Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice

Abstract

Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some biomarkers of aging, life span and spontaneous tumorigenesis has been studied in female SHR mice. Administration of BP-C3 with drinking water (0.005%) did not exert any toxic effect (did not have effect on general condition of animals, weight dynamics and consumption of food), postponed age-related switch-off of estrous function, caused slight reduction of body temperature. An increased survival was observed in mice treated with BP-C3 (p=0.00164, log rank test). BP-C3 increased mean lifespan – by 8.4%, lifespan of the last 10% of animals – by 12.4%, and life span of tumor-free mice – by 11.6%. A tendency in ability of BP-C3 to inhibit development of spontaneous tumors in mice was detected, though it did not reach the level of statistical significance (p=0.166, log rank test). The number of malignant mammary tumors was 1.5 times less and total number of tumors of various localizations was 1.6 times less in BP-C3 treated animals. Multiple tumors were registered in 8% of mice in the control group and no cases – in BP-C3 treated group. Thus, BP-C3 demonstrated some anti-carcinogenic and a pronounced geroprotective activity.

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

“…Investigational medicinal product, BP-C2, a composition of BP-Cx-1 with ammonium molybdate, inhibits radiation-induced skin damage in mice (13) and improves quality of life of patients with cancer treated with 5-FU-containing regimens (14). BP-C3, used in the present study, was previously demonstrated to exhibit geroprotective activity (15).…”

“…The results of previous study on BP-C2, administered from week 2-26 in combination with a FOLFIRINOX regimen in a patient with inoperable pancreatic cancer, indicated that during treatment no neutropenia developed for 18 weeks, and blood biochemistry normalised by week 25 (14). In a long-term study performed in female SHR mice, the mean life span increased by ~50 days in animals treated with BP-C3 compared with the untreated control group (15). A greater number of tumour-free mice and delayed age-related switch-off of the oestrus function were observed, possibly due to immunomodulatory effect of BP-C3 (15).…”

“…In a long-term study performed in female SHR mice, the mean life span increased by ~50 days in animals treated with BP-C3 compared with the untreated control group (15). A greater number of tumour-free mice and delayed age-related switch-off of the oestrus function were observed, possibly due to immunomodulatory effect of BP-C3 (15).…”

Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targets in silico and in vitro

“…BP-C3 is a composition of BP-Cx-1 with iron complex, selenium, ascorbic acid, and retinol. It exhibits geroprotective activity [ 19 ] and reduces 5-fluorouracil toxicity in mice by accelerating recovery of leukopoiesis and protecting small intestine epithelium [ 20 ].…”

Assessment of pharmacokinetics and biological effects of lignin-derived polyphenolic compositions BP-C3 and BP-C2 in in vivo models

“…BP-C3 is a formulation, which comprises BP-Cx-1 with iron complex, selenium, ascorbic acid and retinol. Longterm treatment with BP-C3 had anticarcinogenic and geroprotective activity in female SHR mice [2]. BP-C3 was found to reduce the toxic effect of 5-fluorouracil against hematopoiesis and intestinal epithelium which was evident by preserved organ/body ratios for the lymphopoietic organs, anemia reduction and intestinal crypt survival [3].…”