Abstract:Many bacterial species, including Escherichia coli (E. coli), utilize the enzyme polyphosphate kinase (PPK) to synthesize polyphosphate (polyP) in response to biological stresses. Multiple studies have shown that impairing PPK activity impairs bacterial pathogenicity and survival. Further, no PPK homolog has been identified in mammalian species, making it a promising therapeutic target. While the structure, kinetics, and mechanism of PPK is well‐characterized, its regulation is poorly understood. We previously… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.