Polysaccharides from Aconitum carmichaelii leaves: Structure, immunomodulatory and anti-inflammatory activities

Fu, Yuping; Li, Cen-Yu; Xi-Peng,; Zou, Yuanfeng; Rise, Frode; Paulsen, Berit Smestad; Wangensteen, Helle; Inngjerdingen, Kari Tvete

doi:10.1016/j.carbpol.2022.119655

Cited by 44 publications

(42 citation statements)

References 57 publications

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“…To date, the presence of pectic polysaccharides with a branched RGÀ I core and HG domains have rarely been reported in Aconitum plants, except for pectins found in A. carmichaelii leaves in our previous study. [35] The present study is the first to show the presence of pectins in the roots of A. septentrionale.…”

Section: Extraction and Primary Structural Characterization Of Polysa...mentioning

confidence: 49%

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Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots

Malterud

Hamre

et al. 2023

Chemistry & Biodiversity

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Aconitum septentrionale is known to contain toxic diterpene alkaloids, while other bioactive compounds in the plant remain unclear. The aim of this study was to explore the phenolic compounds and polysaccharides from the water extract of A. septentrionale roots. Fifteen phenolic compounds were isolated and identified by NMR and MS, including fourteen known and one new dianthramide glucoside (2‐[[2‐(β‐D‐glucopyranosyloxy)‐5‐hydroxybenzoyl]amino]‐4,5‐dihydroxybenzoic acid methyl ester, 14). One neutral (complex of glucans with minor amounts of mannans) and two acidic polysaccharide fractions (complexes of pectic polysaccharides and glucans) were also obtained. Hydroxytyrosol (1), hydroxytyrosol‐1‐O‐β‐glucoside (2) and bracteanolide A (7) inhibited the release of nitric oxide by dendritic cells. Magnoflorine (8) and 2‐[[2‐(β‐D‐glucopyranosyloxy)‐5‐hydroxybenzoyl]amino]‐5‐hydroxybenzoic acid methyl ester (12) inhibited 15‐lipoxygenase, and bracteanolide A (7) was a moderate inhibitor of xanthine oxidase. This study is the first to describe the diversity of phenolics and polysaccharides from A. septentrionale and their anti‐inflammatory and anti‐oxidant activities.

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Section: Extraction and Primary Structural Characterization Of Polysa...mentioning

confidence: 49%

“…Monosaccharide composition of the isolated polysaccharide fractions was determined by methanolysis and GC according to a previous study with minor modification as earlier described [35] . Briefly, samples were subjected to acid methanolysis with HCl (3 M) in water‐free methanol (24 h, 80 °C).…”

Section: Methodsmentioning

confidence: 99%

Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots

Malterud

Hamre

et al. 2023

Chemistry & Biodiversity

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“…Polysaccharides from Hizophora mucronate leaves showed a 7.67% extraction yield when being processed using an HWE system at a solid‐to‐liquid ratio of 1/50 (w/v) and a temperature of 90 °C for 3 h 28 . Hot‐water extraction was applied to extract polysaccharides from Aconitum carmichaelii leaves, which showed a 4.2% extraction yield when the extraction was carried out at a solid‐to‐liquid ratio of 1:20 (w/v) and a temperature of above 90 °C (under reflux) with a 1 h extraction time twice 29 . Polysaccharides extracted from Tymus quinquecostatus leaves showed an 86% extraction yield when being processed at a solid‐to‐liquid ratio of 1:20 (w/v) and a temperature of 100 °C for 3 h using HWE 30 .…”

Section: Extraction Methods For Polysaccharidesmentioning

confidence: 99%

Recent trends in extraction, purification, and antioxidant activity evaluation of plant leaf‐extract polysaccharides

Ahmad

Chatha

Iqbal

et al. 2022

Biofuels Bioprod Bioref

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This review elaborates on current advances in the extraction, purification, and antioxidant activity of plant leaf-extract polysaccharides. Polysaccharides are widely used as important ingredients in the food, pharmaceutical, and cosmetic industries. Researchers have been investigating useful sources of natural polysaccharides and developing green and feasible extraction procedures for polysaccharides. This review examines different methods for extracting polysaccharides from leaves, and discusses their advantages and limitations. Purification techniques for plant leaf-based polysaccharides were also highlighted, together with their antioxidant effects. Among different extraction methods, pressurizedliquid extraction and enzyme-assisted extraction are considered to be better for large-scale extraction of polysaccharides from plant leaves. This review could contribute to the design of leaf waste processes at a commercial level for the sustainable recovery of polysaccharides.

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“…The activities of polysaccharides can vary widely, even among those from the same plant, demonstrating a direct relationship between polysaccharide structure and their biological activity [154]. Given the complex structures and various types of polysaccharides, their separation and purification, as well as structure determination, can be very difficult [155], and the characteristics and structures of most reported active polysaccharides are unknown. Therefore, effective new technologies to analyze the relationship between polysaccharide structure and their therapeutic effects, as well as their mechanisms of action in CRC, warrant further exploration.…”

Section: Perspectivementioning

confidence: 99%

Polysaccharides from Chinese herbs as natural weapons against colorectal cancer

et al. 2023

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Colorectal cancer (CRC) ranks third and second among the most widespread cancers worldwide and the most common causes of human death due to cancer, respectively. Further, for unknown reasons, numbers of young patients diagnosed with colon cancer has increased. Polysaccharides are important functional phytochemicals reported to have anti-CRC effects. Moreover, CRC development and progression is closely related to the gut microbiome. Although approaches for treating CRC have been the subject of some review papers, research into traditional Chinese medicine (TCM) treatments for CRC and the underlying mechanisms involving polysaccharides have not been reviewed. Here, we reviewed the mechanisms underlying treatment of CRC using TCM polysaccharides, based on the etiology of CRC, and common treatment methods applied. The relationship between intestinal microbes and CRC, the mechanism by which TCM polysaccharides induce CRC cell apoptosis, and how TCM polysaccharides promote immune responses are discussed, as well as TCM polysaccharide use in combination with chemotherapy. TCM polysaccharides provide options for CRC treatment, due to their advantages of having multiple targets, eliciting modest adverse reactions, and wide range of available sources.

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Polysaccharides from Aconitum carmichaelii leaves: Structure, immunomodulatory and anti-inflammatory activities

Cited by 44 publications

References 57 publications

Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots

Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots

Recent trends in extraction, purification, and antioxidant activity evaluation of plant leaf‐extract polysaccharides

Polysaccharides from Chinese herbs as natural weapons against colorectal cancer

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