Polysaccharide-based hydrogels containing herbal extracts for wound healing applications

Abazari, Morteza; Akbari, Tayebeh; Hasani, Mahdiye; Sharifikoloue, Elham; Raoufi, Mohammad; Foroumadi, Alireza; Sharifzadeh, Mohammad; Firoozpour, Loghman; Khoobi, Mehdi

doi:10.1016/j.carbpol.2022.119808

Cited by 54 publications

(18 citation statements)

References 95 publications

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“…It is also confirmed in previous studies that GNPs with anti-inflammatory and antioxidant activities accelerate cutaneous wound healing. 30,37,59 Furthermore, in the present study, a combination of collagen 19,60 and saffron components 61,62 associated with the GNPs improved the healing efficiency of the prepared scaffolds.…”

Section: Resultssupporting

confidence: 59%

Co-electrospun PCL-collagen nanofibers containing saffron-synthesized gold nanoparticles as an antioxidant wound dressing

Javadi,

Derakhshan,

Asghari

et al. 2023

Proc Inst Mech Eng H

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Oxidant environment and inflammation are the leading cause of chronic wounds such as diabetic ulcers. A dressing containing antioxidants would ensure accelerated wound healing. In this study, electrospun gold nanoparticle (GNP)-embedded nanofibers were developed. GNPs (about 7 nm) were synthesized using saffron extract as a reducing and capping agent (GNP-EXT). For comparison, nanoparticles of the same size were also synthesized using citrate (GNP-CIT). Nanoparticle colloids showed a zeta potential of -27 mV. FTIR confirmed the presence of the extract molecules on the nanoparticles. DPPH assay demonstrated the significant radical scavenging properties of the GNP-EXT. The effect of nanoparticles on the viability of NIH3T3 mouse fibroblast cells was evaluated with an MTT assay that showed no significant toxicity of nanoparticles even in the highest concentration of 250 ppm. Then poly (ɛ-caprolactone) (PCL)- Collagen nanofibers containing GNPs were electrospun. By using SEM, TEM, ATR-FTIR, and contact angle measurement, the nanofibers were characterized. Proper cell adhesion and spreading was observed on nanofibers by SEM and Alamar blue assay illustrated appropriate cyto-compatibility on the obtained nanofibers after 5 days of cell seeding. Wound healing assay also confirmed the cell supporting properties and biocompatibility. The results suggest that saffron-synthesized GNP-loaded nanofibers would be considered as potential wound dressings.

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Section: Resultssupporting

confidence: 59%

Co-electrospun PCL-collagen nanofibers containing saffron-synthesized gold nanoparticles as an antioxidant wound dressing

Javadi,

Derakhshan,

Asghari

et al. 2023

Proc Inst Mech Eng H

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“…Typical modifications such as polymerization, etherification, oxidation, crosslinking, and graft copolymerization have been explored to develop modified carbohydrates, especially polysaccharides, and have been potential candidates for wound care. Polysaccharides-based hydrogels and nanocomposites ( Figure 5 ) show a three-dimensional network and other beneficial properties of interest for the delivery of different formulations for oral and topical applications [ 96 ].…”

Section: Treatments For Topical Infected Woundsmentioning

confidence: 99%

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

et al. 2023

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Despite the fact that skin has a stronger potential to regenerate than other tissues, wounds have become a serious healthcare issue. Much effort has been focused on developing efficient therapeutical approaches, especially biological ones. This paper presents a comprehensive review on the wound healing process, the classification of wounds, and the particular characteristics of each phase of the repair process. We also highlight characteristics of the normal process and those involved in impaired wound healing, specifically in the case of infected wounds. The treatments discussed here include proteins, lipids, and carbohydrates. Proteins are important actors mediating interactions between cells and between them and the extracellular matrix, which are essential interactions for the healing process. Different strategies involving biopolymers, blends, nanotools, and immobilizing systems have been studied against infected wounds. Lipids of animal, mineral, and mainly vegetable origin have been used in the development of topical biocompatible formulations, since their healing, antimicrobial, and anti-inflammatory properties are interesting for wound healing. Vegetable oils, polymeric films, lipid nanoparticles, and lipid-based drug delivery systems have been reported as promising approaches in managing skin wounds. Carbohydrate-based formulations as blends, hydrogels, and nanocomposites, have also been reported as promising healing, antimicrobial, and modulatory agents for wound management.

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“…Good biocompatibility, easily controlled administration, and sustained drug release have enabled hydrogels to play important roles in cancer therapy ( Norouzi et al, 2016 ; Sonker et al, 2021 ; Xiao et al, 2021 ). To date, hydrogels have been adopted as drug delivery systems in wound healing ( Abazari et al, 2022 ; Zhao P. et al, 2022 ; Liu et al, 2022 ), arthritis therapy ( Zhang M. et al, 2022 ; Zhao Y. P. et al, 2022 ), ophthalmic disease ( Lin et al, 2019 ; Lynch et al, 2020 ; Akulo et al, 2022 ; Das et al, 2022 ), skin disease ( Jiang T. et al, 2018 ; Yuan et al, 2020 ), vaginal infections ( Perinelli et al, 2018 ; Dos Santos et al, 2020 ), and other applications ( Jacob et al, 2019 ). Unfortunately, there have been relatively few studies on the effect of drugs on meniscus repair.…”

Section: Extrinsic Substance-delivery Hydrogelsmentioning

confidence: 99%

“…As prominent biomaterials, hydrogels have received much attention for their good biocompatibility, reduction of shear force, and strong plasticity ( Longo et al, 2012 ). They can be used in biomedicine under reasonable structural and functional design ( Abazari et al, 2022 ; Li et al, 2022d ). Modification of hydrogels with different responsive materials is a common technique in tissue engineering to optimize the physical and chemical properties of hydrogels ( Zhang L. et al, 2022 ; Zhao P. et al, 2022 ; Cao et al, 2022 ; Zhang Q. et al, 2022 ; Liu et al, 2022 ; Shao et al, 2022 ; Shen et al, 2022 ; Wu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Applications and prospects of different functional hydrogels in meniscus repair

Jin

Liu

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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The meniscus is a kind of fibrous cartilage structure that serves as a cushion in the knee joint to alleviate the mechanical load. It is commonly injured, but it cannot heal spontaneously. Traditional meniscectomy is not currently recommended as this treatment tends to cause osteoarthritis. Due to their good biocompatibility and versatile regulation, hydrogels are emerging biomaterials in tissue engineering. Hydrogels are excellent candidates in meniscus rehabilitation and regeneration because they are fine-tunable, easily modified, and capable of delivering exogenous drugs, cells, proteins, and cytokines. Various hydrogels have been reported to work well in meniscus-damaged animals, but few hydrogels are effective in the clinic, indicating that hydrogels possess many overlooked problems. In this review, we summarize the applications and problems of hydrogels in extrinsic substance delivery, meniscus rehabilitation, and meniscus regeneration. This study will provide theoretical guidance for new therapeutic strategies for meniscus repair.

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Polysaccharide-based hydrogels containing herbal extracts for wound healing applications

Cited by 54 publications

References 95 publications

Co-electrospun PCL-collagen nanofibers containing saffron-synthesized gold nanoparticles as an antioxidant wound dressing

Co-electrospun PCL-collagen nanofibers containing saffron-synthesized gold nanoparticles as an antioxidant wound dressing

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

Applications and prospects of different functional hydrogels in meniscus repair

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