Polysaccharide-based formulations as potential carriers for pulmonary delivery – A review of their properties and fates

Valente, Sara A.; Silva, Lisete M.; Lopes, Guido R.; Sarmento, Bruno; Coimbra, Manuel A.; Passos, Claúdia P.

doi:10.1016/j.carbpol.2021.118784

Cited by 27 publications

(16 citation statements)

References 238 publications

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“…Liposomes were composed of DPPC, cholesterol and DSPE-PEG2000 [ 50 , 51 ] at molar ratio of (60:35:5), respectively. DPPC and cholesterol were selected since they are a naturally occurring components of the pulmonary surfactant [ 52 ] ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Lung targeted liposomes for treating ARDS

Raviv

Alyan

Егоров

et al. 2022

Journal of Controlled Release

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Section: Resultsmentioning

confidence: 99%

Lung targeted liposomes for treating ARDS

Raviv

Alyan

Егоров

et al. 2022

Journal of Controlled Release

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“…This well-established technique for generating dry powdered products usually produces spherical particles as a result of the liquid surface tension upon drying of the atomized droplets. However, by adjusting the conditions under which spray drying is carried out, the particles can have different shapes, densities, geometric diameters and surface properties [ 57 ]. In Fig.…”

Section: Mps Based On Polysaccharidesmentioning

confidence: 99%

“…Polysaccharides used in pulmonary drug delivery among others are chitosan, hyaluronic acid, locust bean gum, fucoidan, chondroitin sulfate, alginate, carrageenan and dextran [ 57 ]. Examples of polysaccharides, their applications and their properties are shown in Table 2 .…”

Section: Mps Based On Polysaccharidesmentioning

confidence: 99%

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Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Knap

Kwiecień

Reczyńska-Kolman

et al. 2022

Regenerative Biomaterials

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Inhalation-administrated drugs remain an interesting possibility of addressing pulmonary diseases. Direct drug delivery to the lungs allows one to obtain high concentration in the site of action with limited systemic distribution, leading to a more effective therapy with reduced required doses and side effects. On the other hand, there are several difficulties in obtaining a formulation that would meet all the criteria related to physicochemical, aerodynamic, and biological properties, which is the reason why only very few of the investigated systems can reach the clinical trial phase and proceed to everyday use as a result. Therefore, we focused on powders consisting of polysaccharides, lipids, proteins, or natural and synthetic polymers in the form of microparticles that are delivered by inhalation to the lungs as drug carriers. We summarized the most common trends in research today to provide the best dry powders in the right fraction for inhalation that would be able to release the drug before being removed by natural mechanisms. This review paper addresses the most common manufacturing methods with novel modifications, pros and cons of different materials, drug loading capacities with release profiles, and biological properties such as cytocompatibility, bactericidal, or anticancer properties.

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“…Currently, the carriers for therapeutic molecules are mostly fabricated using natural polymers due to their abundance, versatility and lower probability of immunogenic responses [25]. Sodium alginate has been extensively investigated for pulmonary drug delivery due to its muco-and bio-adhesive properties, biocompatible and biodegradable nature and nontoxic characteristics [26,27].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Microparticles: Synthesis, Characterization and In Vitro Evaluation for Pulmonary Delivery of Rifampicin

et al. 2022

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Rifampicin, a potent broad-spectrum antibiotic, remains the backbone of anti-tubercular therapy. However, it can cause severe hepatotoxicity when given orally. To overcome the limitations of the current oral therapy, this study designed inhalable spray-dried, rifampicin-loaded microparticles using aloe vera powder as an immune modulator, with varying concentrations of alginate and L-leucine. The microparticles were assessed for their physicochemical properties, in vitro drug release and aerodynamic behavior. The spray-dried powders were 2 to 4 µm in size with a percentage yield of 45 to 65%. The particles were nearly spherical with the tendency of agglomeration as depicted from Carr’s index (37 to 65) and Hausner’s ratios (>1.50). The drug content ranged from 0.24 to 0.39 mg/mg, with an association efficiency of 39.28 to 96.15%. The dissolution data depicts that the in vitro release of rifampicin from microparticles was significantly retarded with a higher L-leucine concentration in comparison to those formulations containing a higher sodium alginate concentration due to its hydrophobic nature. The aerodynamic data depicts that 60 to 70% of the aerosol mass was emitted from an inhaler with MMAD values of 1.44 to 1.60 µm and FPF of 43.22 to 55.70%. The higher FPF values with retarded in vitro release could allow sufficient time for the phagocytosis of synthesized microparticles by alveolar macrophages, thereby leading to the eradication of M. tuberculosis from these cells.

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Polysaccharide-based formulations as potential carriers for pulmonary delivery – A review of their properties and fates

Cited by 27 publications

References 238 publications

Lung targeted liposomes for treating ARDS

Lung targeted liposomes for treating ARDS

Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Polymeric Microparticles: Synthesis, Characterization and In Vitro Evaluation for Pulmonary Delivery of Rifampicin

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