Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering

Yang, Qian; Peng, Jinrong; Xiao, Haitao; Xu, Xuewen; Qian, Zhiyong

doi:10.1016/j.carbpol.2021.118952

Cited by 139 publications

(82 citation statements)

References 190 publications

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“…Self-assembly and co-assembly for the preparation of biomaterials that include polysaccharides are promising since they do not involve the use of any toxic reactants or solvents [ 3 ]. Polysaccharides are very often involved in functional nanostructures for a range of applications such as the development of nanoparticles for drug and nutrient delivery [ 5 ], hydrogels for tissue regeneration [ 6 ] and films for food packaging [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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Polysaccharides are natural polymers with hydrophilic, biocompatible and biodegradable characteristics and have many opportunities in the food and pharmaceutical sectors. This review focuses on the field of nano and microstructures whose internal structure is based on networked polysaccharide chains in 3D i.e., polysaccharide nanogels (NGs) and microgels (MGs). As it is observed the number of articles on NGs and MGs in peer reviewed scientific journals has been increasing over the last two decades. At the same time, the relative contribution of polysaccharides in this field is gaining place. This review focuses on the different applied methods for the fabrication of a variety of polysaccharide-based NGs and MGs and aims to highlight the recent advances on the subject and present their potentials and properties with regards to their integration in aspects of medicinal and food sciences. The presentation of the recent advances in the application of polysaccharide NGs and MGs is divided in materials with potential as emulsion stabilizers and materials with potential as carriers of bioactives. For applications in the medical sector the division is based on the fabrication processes and includes self-assembled, electrostatically complexed/ionically crosslinked and chemically crosslinked NGs and MGs. It is concluded that many advances are expected in the application of these polysaccharide-based materials and in particular as nutrient-loaded emulsion stabilizers, viscosity modifiers and co-assembled structures in combination with proteins.

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Section: Introductionmentioning

confidence: 99%

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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“…Additionally, compatible with extrusion bioprinting are the coaxial and multi-material techniques, suitable for different sorts of applications. However, in general, the extrusion bioprinting approach has been used to fabricate 3D tissues and biological constructs including kidney [ 89 ], liver [ 98 ], blood vessels [ 93 ], tissue-engineered muscle [ 121 ], human intestinal tissue [ 97 ], adipose tissues [ 95 , 96 ], tracheal graft [ 37 ], tooth tissue [ 122 ], vascularized soft tissues [ 123 ], skin constructs [ 92 ], engineered neural tissues [ 126 ], brain tissue [ 127 ], renal tissue [ 128 ], cartilage tissue constructs [ 50 , 137 , 143 ], bone tissue [ 85 ] and other engineered structures [ 103 , 104 ].…”

Section: 3d Bioprinting and Process Parametersmentioning

confidence: 99%

“…Recognizing the potential widespread applications of hydrogels, several previous researchers have sought to undertake studies in the area [ 103 , 104 ]. For instance, the study of Kundu et al [ 103 ] explored the potential of employing different celluloses as natural biopolymers for applications including wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the study of Kundu et al [ 103 ] explored the potential of employing different celluloses as natural biopolymers for applications including wound healing. Similarly, Yang et al [ 104 ] studied the utilization of polysaccharide hydrogels in tissue engineering. Functionalization and modification of polysaccharides enabled the formation of hydrogels, and the introduction of versatile side groups helped to regulate cell behavior.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

142

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Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printability. This allows for immediate scaffold cellularization and generation of complex structures. The use of cell-laden inks or bio-inks provides the opportunity for enhanced cell differentiation for organ fabrication and regeneration. Recognizing the importance of such bio-inks, the current study comprehensively explores the state of the art of the utilization of bio-inks based on natural polymers (biopolymers), such as cellulose, agarose, alginate, decellularized matrix, in 3D bioprinting. Discussions regarding progress in bioprinting, techniques and approaches employed in the bioprinting of natural polymers, and limitations and prospects concerning future trends in human-scale tissue and organ fabrication are also presented.

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“…As an important material for tissue engineering, hydrogels interact with the surroundings of live organisms, acting as biomimetic scaffolds, creating a humid and biocompatible environment for cell growth, controlling the release of active ingredients, and enabling long-term survival and activation of living cells [ 282 , 283 ]. Particularly, polysaccharides-based hydrogels are ideal materials as scaffolds for cell support due to their excellent biocompatibility, biodegradability, and low immunogenicity [ 282 , 284 , 285 , 286 ].…”

Section: Application Of Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Lin

Jiao²,

Kermanshahi-pour

2022

Marine Drugs

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Hydrogels are three-dimensional crosslinked hydrophilic polymer networks with great potential in drug delivery, tissue engineering, wound dressing, agrochemicals application, food packaging, and cosmetics. However, conventional synthetic polymer hydrogels may be hazardous and have poor biocompatibility and biodegradability. Algal polysaccharides are abundant natural products with biocompatible and biodegradable properties. Polysaccharides and their derivatives also possess unique features such as physicochemical properties, hydrophilicity, mechanical strength, and tunable functionality. As such, algal polysaccharides have been widely exploited as building blocks in the fabrication of polysaccharide-based hydrogels through physical and/or chemical crosslinking. In this review, we discuss the extraction and characterization of polysaccharides derived from algae. This review focuses on recent advances in synthesis and applications of algal polysaccharides-based hydrogels. Additionally, we discuss the techno-economic analyses of chitosan and acrylic acid-based hydrogels, drawing attention to the importance of such analyses for hydrogels. Finally, the future prospects of algal polysaccharides-based hydrogels are outlined.

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Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering

Cited by 139 publications

References 190 publications

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

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