Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo

Pillai, Thulasi G.; Nair, Cherupally Krishnan Krishnan; Janardhanan, K. K.

doi:10.1016/j.etap.2008.02.004

Cited by 49 publications

(24 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Polysaccharides were isolated by the method proposed by Pillai [21] with some modifications. Ten grams of fungal material was extracted three times with 200 mL of hot water (85°C) for 5 h. Water extracts were filtered, combined and concentrated to 100 mL.…”

Section: Extractionmentioning

confidence: 99%

Evaluation of polysaccharides content in fruit bodies and their antimicrobial activity of four Ganoderma lucidum (W Curt.: Fr.) P. Karst. strains cultivated on different wood type substrates

et al. 2012

View full text Add to dashboard Cite

Quantitative determination of polysaccharides in Ganoderma lucidum fruit bodies from different sawdust cultivation substrates and their antibacterial activity was done. Thirty six samples were analyzed. Four strains of Ganoderma lucidum (GL01, GL02, GL03 and GL04) were cultivated on the growth substrates of three different sawdust types: birch (Bo), maple (Kl) or alder (Ol) amended with wheat bran in three different concentrations: 10, 20 and 30% (w/w). Even though the richest in polysaccharides was GL01 strain, the highest yields of the polysaccharides were determined in GL04Kl3 sample and was 112.82 mg/g of dry weight. The antibacterial activity of polysaccharides was determined in vitro using micro-dilution broth method. The panel of eight reference bacterial strains was used. All the polysaccharide samples tested showed the broad spectrum and the moderate antibacterial activity. Micrococcus luteus ATCC 10240 strain was the most sensitive with MIC (minimal inhibitory concentration) = 0.63 − 1.25 mg/mL

show abstract

Section: Extractionmentioning

confidence: 99%

Evaluation of polysaccharides content in fruit bodies and their antimicrobial activity of four Ganoderma lucidum (W Curt.: Fr.) P. Karst. strains cultivated on different wood type substrates

et al. 2012

View full text Add to dashboard Cite

show abstract

“…G. lucidum has been used as a remedy for a wide range of ailments and chronic diseases, such as migraine, hypertension, arthritis, bronchitis, asthma, anorexia, gastritis, haemorrhoids, diabetes, hypercholesterolaemia, nephritis, dysmenorrhoea, constipation, lupus erythematosis, hepatitis, and cardiovascular problems (Jong and Birmingham 1992;Shiao et al 1994). Previous investigations in our laboratory showed that G. lucidum occurring in South India possessed significant antioxidant, antitumor, anti-inflammatory, antinociceptive, nephroprotective and radioprotective properties (Jones and Janardhanan 2000;Sheena et al 2003a, b;Lakshmi et al 2003;Pillai et al 2008). G. lucidum is also reported to possess significant antioxidant and DNA protective effects (Kim and Kim 1999;Lee et al 2001).…”

Section: Introductionmentioning

confidence: 96%

Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat

2009

View full text Add to dashboard Cite

Aging is associated with increased oxidative damage at multiple cellular levels, decline in cellular energy production and enhanced free radical status. The effect of the medicinal mushroom, Ganoderma lucidum on the activities of tricarboxylic acid (Krebs) cycle enzymes and mitochondrial complexes I-IV of the electron transport chain in aged rats were investigated. The activity of Krebs cycle enzymes, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase as well as mitochondrial complexes I, II, III, and IV were determined in heart of aged male Wistar rats orally administrated with 70% ethanolic extract (50 and 250 mg/kg) of G. lucidum. DL-alpha-lipoic acid (100 mg/kg) was taken as the positive control. Administration of the G. lucidum, once daily for 15 days, was significantly (P < 0.05) effective to enhance the Krebs cycle dehydrogenases, and mitochondrial electron transport chain complex IV activities in aged rats. The profound activity of the extract can be correlated to the significant antioxidant property of G. lucidum. The results of the study revealed that G. lucidum is effective to ameliorate the age associated decline of cellular energy status.

show abstract

“…Eo et al purified two protein-bound GPLs (a neutral one and a acidic one) from the hot-water extract of carpophores of Ganoderma lucidum by DEAE-cellulose and Sepharose CL-4B chromatography [7,8]. Pillai et al isolated a neutral GPL by DEAE-cellulose chromatography from the fruiting bodies of Ganoderma lucidum [9].…”

Section: Introductionmentioning

confidence: 99%

Purification and structural characterization of a new water-soluble neutral polysaccharide GLP-F1-1 from Ganoderma lucidum

Huang

et al. 2011

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo

Cited by 49 publications

References 22 publications

Evaluation of polysaccharides content in fruit bodies and their antimicrobial activity of four Ganoderma lucidum (W Curt.: Fr.) P. Karst. strains cultivated on different wood type substrates

Evaluation of polysaccharides content in fruit bodies and their antimicrobial activity of four Ganoderma lucidum (W Curt.: Fr.) P. Karst. strains cultivated on different wood type substrates

Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat

Purification and structural characterization of a new water-soluble neutral polysaccharide GLP-F1-1 from Ganoderma lucidum

Contact Info

Product

Resources

About