Polyphosphate Synthesis as a Target for Novel Antibiotics

Ellagic acid derivatives from Terminalia chebula Retz. increase the susceptibility of Pseudomonas aeruginosa to stress by inhibiting polyphosphate kinase

“…However, their nature has not been disclosed (Chavez et al . ). Aptamer‐mediated PPK2 inhibitor has been shown to control Myco.…”

“…However, these compounds have failed to emerge as good drugs against human infections (Chavez et al . ).…”

“…PPK inhibitors are being screened from chemical libraries using the well established crystal structure of full length PPK1 of Escherichia coli (Chavez et al 2011). Five compounds from the ICOS' chemical library were found to inhibit PPK1 activity in E. coli.…”

“…Five compounds from the ICOS' chemical library were found to inhibit PPK1 activity in E. coli. However, their nature has not been disclosed (Chavez et al 2011). Aptamermediated PPK2 inhibitor has been shown to control Myco.…”

“…tuberculosis virulence (Shum et al 2011) whereas AMPPNP (b-c-imidoadenosine 5-phosphate), an analogue of adenosine 3-phosphate, inhibited PPK1 by preventing dimerization in E. coli (Zhu et al 2005). However, these compounds have failed to emerge as good drugs against human infections (Chavez et al 2011).…”