Polysialylated Neural Cell Adhesion Molecule Supports Regeneration of Neurons in the Nucleus Ambiguus After Unilateral Recurrent Laryngeal Nerve Avulsion in Adult Rats

The intact parasympathetic nerve promotes submandibular gland regeneration through ductal cell proliferation

“…PSA-NCAM is a predictor of neural cell repair after peripheral nerve injury and modulates liver regeneration. 19,21 Immunohistochemistry was used to investigate the expression of NCAM and polySTs during gland regeneration. Under normal conditions, NCAM protein is expressed at a very low and stable level.…”

“…20 It has been reported that PSA-NCAM can be used as a predictor of neural cell repair after unilateral recurrent laryngeal nerve injury. 21 Fukuda et al reported that NCAM was generally expressed in human submandibular salivary gland tumour cell line (HSG). 22 However, the roles of PSA-NCAM in mediating the regeneration of salivary gland after cutting off the parasympathetic nerve are unknown.…”

Correlation between Sialylation Status and Cell Susceptibility to Amyloid Toxicity

“…During development, PolySia-NCAM exhibits a high expression, especially in the nervous system, where it promotes dynamic cell interactions involved in neurogenesis, such as cell migration [ 28 , 40 , 41 , 42 , 43 ], axon/dendrite growth and remodeling [ 40 , 41 , 42 , 43 , 44 ] and synaptic reorganization [ 28 , 40 , 41 , 42 , 43 , 44 ]. Regardless, its expression is evident, although more restricted, in the adult nervous system, where PolySia-NCAM contributes to various forms of neuronal [ 40 , 41 , 42 , 43 , 44 , 45 , 46 ] and glial [ 41 , 42 , 43 ] plasticity, and neural regeneration [ 41 , 42 , 44 , 47 ].…”