extraction Methodologies

Bioactive Phenolic Compounds From Agri-Food Wastes: An Update on Green and Sustainable Extraction Methodologies

Plant In Vitro Systems as a Sustainable Source of Active Ingredients for Cosmeceutical Application

Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses

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