Polyphenolic-modified cellulose acetate membrane for bone regeneration through immunomodulation

Zhang, Qingyi; Tan, Jie; Huang, Kai; Nie, Rong; Feng, Zi-Yuan; Zou, Chen-Yu; Li, Qianjin; Sheng, Ning; Qin, Bo-Quan; Z, Gu; Liu, Limin; Xie, Huiqi

doi:10.1016/j.carbpol.2023.120546

Cited by 23 publications

(7 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28,29 In the CAHA, CAHAGO 1.0%, and CAHAGO 1.5% groups, distinct transmittance peaks can be observed around 927 and 961 cm −1 . These peaks are characteristic bands of P-OH stretching in HPO 4 and symmetric PO 4 3 stretching, respectively. 30,31 The absorbance band at approximately 1590 cm −1 is related to the water bending mode.…”

Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

“…Biomaterials have been developed to accelerate the healing process, in which cellulose, as well as its derivatives, have shown great potential due to their physicochemical properties, biocompatibility, and ability to promote bone regeneration. [3][4][5] Materials composed of Cellulose Acetate (CA) have demonstrated satisfactory biological activities, however there are still opportunities to improve this material offering superior properties for tissue regeneration. 6,7 Therefore, to enhance the structural and biological characteristics of these scaffolds, the combination of CA with other synthetic or natural nanocomposites has shown an increase in the mechanical, chemical, and biological properties of this biomaterial.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 To achieve positive responses in damaged tissue, improved biomaterials need to demonstrate the ability to modulate the tissue development process. 3,10 Based on this, several nanoparticle incorporation strategies have been used to enhance the mechanical and biological properties, with the objective of providing a suitable environment for tissue nourishment and regeneration. 11,12 Cellulose-based biomaterials have been increasingly utilized in a synthesis process called electrospinning, which originated in the textile industry.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

Menezes,

Navarro da Rocha,

Carajelescov Nonato

et al. 2024

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

The aim of this study was to synthesize and characterize Cellulose Acetate (CA) porous scaffolds using the electrospinning technique associated with Hydroxyapatite (HA) and different concentrations of graphene oxide (GO), for advanced regenerative therapies application. The scaffolds were categorized into four distinct groups based on their composition: (1) Pure CA scaffolds; (2) CAHA scaffolds; (3) CAHAGO 1.0% scaffolds; (4) CAHAGO 1.5% scaffolds. Transmission Electron Microscopy (TEM) was used for the characterization of the nanocomposite. The scaffolds were analyzed by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM/EDS), and in vitro cell viability assays (WST). For the biological test analysis of Variance (two-way) was used, followed by Tukey’s post-test (α = 0.05). The TEM analysis allowed for the visualization of the deposition of HA on the graphene sheets, confirming the synthesis of the nanocomposite. XRD revealed the predominant presence of CaP phases in the CAHA, CAHAGO 1.0%, and CAHAGO 1.5% groups, underscoring the inherent mineral composition of the scaffolds. FTIR demonstrated cellulose characteristics and PO4 bands in the groups containing HA, confirming the effective incorporation of this material. Raman spectroscopy revealed distinct peaks in the GO groups, conclusively verifying the successful integration of graphene into the scaffold matrix. The micrographs showcased irregular pores filling the entire surface, arising from the intricate overlapping of fibers during scaffold formation. Importantly, all scaffolds exhibited excellent cell viability in the conducted assays. A proliferation process was observed in CAHA and CAHAGO 1.5% groups after 48 h ( p < 0.05). In conclusion, the scaffolds synthesized hold significant promise in the realm of tissue engineering and provide a fresh perspective on the possibilities for regenerative therapies.

show abstract

Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

Menezes,

Navarro da Rocha,

Carajelescov Nonato

et al. 2024

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

show abstract

“…One property of polyphenols is free radical scavenging, 31 which is a key factor in building an antioxidant microenvironment in skin wounds. DPPH was used to verify the hyrogels’ in vitro free radical scavenging ability.…”

Section: Resultsmentioning

confidence: 99%

An injectable photocuring silk fibroin-based hydrogel for constructing an antioxidant microenvironment for skin repair

Liu,

Wang,

Liu

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

show abstract

Polyphenolic-modified cellulose acetate membrane for bone regeneration through immunomodulation

Cited by 23 publications

References 70 publications

Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies

An injectable photocuring silk fibroin-based hydrogel for constructing an antioxidant microenvironment for skin repair

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Contact Info

Product

Resources

About