Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A2

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

“…Combination treatment with EP4A and low-dose BMP-2 efficiently activated bone cells to regenerate calvarial bone by forming both outer and inner cortical plates as well as bone marrow tissue and resulted in the formation of enough bone to cover the defects in calvarial bone. In another study, cationic physically-crosslinked nanogels composed of a hexadecyl group-bearing cycloamylose and spermine-modified cycloamylose to complex and co-deliver plasmid DNA along with phospholipaseA2 (PLA 2 ) [152]. As a lipolytic enzyme, PLA 2 catalyzes hydrolysis of a variety of different phospholipids.…”

Polymer nanogels: A versatile nanoscopic drug delivery platform

“…Physically crosslinked nanogels composed of hexadecyl groups-bearing cationic cycloamylose have been developed for delivery of pDNA (see Figure 32) [73]. Cycloamylose, a large cationic cyclodextrin ring, was employed for complexation of pDNA.…”

Effect of peptide content on the regulation of transgene expression by protein kinase Cα-responsive linear polyethylenimine-peptide conjugates

“…Various polymers, including linear/branched polyethylenimine (PEI) [4,5], polysaccharides [6], polypeptide [7], block copolymers [8], and branched polymers [9,10] have been investigated as gene carriers for cancer treatment. Cancer-specific gene delivery is one of the most important approaches to avoiding side effects.…”