Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr–Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells

Trécul, Anne; Morceau, Franck; Gaigneaux, Anthoula; Orsini, Marion; Chateauvieux, Sébastien; Grandjenette, Cindy; Dicato, Mario; Diederich, Marc

doi:10.1016/j.canlet.2013.06.023

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…Different solvents influence the extraction efficiencies of the different phenolic components in different ways (Su et al, 2014). Trécul et al (2013) reported tri-vanillate derived with capacity for kinase phosphorylation inhibition in leukemia cells. Sinapic acid is widespread in fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants and as such is common in the human diet.…”

Section: 7mentioning

confidence: 99%

Chemical characterization and antioxidant capacity of red radish (Raphanus sativus L.) leaves and roots

Goyeneche

Roura

Ponce

et al. 2015

Journal of Functional Foods

124

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Section: 7mentioning

confidence: 99%

Chemical characterization and antioxidant capacity of red radish (Raphanus sativus L.) leaves and roots

Goyeneche

Roura

Ponce

et al. 2015

Journal of Functional Foods

124

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“…Total RNA extraction, reverse transcription, and real-time PCR All reagents used were treated with anti-RNase. The total RNA extraction and the quantification of RNA were performed as previously described [43].…”

Section: Immunoprecipitation Assaysmentioning

confidence: 99%

Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks

Trécul

Morceau

Gaigneaux

et al. 2014

Biochemical Pharmacology

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“…In tumorigenesis, activated STATs are linked to constitutive activation of tyrosine kinases, including Jak, Break point cluster–Abelson (Bcr-Abl), Epidermal growth factor receptor (EGFR), Src. Selected natural compounds were shown to interfere with JAK/STAT signaling [ 19 , 68 , 69 , 70 ] (see Figure 7 for a comprehensive overview).…”

Section: Stat Signaling In Health and Diseasementioning

confidence: 99%

Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery

2015

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Part of our ocean’s richness comes from its extensive history of supporting life, resulting in a highly diverse ecological system. To date, over 250,000 species of marine organisms have been identified, but it is speculated that the actual number of marine species exceeds one million, including several hundreds of millions of species of marine microorganisms. Past studies suggest that approximately 70% of all deep-sea microorganisms, gorgonians, and sea sponges produce secondary metabolites with anti-cancer activities. Recently, novel FDA-approved drugs derived from marine sponges have been shown to reduce metastatic breast cancer, malignant lymphoma, and Hodgkin’s disease. Despite the fact that many marine natural products have been shown to possess a good inhibition potential against most of the cancer-related cell signaling pathways, only a few marine natural products have been shown to target JAK/STAT signaling. In the present paper, we describe the JAK/STAT signaling pathways found in marine organisms, before elaborating on the recent advances in the field of STAT inhibition by marine natural products and the potential application in anti-cancer drug discovery.

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Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr–Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells

Cited by 6 publications

References 41 publications

Chemical characterization and antioxidant capacity of red radish (Raphanus sativus L.) leaves and roots

Chemical characterization and antioxidant capacity of red radish (Raphanus sativus L.) leaves and roots

Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks

Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery

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