Polysaccharides Derived from Saposhnikovia divaricata May Suppress Breast Cancer Through Activating Macrophages

Ding, Jingxian; Guo, Ying; Jiang, Xiaoliu; Li, Qingge; Li, Kai; Liu, Min; Fu, Wenbing; Cao, Yimei

doi:10.2147/ott.s267984

Cited by 11 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chitosan has a high concentration of reactive free protonable amino groups along the chitosan backbone, and due to the protonation of amino groups, it presents higher solubility in acid environment. These groups can be chemically modified in a variety of chemical reactions to enhance its solubility, biocompatibility and targeting activity ( de Sousa Victor et al, 2020 ; Ding et al, 2020 ). Consequently, chitosan has the potential to use in a variety of fields ( Aranaz et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Cancer has become a main public health issue globally. The conventional treatment measures for cancer include surgery, radiotherapy and chemotherapy. Among the various available treatment measures, chemotherapy is still one of the most important treatments for most cancer patients. However, chemotherapy for most cancers still faces many problems associated with a lot of adverse effects, which limit its therapeutic potency, low survival quality and discount cancer prognosis. In order to decrease these side effects and improve treatment effectiveness and patient’s compliance, more targeted treatments are needed. Sustainable and controlled deliveries of drugs with controllable toxicities are expected to address these hurdles. Chitosan is the second most abundant natural polysaccharide, which has excellent biocompatibility and notable antitumor activity. Its biodegradability, biocompatibility, biodistribution, nontoxicity and immunogenicity free have made chitosan become a widely used polymer in the pharmacology, especially in oncotherapy. Here, we make a brief review of the main achievements in chitosan and its derivatives in pharmacology with a special focus on their agents delivery applications, immunomodulation, signal pathway modulation and antitumor activity to highlight their role in cancer treatment. Despite a large number of successful studies, the commercialization of chitosan copolymers is still a big challenge. The further development of polymerization technology may satisfy the unmet medical needs.

show abstract

Section: Introductionmentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The previous reports demonstrated that ethanol extracts, coumarins and polysaccharides from SD root and juice of SD had the antiproliferative activity 4 , 40 – 42 . The current study confirmed that VOA and VOR also had significant antiproliferative effect on cancer cell lines of HeLa and HCT-8.…”

Section: Discussionmentioning

confidence: 98%

Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata

Zhou

Mao

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The dried root of Saposhnikovia divaricata (Turcz.) Schischk. is popular as a good medicinal material, however the abundant aerial part is often discarded, which caused the waste of resources. In order to exploit resources, the essential oils of the plant aerial part and root were extracted, separately called as VOA and VOR, their chemicals were identified. The tumor necrosis factor-α, interleukin-6, nitric oxide and interleukin-1β were detected to evaluate the oils anti-inflammatory activities. Then, the oils free radical scavenging rates were measured with DPPH, ABTS and hydroxyl free radical. The oils antitumor activities were evaluated with HeLa and HCT-8 cancer cell lines. The results showed the concentrations of VOA and VOR were separately 0.261% and 0.475%. Seventeen components of VOA were identified, accounting for 80.48% of VOA, including phytol, spathulenol, phytone, 4(15),5,10(14)-Germacratrien-1-ol, neophytadiene, etc. Seven components of VOR were determined, representing 90.73% of VOR, consisted of panaxynol, β-bisabolene, etc. VOA and VOR significantly inhibited the secretion of nitric oxide, interleukin-1β, interleukin‐6 and tumor necrosis factor-α, effectively scavenged the DPPH, ABTS and hydroxyl free radicals, and showed significant antiproliferative activity against HeLa and HCT-8. The two oils presented important biological activity, which provided a hopeful utilized basis, and helped to reduce the waste of the aerial non-medicinal resources of S. divaricata.

show abstract

“…S. divaricata издавна применяется в восточной медицине в качестве эффективного противовоспалительного средства для лечения ревматизма, артралгии, генерализованных и головных болей, при простудных заболеваниях, инсультах, аллергических ринитах, лихорадке, в качестве анальгезирующего, противопаркинсонического средства (Urbagarova, 2019). Экспериментальные исследования показали, что полисахариды, полученные из S. divaricata, могут подавлять рак молочной железы (Ding et al, 2020). Вид является перспективным для введения в отечественную медицинскую практику.…”

Section: Introductionunclassified

Ontogenetic features of <I>Saposhnikovia divaricate</I> (Turcz.) Schischk. introduced into the environments of the Cis-Baikal Region

Khudonogova,

Polovinkina

2024

Trudy po prikladnoy botanike, genetike i selektsii

View full text Add to dashboard Cite

Background. Saposhnikovia (Saposhnikovia Schischk.) is a monotypic genus occurring in the south of Eastern Siberia, the Far East, Mongolia, Manchuria, and Korea. Saposhnikovia divaricata (Turcz.) Schischk. grows in Baikal Siberia and Transbaikalia, but does not occur in the Cis-Baikal Region. Roots, grass and fruits of S. divaricata are used in Oriental medicine as an anti-inflammatory and antipyretic agent. The species is promising for introduction into domestic medical practice. Currently, its area of distribution is rapidly shrinking due to the uncontrolled collection of roots for medicinal purposes. Plant introduction studies can solve the problem of sustainable utilization and conservation of the species.Materials and methods. Ontogenetic features of S. divaricata were studied in the experimental field of Irkutsk State Agrarian University for three years. The age composition of the species was analyzed according to T. A. Rabotnov’s methodology, taking into account the publications by L. B. Zaugolnova with coauthors and E. L. Nukhimovsky.Results and conclusions. S. divaricata is an aboveground two-seeded semi-deciduous plant; its seed germination rate is 87– 90% in the laboratory, and 85–88% in the field. Its plants in the first year of their life pass through the stages of the pregenerative period and proceed into the winter season in a virginal state. About 6% of the plants enter the generative state in the second year of life, and all the rest do it in the third year. The highest root weight was recorded in virginal plants in their second year of life (12.48 g). S. divaricata is a species of mediocre prospects for introduction into the environments of the Cis-Baikal Region.

show abstract

Polysaccharides Derived from Saposhnikovia divaricata May Suppress Breast Cancer Through Activating Macrophages

Cited by 11 publications

References 38 publications

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata

Ontogenetic features of <I>Saposhnikovia divaricate</I> (Turcz.) Schischk. introduced into the environments of the Cis-Baikal Region

Contact Info

Product

Resources

About