Polysomnographic abnormalities in patients with vascular cognitive impairment-no dementia

Jiang, Bo; Cheng-yun, Ding; Yao, Guo-En; Yao, Chia-Yu; Zhang, Yunyan; Ge, Junling; Qiu, Enchao; Elia, Maurizio; Ferri, Raffaele

doi:10.1016/j.sleep.2013.07.003

Cited by 17 publications

(22 citation statements)

References 29 publications

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“…Three qualified studies reported correlations between PLMS severity and CVA [29][30][31] Among these 3 studies, those by Coelho et al [29] and Jiang et al [31] included well-randomized control and experimental groups with statistically moderate sample sizes, and Benbir et al [30] study had a modified NOS score of 7, indicating a high quality nonrandomized study. With regards to the significant heterogeneity among these 3 studies, the potential causes included: (a) different patient populations (geographic areas and ethnicities); and (b) different study designs and qualities.…”

Section: Discussionmentioning

confidence: 99%

“…With regards to the significant heterogeneity among these 3 studies, the potential causes included: (a) different patient populations (geographic areas and ethnicities); and (b) different study designs and qualities. The study by Coelho et al [29] was conducted in Canada, the study by Benbir et al [30] was conducted in Turkey, and the study by Jiang et al [31] was conducted in China. Therefore, even though there were no clear descriptions in any of the 3 studies, there may have been racial differences among them.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, even though there were no clear descriptions in any of the 3 studies, there may have been racial differences among them. In addition, the experimental groups in the studies by Benbir et al [30] and Jiang et al [31] were comprised of hospitalized patients with acute ischemic stroke, while the study by Coelho et al [29] included patients attending a hospital sleep laboratory with a self-reported stroke history. The modified NOS score of Jiang et al [31] study was 8, which was better than the studies by Coelho et al [29] and Benbir et al [30] (both had an NOS score of 7).…”

Section: Discussionmentioning

confidence: 99%

“…Of these 8 eligible articles, 3 provided differences in PLM index in patients with CVA and those in controls (patients with CVA = 179, mean age = 63.5, mean female proportion = 32.9%; controls without CVA = 122, mean age = 63.5 years, mean female proportion = 30.9%) [29][30][31]. The other 5 articles provided the comorbidity data of CVA in patients with PLMS (patients with PLMS = 9,823, mean age = 65.2, mean female proportion = 28.1%; controls without PLMS = 9,416, mean age = 56.8, mean female proportion = 39.4%) [7-9, 32, 33].…”

Section: Study Selectionmentioning

confidence: 99%

“…Index between the Patients with CVA and Controls without CVA Among the 3 eligible articles comparing differences in PLM index between the patients with CVA and controls without CVA [29][30][31], the meta-analysis results revealed a significantly higher PLM index in the patients with CVA than in the controls without CVA (Hedges' g = 0.860, 95% CI 0.359-1.361, p = 0.001; difference in means: 4.435, 95% CI 0.836-8.034, p = 0.016; Fig. 2a) with significant heterogeneity (Q value = 14.80, df = 3, p = 0.002; I 2 = 79.73%), but no publication bias was found by visual examination of the funnel plot (Fig.…”

Section: Meta-analysis Investigating Differences In the Plmmentioning

confidence: 99%

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Cerebrovascular Accident Risk in a Population with Periodic Limb Movements of Sleep: A Preliminary Meta-Analysis

Lin

Zeng

Chen³

et al. 2018

Cerebrovasc Dis

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Background and Purpose: Periodic limb movements of sleep (PLMS) are usually comorbid with hypertension, tachycardia, and coronary arterial diseases, which are also risk factors for cerebrovascular accidents (CVA). However, evidence about the relationship between CVA and PLMS is still weak. The aim of this study was to investigate (1) the prevalence of CVA in patients with PLMS, and (2) the severity of PLMS in patients with or without CVA through a meta-analysis. Methods: The electronic databases of PubMed, Embase, ScienceDirect, ClinicalKey, Cochrane Library, ProQuest, Web of Science, and ClinicalTrials.gov were searched. The inclusion criteria were (1) articles investigating comorbidity between PLMS and CVA, and (2) clinical trials in humans. Results: This meta-analysis included (1) 9,823 patients with PLMS and 9,416 controls from 5 studies to analyze the prevalence of CVA in PLMS, and (2) 158 patients with PLMS with CVA and 88 PLMS controls without CVA from 3 studies to analyze the severity of PLMS with and without CVA. The results showed (1) significantly higher comorbidity rates of CVA in the patients with PLMS than in the controls without PLMS (OR 1.267, p = 0.019), and (2) higher PLM index in the patients with CVA than in the controls (Hedges’ g = 0.860, p = 0.001; means difference: 4.435, p = 0.016). Conclusions: The results revealed (1) a worse severity of PLMS in the patients with CVA, and (2) increased prevalence of CVA in the patients with PLMS. Based on our results, the patients had a higher prevalence of CVA within 8 years of a diagnosis of PLMS compared to those without PLMS by about 1.3-fold. Whether (1) patients with PLMS receiving treatment have a similar incidence of stroke to those without PLMS, and (2) secondary stroke prevention can lower the severity of PLMS or whether those with severe PLMS have a higher risk of stroke is still inconclusive. Future studies investigating the prevalence of CVA in patients with PLMS should use a follow-up period of over 8 years.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Meta-analysis Investigating Differences In the Plmmentioning

confidence: 99%

See 3 more Smart Citations

Cerebrovascular Accident Risk in a Population with Periodic Limb Movements of Sleep: A Preliminary Meta-Analysis

Lin

Zeng

Chen³

et al. 2018

Cerebrovasc Dis

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Study Design and Analysis in Sleep Medicine

DeBari

2017

Sleep Disorders Medicine

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Sleep disturbance in mild cognitive impairment: a systematic review of objective measures

Zhang

et al. 2017

Neurol Sci

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Sleep disturbance frequently occurs in patients with mild cognitive impairment (MCI) and appears to be involved in the cellular and molecular mechanisms of cognitive decline. The aim of this systematic review is to clarify whether patients with MCI demonstrate alterations in certain sleep parameters: total sleep time (TST), sleep efficiency (SE), sleep latency (SL), rapid eye movement latency (REML), percent of rapid eye movement (REM%), arousal index (AI), wake after sleep onset (WASO), slow-wave sleep (SWS), periodic leg movement in sleep (PLMS), and cyclic alternating pattern (CAP) through polysomnography (PSG) and actigraphy. Databases including PubMed, Web of Science, Embase, ScienceDirect, Cochrane, CBM, CNKI, Wanfang Data, and VIP were searched up to January 2016 to collect literature on the correlation between sleep disturbance and MCI as assessed by objective measures. Meta-analysis was conducted using the Review Manager 5.3 software. A total of ten case-control studies involving 225 MCI patients and 235 healthy elders (HE) were deemed eligible and included in our meta-analysis. Every type of sleep disturbance was present in our studies with significant differences in the MCI subtypes. Compared with HE, overall MCI patients as a group expressed more SL and less SE; MCI patients showed less TST and SE and more SL and CAP; patients with amnestic mild cognitive impairment (aMCI) had less AI; patients with non-amnestic mild cognitive impairment (naMCI) had more TST and less AI. Patients with naMCI expressed more AI than those with aMCI. The results indicate that MCI patients might experience more serious sleep disturbance and that different MCI subtypes have different patterns of sleep disturbance.

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Polysomnographic abnormalities in patients with vascular cognitive impairment-no dementia

Cited by 17 publications

References 29 publications

Cerebrovascular Accident Risk in a Population with Periodic Limb Movements of Sleep: A Preliminary Meta-Analysis

Cerebrovascular Accident Risk in a Population with Periodic Limb Movements of Sleep: A Preliminary Meta-Analysis

Study Design and Analysis in Sleep Medicine

Sleep disturbance in mild cognitive impairment: a systematic review of objective measures

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