Polysaccharides from Phellinus linteus: A systematic review of their extractions, purifications, structures and functions

Qin, Dandan; Han, Shuai; Liu, Meilin; Guo, Tianyi; Hu, Zuomin; Zhou, Yaping; Luo, Feijun

doi:10.1016/j.ijbiomac.2023.123163

Cited by 26 publications

(7 citation statements)

References 120 publications

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“…Furthermore, polysaccharides with low molecular weights can be more easily absorbed and therefore be more readily applied for therapeutic applications ( 41 ). However, the extraction process, molecular weight, monosaccharide compositions and chemical structure of polysaccharides can all have effects on their subsequent biological activities ( 14 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, P. linteus is a well-known medicinal mushroom that contains a number of bioactive compounds, including polyphenols, terpenoids, furans and polysaccharides. Previous studies have reported that extracts from fruiting bodies or cultured mycelium can exhibit numerous bioactivities, such as anticancer, anti-inflammation, immunomodulatory, antioxidant and antidiabetic effects ( 14-18 ). Therefore, Smilax corbularia and Phellinus linteus were the plant and fungi of interest in this study.…”

Section: Introductionmentioning

confidence: 99%

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In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

Syukriya,

Bankeeree,

Prasongsuk

et al. 2023

Biomed Rep

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Treatment with extracts from whole herbs has been reported to synergistically enhance the anticancer activities of therapeutic agents in recent studies. The present study evaluated the antioxidant and anticancer activities of Smilax corbularia Kunth ( S. corbularia ) and Phellinus linteus ( P. linteus ) crude extracts individually and in combination. S. corbularia was extracted using ethanol, whereas P. linteus was extracted using hot water. Both crude extracts underwent physiochemical characterization. Subsequently, the possible antioxidant activities of both crude extracts, individually and in combination, were evaluated using 2,2-Diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assays. Their effects on breast cancer cell cytotoxicity, proliferation and apoptosis were then assessed. The crude S. corbularia extract obtained was found to have a high level of total phenolic content, whilst the crude P. linteus extract had high levels of total polysaccharide content. The total phenolic content and total polysaccharide content results of the combinations depended on the respective ratios of the individual extracts. S. corbularia alone and combination 3 (which contained 75% S. corbularia : 25% P. linteus ) demonstrated the greatest radical scavenging activity, followed by combination 1 (50% S. corbularia : 50% P. linteus ), combination 2 (25% S. corbularia : 75% P. linteus ) and P. linteus . The toxicity results of the extract samples on the cancer cells corresponded with their antioxidant activity. In particular, certain combinations demonstrated clearer inhibitory effects on cell proliferation against three types of breast cancer cells compared with those exerted by the two individual extracts. However, induction of apoptosis was limited, with the degree of apoptosis observed to be #x003C;5%. These findings suggested that treatment with combinations of these two extracts could confer enhanced antioxidant and antiproliferative effects on breast cancer cells. Therefore, the potential of these two extracts in combination as anticancer agents warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

Syukriya,

Bankeeree,

Prasongsuk

et al. 2023

Biomed Rep

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“…The structure-activity relationship and mechanism of action of polysaccharides are important research topics in glycobiology. The bioactivity of polysaccharides is closely related to their structure and conformation [ 39 ]. Carbohydrate-hydrolyzing enzymes are essential for the development of drugs to delay glucose absorption for the treatment of T2DM to delay glucose absorption [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of Phellinus igniarius fermentation mycelia contributions of different solvent extractions and their inhibitory effect on α-amylase

Dong,

Wang,

Gan

et al. 2024

Heliyon

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“…The advanced structure of polysaccharides also has a great influence on their biological activities [111] .…”

Section: Conformation Propertiesmentioning

confidence: 99%

Prospects of sea buckthorn ( Hippophae rhamnoides L.) polysaccharides: preparation, structural characterization, and bioactivities diversity

Shi,

Wu,

Han

et al. 2024

Food Science and Human Wellness

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Sea buckthorn (Hippophae rhamnoides L.) is a natural homologous substance of medicine and food. Polysaccharide, as one of its primary active components, has very superior biological activity and can be used as a dietary supplement for functional foods, with good commercial prospects. Although initial progress has been made in the study of sea buckthorn polysaccharides, related studies have been fragmented and lacked systematic and generalization. This manuscript presents a critical analysis and systematic summary of the extraction and purification methods, structural characterization and physicochemical properties, biological activity and potential mechanisms, and structure-activity relationships of sea buckthorn polysaccharides. Accumulating evidence has indicated that sea buckthorn polysaccharides, which were widely prepared by water extraction and column chromatography purifications, exhibited exhibit superior biological activities in vitro and in vivo, including antioxidant, immunomodulatory, anti-inflammatory, hepatorenal protective, antibacterial, antiviral, and prebiotic activities. After analysis, it was concluded that there is a correlation between the relevant activities of sea buckthorn polysaccharides and that the structure of sea buckthorn polysaccharides has a great influence on their biological activity. We reviewed the challenges and limitations of sea buckthorn polysaccharides, summarized the critical aspects, and provided suggestions for potential breakthroughs in the research and application of sea buckthorn polysaccharide.

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Polysaccharides from Phellinus linteus: A systematic review of their extractions, purifications, structures and functions

Cited by 26 publications

References 120 publications

In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

Antioxidant activity of Phellinus igniarius fermentation mycelia contributions of different solvent extractions and their inhibitory effect on α-amylase

Prospects of sea buckthorn ( Hippophae rhamnoides L.) polysaccharides: preparation, structural characterization, and bioactivities diversity

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