Polysaccharides from apple pomace exhibit anti-fatigue activity through increasing glycogen content

Li, Chunguang; Zhu, Xiaodong; Zhang, Jingxia; Xu, Tingting; Zhang, Hong; Zheng, Zhiping; Kumar, Ramasamy Rajesh

doi:10.1007/s13197-022-05613-y

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…In an experiment involving the forced swimming of mice, it was shown that LBP1-decorated selenium nanoparticles (LBP1-SeNPs) were able to mitigate fatigue by increasing the reserve of glycogen in the liver and muscles [ 79 ]. This result was consistent with most other findings [ 14 , 17 , 70 ]. Importantly, adenosine 5‘- monophosphate-activated protein kinase (AMPK) is a master regulator that senses the energy state, maintains glucose homeostasis, and mediates beneficial cellular adaptations in many vital tissues and organs [ 83 ].…”

Section: Polysaccharides Ameliorate Fatiguesupporting

confidence: 94%

“…Polysaccharides have been considered to be a new natural and effective anti-fatigue substance [ 9 ]. Some natural polysaccharides, such as Semen cassiae ( Cassia obtusifolia L.) [ 14 ], Ganoderma lucidum [ 15 ], Lycium barbarum [ 68 ], Cordyceps militaris [ 69 ], and apple pomace [ 70 ], exert beneficial anti-fatigue effects via different pathways ( Figure 1 ). The monosaccharide composition and the anti-fatigue mechanisms of natural polysaccharides are summarized in Table 1 .…”

Section: Polysaccharides Ameliorate Fatiguementioning

confidence: 99%

“…Gut microbiota plays an irreplaceable role in the areas of fatigue and fatigue prevention. On the other hand, numerous studies have proven that natural polysaccharides relieve exercise-induced fatigue by mediating multiple mechanisms [ 68 , 69 , 70 ], but the question remains regarding whether or not they regulate the community structure and function of host microorganism. The complex interactions occurring between polysaccharides, hosts, and different microorganisms are progressively being deciphered.…”

Section: Polysaccharides Ameliorate Fatigue Via the Gut-muscle Axismentioning

confidence: 99%

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Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Zhou,

Chu,

Luo

et al. 2023

Foods

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Due to today’s fast-paced lifestyle, most people are in a state of sub-health and face “unexplained fatigue”, which can seriously affect their health, work efficiency, and quality of life. Fatigue is also a common symptom of several serious diseases such as Parkinson’s, Alzheimer’s, cancer, etc. However, the contributing mechanisms are not clear, and there are currently no official recommendations for the treatment of fatigue. Some dietary polysaccharides are often used as health care supplements; these have been reported to have specific anti-fatigue effects, with minor side effects and rich pharmacological activities. Dietary polysaccharides can be activated during food processing or during gastrointestinal transit, exerting unique effects. This review aims to comprehensively summarize and evaluate the latest advances in the biological processes of exercise-induced fatigue, to understand dietary polysaccharides and their possible molecular mechanisms in alleviating exercise-induced fatigue, and to systematically elaborate the roles of gut microbiota and the gut-muscle axis in this process. From the perspective of the gut-muscle axis, investigating the relationship between polysaccharides and fatigue will enhance our understanding of fatigue and may lead to a significant breakthrough regarding the molecular mechanism of fatigue. This paper will provide new perspectives for further research into the use of polysaccharides in food science and food nutrition, which could help develop potential anti-fatigue agents and open up novel therapies for sub-health conditions.

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