Polyphenolic-enriched peach peels extract regulates lipid metabolism and improves the gut microbiota composition in high fat diet-fed mice

Kan, Juan; Chen, Cuicui; Huo, Tongbin; Xie, Wangjin; Hui, Yaoyao; Jin, Changhai

doi:10.1016/j.jff.2020.104082

Cited by 24 publications

(16 citation statements)

References 59 publications

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“…Our current results showed that the relative abundance of Proteobacteria significantly decreased in the INU and RS group ( P < 0.05 or P = 0.06). In HFD mice, Bacteroides and Barnesiella are negatively correlated with obesity ( Kan et al., 2020 ). The abundance of Alistipes has a significant negative correlation with body weight, TC, TG, HDL-C, LDL-C, and blood glucose of mice ( Liu et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary fibers with different viscosity regulate lipid metabolism via ampk pathway: roles of gut microbiota and short-chain fatty acid

Liu¹,

Xia²,

Chen³

et al. 2022

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Dietary fibers with different viscosity regulate lipid metabolism via ampk pathway: roles of gut microbiota and short-chain fatty acid

Liu¹,

Xia²,

Chen³

et al. 2022

Poultry Science

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“…HFD-induced obesity is often associated with insulin and leptin resistance ( Paranjape et al, 2011 ; Zhang et al, 2014 ). Obesity induces lipid accumulation in multiple organs and has been studied in peripheral tissues ( Kan et al, 2020 ). Until now, the effects of obesity-related lipid accumulation in the CNS have not been fully understood.…”

Section: Discussionmentioning

confidence: 99%

Chronic high-fat diet induces overeating and impairs synaptic transmission in feeding-related brain regions

Wang

2022

Front. Mol. Neurosci.

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Obesity is linked to overeating, which can exacerbate unhealthy weight gain. However, the mechanisms for mediating such linkages are elusive. In the current study, we hypothesized that synaptic remodeling occurs in feeding-related brain regions of obese mice. To investigate this, we established a high-fat diet (HFD)-induced obese mouse model and observed that these mice consumed excessive calories. The effect of chronic HFD feeding on lipid droplet accumulation in different brain structures was also investigated. We found that lipid droplets accumulated on the ependyma of the third ventricle (3V), which is surrounded by key areas of the hypothalamus that are involved in feeding. Then, the spontaneous synaptic activity of miniature excitatory postsynaptic current (mEPSC) and miniature inhibitory postsynaptic current (mIPSC) was recorded in these hypothalamic areas. HFD induced a decreased amplitude of mEPSC in the arcuate nucleus (ARC) and the ventromedial hypothalamus (VMH), meanwhile, increased the frequency in the VMH. In addition, HFD reduced the frequency of mIPSC in the lateral hypothalamus (LH) and increased the amplitude of mIPSC in the paraventricular nucleus of the hypothalamus (PVH). Subsequently, we also measured the synaptic activity of nucleus accumbens (NAc) neurons, which play a vital role in the hedonic aspect of eating, and discovered that HFD diminished the frequency of both mEPSC and mIPSC in the NAc. These findings suggest that chronic HFD feeding leads to lipid accumulation and synaptic dysfunction in specific brain regions, which are associated with energy homeostasis and reward regulation, and these impairments may lead to the overeating of obesity.

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“…Kan et al ( 2020 ) investigated the influence of peach peel phenolic extract in preventing lipid accumulation and intestinal microbiota composition of mice with high-fat diet-induced obesity. Extracts were obtained with methanol by ultrasound technique (400 W, 40 °C) for 3 h. The recovered extracts showed that peach peel significantly inhibited lipid accumulation in mice fed with a high-fat diet.…”

Section: Bioactivities Associated To Peach By-productsmentioning

confidence: 99%

From Biorefinery to Food Product Design: Peach (Prunus persica) By-Products Deserve Attention

Monteiro

Zielinski

Ferreira

2022

Food Bioprocess Technol

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There is an increasing demand for functional foods to attend the consumers preference for products with health benefits. Peach ( Prunus persica ), from Rosaceae family, is a worldwide well-known fruit, and its processing generates large amounts of by-products, consisting of peel, stone (seed shell + seed), and pomace, which represent about 10% of the annual global production, an equivalent of 2.4 million tons. Some studies have already evaluated the bioactive compounds from peach by-products, although, the few available reviews do not consider peach by-products as valuable materials for product design methodology. Thereby, a novelty of this review is related to the use of these mostly unexplored by-products as alternative sources of valuable components, encouraging the circular bioeconomy approach by designing new food products. Besides, this review presents recent peach production data, compiles briefly the extraction methods for the recovery of lipids, proteins, phenolics, and fiber from peach by-products, and also shows in vivo study reports on anti-inflammatory, anti-obesity, and anti-cerebral ischemia activities associated with peach components and by-product. Therefore, different proposals to recover bioactive fractions from peach by-products are provided, for further studies on food-product design.

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Polyphenolic-enriched peach peels extract regulates lipid metabolism and improves the gut microbiota composition in high fat diet-fed mice

Cited by 24 publications

References 59 publications

Dietary fibers with different viscosity regulate lipid metabolism via ampk pathway: roles of gut microbiota and short-chain fatty acid

Dietary fibers with different viscosity regulate lipid metabolism via ampk pathway: roles of gut microbiota and short-chain fatty acid

Chronic high-fat diet induces overeating and impairs synaptic transmission in feeding-related brain regions

From Biorefinery to Food Product Design: Peach (Prunus persica) By-Products Deserve Attention

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