Polyphenols: A first evidence in the synergism and bioactivities

Mitra, Saikat; Tareq, Abu Montakim; Das, Rajib; Emran, Talha Bin; Nainu, Firzan; Chakraborty, Arka; Ahmad, Islamudin; Tallei, Trina Ekawati; Idris, Abubakr M.; Simal-Gándara, Jesús

doi:10.1080/87559129.2022.2026376

Cited by 76 publications

(54 citation statements)

References 127 publications

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“…With concomitant suppression of the voltage activated Ca 2+ channel, it can either enhance chloride conductivity or enhance GABA-induced chloride conduction [ 48 , 49 ]. Stimulation of protein kinase C, neuroprotective effects against ROS; boosting nicotinic receptors that also enhance perception and cognition; energetic and continuing to improve the function of the nervous; enabling the passing receptor calcium channels in the nerve cell membrane that have neuropharmacological influences are some of the suggested modes of action for alkaloids, flavonoids, steroids, and terpenoids [ 50 – 56 ]…”

Section: Discussionmentioning

confidence: 99%

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

Islam

Mitra

Nafady

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.

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Section: Discussionmentioning

confidence: 99%

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

Islam

Mitra

Nafady

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The water extract did not stimulate insulin receptor protein expression, but the cinnamon polyphenol did. GLUT4 protein expression increased when both water extract and cinnamon polyphenol were administered in the therapy [ 132 ]. TTP is an inflammatory protein whose mRNA expression was shown to be elevated in a mouse fibroblast cell line after insulin therapy.…”

Section: Phytogenic Compoundsmentioning

confidence: 99%

“…Resveratrol is a polyphenol that is found in the extract of Vitis vinifera [ 149 ]. It possesses a wide range of bioactivities, including hepatoprotective, anti-cancer, anti-inflammatory, immunomodulatory, antidiabetic, and other properties [ 132 , 150 , 151 ]. In many rodent models, resveratrol has been shown to treat diabetes [ 152 , 153 ] and its complications [ 154 , 155 , 156 , 157 , 158 , 159 ].…”

Section: Phytogenic Compoundsmentioning

confidence: 99%

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

et al. 2022

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Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people’s lives. Diabetes is a metabolic and endocrine illness set apart by hyperglycemia and glucose narrow-mindedness because of insulin opposition. Heftiness is a typical, complex, and developing overall wellbeing worry that has for quite some time been connected to significant medical issues in individuals, all things considered. Because of the wide variety and low adverse effects, herbal products are an important hotspot for drug development. Synthetic compounds are not structurally diverse and lack drug-likeness properties. Thus, it is basic to keep on exploring herbal products as possible wellsprings of novel drugs. We conducted this review of the literature by searching Scopus, Science Direct, Elsevier, PubMed, and Web of Science databases. From 1990 until October 2021, research reports, review articles, and original research articles in English are presented. It provides top to bottom data and an examination of plant-inferred compounds that might be utilized against heftiness or potentially hostile to diabetes treatments. Our expanded comprehension of the systems of activity of phytogenic compounds, as an extra examination, could prompt the advancement of remedial methodologies for metabolic diseases. In clinical trials, a huge number of these food kinds or restorative plants, as well as their bioactive compounds, have been shown to be beneficial in the treatment of obesity.

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“…According to researchers, E. purpurea increases the number of natural killer cells in the mice tested. In the future, E. purpurea could be used as an anticancer medication ( Table 1 ) [ 175 ]. Flavonoids in echinacea help to boost the immune system.…”

Section: Natural Compounds Against Breast Cancermentioning

confidence: 99%

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Islam

Nafady

et al. 2022

Molecules

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Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.

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Polyphenols: A first evidence in the synergism and bioactivities

Cited by 76 publications

References 127 publications

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

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