Polyphenols as Potent Epigenetics Agents for Cancer

Rajendran, Peramaiyan; Abdelsalam, Salaheldin A.; Renu, Kaviyarasi; Vishnupriya, V.; Ammar, Rebaï Ben; Ahmed, Emad A.

doi:10.3390/ijms231911712

Cited by 50 publications

(26 citation statements)

References 162 publications

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“…Polyphenols are very well-known antioxidants and thousands of scientific works have verified this activity for these ubiquitous natural compounds. A countless number of them, including many of those encountered in BP, have been conducted either at experimental or clinical levels, and have concerned many types of human diseases [ 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ]. The development of these studies being beyond the scope of our current paper, we will not develop these results here.…”

Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved in the genesis and development of many world-scale public health burdens, such as metabolic and cardiovascular diseases. In recent years, bee pollen is emerging as a scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix is being extensively studied, and has proven to be a very rich and well-balanced nutrient pool. In this work, we reviewed the available evidence on the interest in bee pollen as a nutrient source. We mainly focused on bee pollen richness in nutrients and its possible roles in the main pathophysiological processes that are directly linked to nutritional imbalances. This scoping review analyzed scientific works published in the last four years, focusing on the clearest inferences and perspectives to translate cumulated experimental and preclinical evidence into clinically relevant insights. The promising uses of bee pollen for malnutrition, digestive health, metabolic disorders, and other bioactivities which could be helpful to readjust homeostasis (as it is also true in the case of anti-inflammatory or anti-oxidant needs), as well as the benefits on cardiovascular diseases, were identified. The current knowledge gaps were identified, along with the practical challenges that hinder the establishment and fructification of these uses. A complete data collection made with a major range of botanical species allows more robust clinical information.

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Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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“…It has been reported that RV can act epigenetically to modulate autophagy in cancer [ 22 - 24 ], and it is known that the secretions in the tumor microenvironment can epigenetically modulate autophagy to drive tumor dormancy [ 25 ]. In a separate study, we demonstrated that RV could keep ovarian cancer cells grown as 3D spheroids (a proxy of peritoneal metastatic colonies) in a dormant state even in the presence of IL-6, and this effect was due to the down-regulation of miR-1305 and concomitant re-expression of its target ARH-I (DIRAS3), which then rescued BECLIN-1-dependent autophagy [ 26 ].…”

Section: Main Subjectsmentioning

confidence: 99%

Resveratrol Promotes Self-digestion to Put Cancer to Sleep

Ferraresi,

Thongchot,

Isidoro

2024

J Cancer Prev

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Resveratrol, a natural polyphenol present in a variety of food stuff, has been shown to exert preventive and curative anticancer activity in several in vitro and in vivo models. Such chemopreventive/anticancer activity has been linked to biochemical and epigenetic modifications of multiple pathways involved in carcinogenesis and metastasization. In this commentary, we focus on the recent work done in our laboratory showing that resveratrol has potential to prevent and cure cancer by promoting epigenetic-mediated autophagy-dependent tumor dormancy, an effect associated with re-education of the cancer-associated fibroblasts and reduced production of inflammatory cytokines in the tumor microenvironment. The clinical translation of the current knowledge on resveratrol anticancer activity is also discussed.

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“…Among the mechanisms of anticancer activity of polyphenols are antioxidant/prooxidant activity, inhibition of specific protein kinases and other enzymes and the resulting changes in cellular signalling, inhibition of angiogenesis, estrogenic/antiestrogenic activity, antiproliferation, induction of detoxification enzymes, regulation of the host immune system, and anti-inflammatory activity [ 79 , 108 , 109 , 110 ]. Some polyphenols (e.g., quercetin, kaempferol, curcumin, resveratrol, and EGCG) downregulate the expression of histone deacetylases; this means that these compounds exert anticancer action by restoring epigenetic alterations in cancer cells as well as by DNA methylation and histone modifications which may prevent normal cells from turning into tumours [ 111 ]. It should be underlined that sirtuins (from SIRT1 to SIRT7) are enzymes belonging to class III HDAC (NAD+ −dependent histone deacetylases).…”

Section: Polyphenols In Disease Prevention and Treatmentmentioning

confidence: 99%

Possible Side Effects of Polyphenols and Their Interactions with Medicines

Duda-Chodak

Tarko

2023

Molecules

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Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, as with any chemical substance, depending on the conditions, dose, and interactions with the environment, it is possible for polyphenols to also exert harmful effects. This review presents a comprehensive current state of the knowledge on the negative impact of polyphenols on human health, describing the possible side effects of polyphenol intake, especially in the form of supplements. The review begins with a brief overview of the physiological role of polyphenols and their potential use in disease prevention, followed by the harmful effects of polyphenols which are exerted in particular situations. The individual chapters discuss the consequences of polyphenols’ ability to block iron uptake, which in some subpopulations can be harmful, as well as the possible inhibition of digestive enzymes, inhibition of intestinal microbiota, interactions of polyphenolic compounds with drugs, and impact on hormonal balance. Finally, the prooxidative activity of polyphenols as well as their mutagenic, carcinogenic, and genotoxic effects are presented. According to the authors, there is a need to raise public awareness about the possible side effects of polyphenols supplementation, especially in the case of vulnerable subpopulations.

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Polyphenols as Potent Epigenetics Agents for Cancer

Cited by 50 publications

References 162 publications

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Resveratrol Promotes Self-digestion to Put Cancer to Sleep

Possible Side Effects of Polyphenols and Their Interactions with Medicines

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