Polysorbate 80 and polymyxin B inhibit Stenotrophomonas maltophilia biofilm

Malinowski, Adam M.; McClarty, Bryan M.; Robinson, Carolyn A. Jost; Spear, William; Sánchez, María Blanca; Sparkes, Timothy C.; Brooke, Joanna S.

doi:10.1016/j.diagmicrobio.2016.11.008

Cited by 11 publications

(3 citation statements)

References 10 publications

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“…Polysorbate 80 reduced Pseudomonas aeruginosa biofilm formation on medically relevant materials, including contact lenses, at concentrations safe in humans [ 21 ]. More recently, a combination of sub-minimal inhibitory concentration (sub-MIC) polymyxin B and polysorbate 80 inhibited biofilm formation of the opportunistic multiple-drug-resistant pathogen Stenotrophomonas maltophilia [ 22 ]. In addition, an inhibitory effect was demonstrated on plastic, silicone, and dermal tissues on Methicillin-resistant S. aureus (MRSA) biofilm formation, suggesting its effectiveness on tissues and foreign bodies as a washing solution for wounds and/or pretreatment of indwelling catheters [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Diverse Effects of Natural and Synthetic Surfactants on the Inhibition of Staphylococcus aureus Biofilm

et al. 2021

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A major challenge in the biomedical field is the creation of materials and coating strategies that effectively limit the onset of biofilm-associated infections on medical devices. Biosurfactants are well known and appreciated for their antimicrobial/anti-adhesive/anti-biofilm properties, low toxicity, and biocompatibility. In this study, the rhamnolipid produced by Pseudomonas aeruginosa 89 (R89BS) was characterized by HPLC-MS/MS and its ability to modify cell surface hydrophobicity and membrane permeability as well as its antimicrobial, anti-adhesive, and anti-biofilm activity against Staphylococcus aureus were compared to two commonly used surfactants of synthetic origin: Tween® 80 and TritonTM X-100. The R89BS crude extract showed a grade of purity of 91.4% and was composed by 70.6% of mono-rhamnolipids and 20.8% of di-rhamnolipids. The biological activities of R89BS towards S. aureus were higher than those of the two synthetic surfactants. In particular, the anti-adhesive and anti-biofilm properties of R89BS and of its purified mono- and di-congeners were similar. R89BS inhibition of S. aureus adhesion and biofilm formation was ~97% and 85%, respectively, and resulted in an increased inhibition of about 33% after 6 h and of about 39% after 72 h when compared to their chemical counterparts. These results suggest a possible applicability of R89BS as a protective coating agent to limit implant colonization.

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Section: Introductionmentioning

confidence: 99%

Diverse Effects of Natural and Synthetic Surfactants on the Inhibition of Staphylococcus aureus Biofilm

et al. 2021

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“…45,46 Furthermore, polysorbate 80 has also been shown to inhibit biofilms in P. aeruginosa and Escherichia coli. 47,48 Malinowski et al 49 investigated the effects of polymyxin B and polysorbate 80, and it was found to inhibit the growth and biofilm formation of Stenotrophomonas maltophilia. However, the authors were unable to show how PS80-inhibited biofilms.…”

Section: Surfactants and Biofilmsmentioning

confidence: 99%

Surfactants: Role in biofilm management and cellular behaviour

Percival

Mayer

Kirsner

et al. 2019

International Wound Journal

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Appropriate and effective wound cleaning represents an important process that is necessary for preparing the wound for improved wound healing and for helping to dislodge biofilms. Wound cleaning is of paramount importance to wound bed preparation for helping to enhance wound healing. Surfactant applications in wound care may represent an important area in the cleaning continuum. However, understanding of the role and significance of surfactants in wound cleansing, biofilm prevention and control, and enhancing cellular viability and proliferation is currently lacking. Despite this, some recent evidence on poloxamer‐based surfactants where the surfactants are present in high concentration have been shown to have an important role to play in biofilm management; matrix metalloproteinase modulation; reducing inflammation; and enhancing cellular proliferation, behaviour, and viability. Consequently, this review aims to discuss the role, mode of action, and clinical significance of the use of medically accepted surfactants, with a focus on concentrated poloxamer‐based surfactants, to wound healing but, more specifically, the role they may play in biofilm management and effects on cellular repair.

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“…Resistance in S. maltophilia to various antibiotics can lead to numerous problems in controlling hospital-acquired infections and threaten public health. That is why identification of this bacterial species is very useful in therapy management [5]. Therefore, based on foregoing evidence the present study conducted to determine frequency of occurrence of S. maltophilia at different hospitals in shiraz, Iran in order to achieve maximum information regarding to occurrence of S. maltophilia in our area.…”

Section: Introductionmentioning

confidence: 98%

Isolation of Stenotrophomonas maltophilia from Clinical Samples in Some Hospitals in Shiraz, Iran

Zarezadeh¹,

Baserisalehi²,

Shoa³

2020

CEI

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Stenotrophomonas maltophilia is an emerging pathogenic non-fermentative Gram-negative Bacillus species. It has caused many nosocomial infections and can be isolated from various hospital wards and healthcare facilities. Research has shown that most of its strains are inherently resistant to many antibiotics and have multidrug resistance. This research intended to determine its occurrence frequency at some Hospitals in shiraz, Iran. The present study was conducted in six months (from early spring to late summer 2019). Clinical samples (Blood, Urine and cerebrospinal fluid (CSF)) collected from 120 patients afflicted with various infections. The samples were transferred to the Laboratory and subjected to microbiological analysis. Identification of the isolates was carried out by phenotypic methods and Stenotrophomonas maltophilia isolates verified using molecular methods. In total, various bacteria were isolated from 84 clinical samples. The isolates were Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Stenotrophomonas maltophilia, Staphylococcus aureus and Pseudomonas aeruginosa. Stenotrophomonas maltophilia was isolated from 17 (20.2%) positive samples and most of them were isolated from blood samples. Our finding indicated that Stenotrophomonas maltophilia isolated more from blood samples follow by CSF sample. In addition, our finding illustrated that Stenotrophomonas maltophilia can be considered as the common nosocomial agent at hospitals in Shiraz, Iran.

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Polysorbate 80 and polymyxin B inhibit Stenotrophomonas maltophilia biofilm

Cited by 11 publications

References 10 publications

Diverse Effects of Natural and Synthetic Surfactants on the Inhibition of Staphylococcus aureus Biofilm

Diverse Effects of Natural and Synthetic Surfactants on the Inhibition of Staphylococcus aureus Biofilm

Surfactants: Role in biofilm management and cellular behaviour

Isolation of Stenotrophomonas maltophilia from Clinical Samples in Some Hospitals in Shiraz, Iran

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