Polysaccharide fraction from the Indian mistletoe, Dendrophthoe falcata (L.f.) Ettingsh enhances innate immunity and disease resistance in Oreochromis niloticus (Linn.)

Shalini, Konda Subramanian; Yengkhom, Omita; Subramani, Parasuraman Aiya; Michael, R. Dinakaran

doi:10.1016/j.fsi.2019.03.008

Cited by 19 publications

(6 citation statements)

References 69 publications

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“…During the previous decade, the outbreak of infectious diseases has emerged as a major limiting factor for aquaculture expansion which causes massive mortality and economic losses (Shalini et al 2019). An important strategy used to address this problem is the administration of antibiotics (Rico et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…However, the administration of antibiotic drugs may pose several side-effects such as the occurrence of antibiotic resistance in bacterial pathogens (Lunden et al 1998), residue in sh tissues (Harikrishnan et al 2009), and reduction of sh health (Shalini et al 2019). For instance, OTC is found to induce oxidative stress and liver malfunctioning.…”

Section: Introductionmentioning

confidence: 99%

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The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

Moradi

Javanmardi

Gholamzadeh

et al. 2022

Fish Physiol Biochem

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This experiment aimed to determine the possible bene cial effects of dietary ascorbic acid (AA) on hematological indices, immune responses, and antioxidative capacity of Oncorhynchus mykiss treated with antibiotic oxytetracycline (OTC). 150 sh were divided evenly among ve experimental groups (30 sh of each, in 3 replicates) receiving diets containing OTC (0 and 100 mg per kg sh weight) and AA (100, 200, 400 and 800 mg per kg sh diet) for 28 days. Treatments include group A or control (100 mg AA without OTC), group B (100 mg AA with OTC), group C (200 mg AA with OTC), group D (400 mg AA with OTC), and group E (800 mg AA with OTC). The results obtained showed that the hematological indices (red blood cells, white blood cells, hematocrit, hemoglobin and neutrophils), immunological parameters (plasma lysozyme, plasma complement and skin mucus alkaline phosphatase activities), and antioxidant enzymes activities (superoxide dismutase and catalase) were signi cantly decreased by OTC in O. mykiss fed control diet (P < 0.05). The results also revealed that OTC signi cantly increased the activity of biochemical enzymes (aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) in the plasma of O. mykiss fed control diet (P < 0.05). However, in comparison to the control diet, feeding sh with higher amounts of AA (400 and 800 mg/kg diet) signi cantly restored the hematological, immunological, and antioxidative responses in OTC treated groups (p < 0.05). These ndings show that the dietary supplementation of AA at 400 or 800 mg/kg diet is bene cial in relieving O. mykiss from OTC-induced oxidative stress and immunosuppression.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

Moradi

Javanmardi

Gholamzadeh

et al. 2022

Fish Physiol Biochem

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“…The whole DF is used to treat cooling, bitter, astringent, aphrodisiac, narcotic, fertility, cancer, and diuretic in indigenous medicine ( Bhagat and Kondawar, 2019 ; Reddy et al, 2019 ). Also, the whole DF is used as a cooling, astringent, aphrodisiac, narcotic, and diuretic agent in the traditional Indian system of medicine ( Shalini et al, 2019a ). Additionally, the ethnomedical properties of DF are documented in some countries.…”

Section: Traditional Medical Usesmentioning

confidence: 99%

“…Currently, polysaccharides of DF have been used as dietary supplements. Polysaccharides extracted from DF leaves growing on Azadirachta indica A.Juss., for example, were fed to fish as a supplemented diet (1%), and the results showed an increase in lysozyme and TNF-α expression, as well as an increase in relative survival percentage compared to the positive control group (0.1% MacroGard™) ( Shalini et al, 2019a ). The tilapias were fed polysaccharides isolated from DF leaves growing on Azadirachta indica A.Juss.…”

Section: Pharmacologymentioning

confidence: 99%

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

et al. 2023

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Dendrophthoe falcata (L.f.) Ettingsh. (DF) and Dendrophthoe pentandra (L.) Miq. (DP) have been traditionally used for the treatment of various ailments, such as cancer, ulcers, asthma, paralysis, skin diseases, tuberculosis, and menstrual troubles, in the ethnomedicinal systems of India and Indonesia. Currently, the chemical structures of 46 compounds have been elucidated from DF and DP, including flavonoids, triterpenes, tannins, steroids, open-chain aliphatics, benzyl derivates, and cyclic chain derivatives. In vitro assays have revealed their anti-tumor and anti-microbial activities. In vivo studies have unraveled their pharmacological properties against tumors, depression, fertility disorders, inflammatory responses, and so on. Additionally, their weak toxicity to rats and brine shrimp, as well as their promising applications for pharmaceutical preparations and combined medication, were also revealed. Herein, we not only recapitulated traditional medical uses, phytochemistry, pharmacology, toxicity, and applications of DF and DP but also discussed current research limitations and future perspectives, which are instructive for those interested in them and are committed to advancing parasitic plants to the Frontier of phytomedicine. We highlighted that DF and DP will become promising medical plants rather than being discarded as notorious pests, provided that more and deeper research is undertaken.

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“…Polysaccharides, isolated from various natural sources, possess diverse biological and pharmacological activities including immunomodulatory, anti-inflammatory, antioxidant, antidiabetic, antimutagenic, antiviral, and antitumor (Guo et al, 2019;Shalini et al, 2019;Mohammed et al, 2021). Notably, numerous studies have shown that polysaccharides, especially from traditional Chinese medicine, exerted significant immune regulation activities and widely applied in pharmaceutical fields (Li C. et al, 2021;Wang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Achyranthes bidentata Polysaccharide Activates Nuclear Factor-Kappa B and Promotes Cytokine Production in J774A.1 Cells Through TLR4/MyD88 Signaling Pathway

et al. 2021

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Achyranthes bidentata Blume, a traditional Chinese medicine, is widely acknowledged for its function of invigorating the liver and kidneys and as a stranguria-relieving diuretic and used in the treatment of edema, gonorrhea, and other diseases. Polysaccharide (ABPS), isolated from Achyranthes bidentata Blume, has been demonstrated to have multiple biological activities including immunomodulatory effects. However, the mechanisms underlying the effects of ABPS have not been fully investigated. The present study is conducted to explore the underlying mechanism of immunomodulatory activities of ABPS. Results showed that ABPS significantly increased the secretion of IL-1β and TNF-α in J744 A.1 cells. Nitric oxide (NO) also significantly increased after ABPS treatment. The special antibodies (Toll-like receptor 4 (TLR4) antibody and CD14/TLR4 antibody) significantly decreased the activation, while the Toll-like receptor 2 (TLR2) antibody could not abolish this activation. Meanwhile, pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of NF-κB, remarkably inhibited the secretion of IL-1β and TNF-α induced by ABPS in J744 A.1 cells. Western blotting (WB) and confocal laser scanning microscopy (CLSM) showed that ABPS promoted NF-κB translocation into the nucleus. Furthermore, the mRNA and protein expression of TLR4 and MyD88 were significantly increased after ABPS treatment. Taken together, these findings suggested that the immunomodulatory mechanism of ABPS was associated with the secretion of cytokines by stimulating the NF-κB pathway through TLR4/MyD88 signaling.

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Polysaccharide fraction from the Indian mistletoe, Dendrophthoe falcata (L.f.) Ettingsh enhances innate immunity and disease resistance in Oreochromis niloticus (Linn.)

Cited by 19 publications

References 69 publications

The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

Achyranthes bidentata Polysaccharide Activates Nuclear Factor-Kappa B and Promotes Cytokine Production in J774A.1 Cells Through TLR4/MyD88 Signaling Pathway

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