Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities

Abstract

Xanthoceras sorbifolia Bunge. is used in traditional medicine in North China. To evaluate the anti-tumor and radical-scavenging activities of X. sorbifolia husks polyphenols and determine their structure-activity relationships, 37 polyphenols 1-37 were obtained by bioassay-guided fractionation. Two new compounds 1-2, and compounds 5, 6, 8, 9, 11, 14-17, 21-25, 27-29, 31, 33, 34, 36, and 37 were isolated from the genus Xanthoceras for the first time. Compounds 1-37 did not show strong cytotoxicity against the four tested tumor cell lines (A549, HepG2, MGC-803, and MFC) compared to paclitaxel and under the conditions tested in the anti-tumor assay, but compounds 3, 4, 7, 8, 10, 18-20, 25, 26, 29, 30, 32, and 35 exhibited stronger radical-scavenging activity than ascorbic acid in a 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay. This was the first report on the anti-tumor and radical-scavenging activities of the polyphenols isolated from X. sorbifolia husks. Overall, the present study contributed valuable information concerning X. sorbifolia husks use in medicine and pharmacology.

Leaves of Duroia longiflora: Isolation of a Biflavanoid and Histochemical Analysis

“…Only 2 studies reporting the presence of this substance were found in literature, both in Sapindaceae species: in Litchi chinensis seeds 15 and in Xanthoceras sorbifolium husks. 16 Duroia species suffers from herbivory and the species D. hirsuta and D. saccifera developed myrmecophily association, which creates protection against herbivory. 17 Duroia macrophylla and D. longiflora lack ant symbiosis, which forced them to find another way to protect themselves from herbivory and fungal pathogens.…”

Special Issue “Structure–Activity Relationship of Natural Products”

“…The antioxidant properties of ferulates was investigated by Karamac et al [ 7 ] whereas the free radical scavenging activity of soy isoflavone glycosides (Daidzin and Genistin)—and their 3’hydroxylated derivatives—was reported by Chiang et al [ 8 ]. Such radical-scavenging activity, together with anti-tumor effects, were further described for Xanthoceras sorbifolia bunge/yellow horn plant polyphenols by Yang et al [ 9 ]. Another interesting research article by Singh et al [ 10 ] focused on the potential of glycyrrhizic acid to help both heart contractions and blood pressure.…”

Physiological and transcriptomic analyses of yellow horn (Xanthoceras sorbifolia) provide important insights into salt and saline-alkali stress tolerance

“…Xanthoceras sorbifolia , commonly known as yellow horn, is the only validated species in the genus Xanthoceras within the family Sapindaceae [ 28 ]. It is a woody deciduous shrub or small tree that is widely distributed in North China [ 29 ].…”