Polysaccharides from fermented coix seed modulates circulating nitrogen and immune function by altering gut microbiota

Wang, Hui; Yin, Heng; Zhong, Yuan; Hu, Jielun; Xia, Shengkun; Wang, Zixuan; Nie, Shaoping; Xie, Mingyong

doi:10.1016/j.crfs.2022.10.007

Cited by 11 publications

(7 citation statements)

References 53 publications

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“…Cardiotoxicity is one of its main side effects, which can be manifested as irreversible dosedependent cardiomyopathy and CHD, so a heart failure model was prepared using this side effect. TNF-α is an inflammatory factor that plays an important role in promoting myocardial remodeling and inhibiting myocardial contraction, as well as in increasing endothelial and myocardial apoptosis, and there is abundant evidence that inhibition or reduction has a protective effect in heart failure models (Lee et al, 2019;Reina-Couto et al, 2021;Szabo et al, 2021;Zhong et al, 2022). BNP is a marker of cardiac insufficiency, and many studies have shown that plasma BNP levels are significantly elevated in heart failure patients, which can be used for the diagnosis of heart failure (Ichiki et al, 2013;McDonald et al, 2018;Rørth et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Coix seed has multiple pharmacological effects such as anti-tumor, improving body immunity, hypoglycemia, anti-inflammatory and analgesic, and regulating lipid metabolism, and its important pharmacological activities in the treatment of cervical cancer, lung cancer, and gastrointestinal tract tumors have been confirmed in clinical practice (Ni et al, 2021;Zhou et al, 2021;Sui and Xu, 2022;. In a related experimental study, Coix seed was found to improve Th1/ Th2 cytokines in mice to restore immune homeostasis after administration (Wang H. et al, 2022). Fuzi is commonly used in clinical practice for the treatment of heart diseases such as heart failure, and its main chemical constituents are alkaloids with cardiac analgesic, anti-myocardial ischemic, antiarrhythmic, and improving the energy metabolism of cardiomyocytes (Zhang et al, 2017;Yan et al, 2020;Chen et al, 2022;Tai et al, 2022).…”

Section: Introductionmentioning

confidence: 98%

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Pharmacological effects and mechanisms of YiYiFuZi powder in chronic heart disease revealed by metabolomics and network pharmacology

Wang

et al. 2023

Front. Mol. Biosci.

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Introduction: YiYiFuZi powder (YYFZ) is a classical formula in Chinese medicine, which is commonly used clinically for the treatment of Chronic Heart Disease (CHD), but it’s pharmacological effects and mechanism of action are currently unclear.Methods: An adriamycin-induced CHD model rat was established to evaluate the pharmacological effects of YYFZ on CHD by the results of inflammatory factor level, histopathology and echocardiography. Metabolomic studies were performed on rat plasma using UPLC-Q-TOF/MS to screen biomarkers and enrich metabolic pathways; network pharmacology analysis was also performed to obtain the potential targets and pathways of YYFZ for the treatment of CHD.Results: The results showed that YYFZ significantly reduced the levels of TNF-α and BNP in the serum of rats, alleviated the disorder of cardiomyocyte arrangement and inflammatory cell infiltration, and improved the cardiac function of rats with CHD. The metabolomic analysis identified a total of 19 metabolites, related to amino acid metabolism, fatty acid metabolism, and other metabolic pathways. Network pharmacology showed that YYFZ acts through PI3K/Akt signaling pathway, MAPK signaling pathway and Ras signaling pathway.Discussion: YYFZ treatment of CHD modulates blood metabolic pattern and several protein phosphorylation cascades but importance specific changes for therapeutic effect require further studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Pharmacological effects and mechanisms of YiYiFuZi powder in chronic heart disease revealed by metabolomics and network pharmacology

Wang

et al. 2023

Front. Mol. Biosci.

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“…Lp. plantarum NCU137-fermentation of Coix seed was found to significantly increase the splenic index, restore the CD4 + /CD8 + ratio of splenic T lymphocyte subsets, down-regulate TNF- α and IL-6 production, and reduce inflammation, and the effect was better than that of unfermented group ( Wang et al 2022 ). Mixed probiotics ( Lactobacillus acidophilus and Bifidobacterium breve )-mediated fermentation of G. lucidum fruiting bodies increased the proportion of CD4 + T and CD8 + T lymphocytes in mouse spleen and improved T cell transformation ( Li et al, 2021 ).…”

Section: Immunoregulatory Mechanism Of Lactic Acid Bacteria-fermented...mentioning

confidence: 97%

New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines

Zhu

Yu²,

Du³

2022

Front. Microbiol.

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The COVID-19 pandemic has brought more attention to the immune system, the body’s defense against infectious diseases. The immunomodulatory ability of traditional herbal medicine has been confirmed through clinical trial research, and has obvious advantages over prescription drugs due to its high number of potential targets and low toxicity. The active compounds of herbal drugs primarily include polysaccharides, saponins, flavonoids, and phenolics and can be modified to produce new active compounds after lactic acid bacteria (LAB) fermentation. LAB, primary source of probiotics, can produce additional immunomodulatory metabolites such as exopolysaccharides, short-chain fatty acids, and bacteriocins. Moreover, several compounds from herbal medicines can promote the growth and production of LAB-based immune active metabolites. Thus, LAB-mediated fermentation of herbal medicines has become a novel strategy for regulating human immune responses. The current review discusses the immunomodulatory properties and active compounds of LAB fermented herbal drugs, the interaction between LAB and herbal medicines, and changes in immunoregulatory components that occur during fermentation. This study also discusses the mechanisms by which LAB-fermented herbal medicines regulate the immune response, including activation of the innate or adaptive immune system and the maintenance of intestinal immune homeostasis.

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“…Coix seed is a commonly used clinical drug with activities such as anti-tumor (Figure 3 ), immune regulation[ 24 , 25 ], hypoglycemic[ 26 , 27 ], anti-inflammatory[ 28 , 29 ], improving intestinal microbiota[ 17 , 30 ], lowering blood lipids[ 31 , 32 ], and promoting angiogenesis[ 33 ]. After KEGG enrichment analysis, we mainly discuss the pharmacological effects of Coix seed on anti-tumor effects (Table 2 ).…”

Section: The Anti-tumor Effect Of Coix Seedmentioning

confidence: 99%

Anti-tumor effect of coix seed based on the theory of medicinal and food homology

Meng,

Yuan,

et al. 2023

World J Clin Oncol

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Coix seed is a dry and mature seed of Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf in the Gramineae family. Coix seed has a sweet, light taste, and a cool nature. Coix seed enters the spleen, stomach, and lung meridians. It has the effects of promoting diuresis and dampness, strengthening the spleen to prevent diarrhea, removing arthralgia, expelling pus, and detoxifying and dispersing nodules. It is used for the treatment of edema, athlete's foot, poor urination, spleen deficiency and diarrhea, dampness and obstruction, lung carbuncle, intestinal carbuncle, verruca, and cancer. The medicinal and health value is high, and it has been included in the list of medicinal and food sources in China, which has a large development and application space. This article reviews the current research achievements in the processing methods and anti-tumor activities of Coix seed and provides examples of its clinical application in ancient and modern times, aiming to provide reference for further research on Coix seed and contribute to its clinical application and development. Through the analysis of the traditional Chinese patent medicines, and simple preparations and related health food of Coix seed queried by Yaozhi.com, the source, function, and dosage form of Coix seed were comprehensively analyzed, with a view of providing a reference for the development of Coix seed medicine and food.

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Polysaccharides from fermented coix seed modulates circulating nitrogen and immune function by altering gut microbiota

Cited by 11 publications

References 53 publications

Pharmacological effects and mechanisms of YiYiFuZi powder in chronic heart disease revealed by metabolomics and network pharmacology

Pharmacological effects and mechanisms of YiYiFuZi powder in chronic heart disease revealed by metabolomics and network pharmacology

New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines

Anti-tumor effect of coix seed based on the theory of medicinal and food homology

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