Polypyrrole-based nanotheranostic agent for MRI guided photothermal-chemodynamic synergistic cancer therapy

Zhou, Bangyi; Yin, Chenhui; Feng, Qiang; Wu, Yi-Ting; Pan, Xiaoyu; LIU, Chuang; Tian, Jinjin; Geng, Siqi; Wang, Kexin; Xing, Jie; Cao, Yi; Shou, Pingbo; Yu, Zhangsen; Wu, Aiguo

doi:10.1039/d1nr05508a

Cited by 22 publications

(10 citation statements)

References 38 publications

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“…Based on the photothermal conversion ability of PTT, multifunctional nanoparticles are introduced chemodynamics to enhance the photothermal performance by catalyzing H 2 O 2 molecules. [452][453][454] For example, Li et al 188 designed a multifunctional nanosystem (BCG) based on Cu-modified black phosphorous quantum dots (BPQDs) to load glucose oxidase (GOD). BPQDs released Cu 2+ to induce GSH depletion, and transformed Cu 2+ into cuprous ions for CDT.…”

Section: Synergistic Therapymentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Synergistic Therapymentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…Among the various CDT-combined approaches under investigation, CDT/PTT has shown to be a highly efficient and relatively safe paradigm [ 36 , 37 ]. PTT utilizes diverse photothermal agents (PTAs) to harvest NIR light and rapidly converts the light energy into heat to destroy tumors [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

et al. 2022

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Monomodal cancer therapies are often unsatisfactory, leading to suboptimal treatment effects that result in either an inability to stop growth and metastasis or prevent relapse. Thus, synergistic strategies that combine different therapeutic modalities to improve performance have become the new research trend. In this regard, the integration of photothermal therapy (PTT) with chemodynamic therapy (CDT), especially PTT/CDT in the second near-infrared (NIR-II) biowindow, has been demonstrated to be a highly efficient and relatively safe concept. With the rapid development of nanotechnology, nanoparticles can be designed from specific elements, such as Fe, that are equipped with both PTT and CDT therapeutic functions. In this review, we provide an update on the recent advances in Fe-based nanoplatforms for combined PTT/CDT. The perspectives on further improvement of the curative efficiency are described, highlighting the important scientific obstacles that require resolution in order to reach greater heights of clinical success. We hope this review will inspire the interest of researchers in developing novel Fe-based nanomedicines for multifunctional theranostics.

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“…7 At present, PTT has been applied to the in vitro and in vivo biomedical researches. [8][9][10][11][12] With the continuous development of research related to PTT, majority of PTAs have been developed and studied, including platinum, Au nanoparticles (NPs), MoSe 2 , Indocyanine Green (ICG), new Indocyanine Green (IR820) and so on. [13][14][15][16][17] Although, a variety of PTAs have been utilized, there is still a great demand for photothermal materials with good biosafety and photothermal property.…”

Section: Introductionmentioning

confidence: 99%

A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer

Alifu

et al. 2022

Nanoscale Adv.

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Polypyrrole-based nanotheranostic agent for MRI guided photothermal-chemodynamic synergistic cancer therapy

Abstract: Polypyrrole nanoparticles (PPy) have been widely studied in tumor photothermal therapy (PTT) for their significant photostability, good biocompatibility, and excellent photothermal performance. Herein, we reported bovine serum albumin (BSA) stabilized...

Cited by 22 publications

References 38 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer

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