Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-β1/Smad3 pathways

Yang, Jian-Zheng; Zhang, Kai-Kai; Hsu, Clare; Miao, Lin; Chen, Li-Jian; Liu, Jia-Li; Li, Jia-Hao; Li, Xiu-Wen; Zeng, Jia-Hao; Chen, Long; Li, Ji-Hui; Xie, Xiao-Li; Wang, Qi

doi:10.1016/j.jhazmat.2024.134823

Journal of Hazardous Materials

2024

DOI: 10.1016/j.jhazmat.2024.134823

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Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-β1/Smad3 pathways

Jian-Zheng Yang,

Kai-Kai Zhang,

Clare Hsu

et al.

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2024

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Cited by 2 publications

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Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

Zhang,

Yang,

et al. 2024

ACS Nano

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Exposure to micro-and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, in vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences in animal models compromise the reliability of the conclusions. In addition, current research has predominantly focused on single-time point exposures to MNPs, neglecting comparative analyses of cardiac injury across early and late stages. Moreover, there remains a large gap in understanding the susceptibility to MNPs under pathological conditions. To address these limitations, this study integrated cardiac organoids (COs) and organ-on-achip (OoC) technology to develop the cardiac organoid-on-achip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based on COoC, we conducted a dynamic observation of the cardiac damage caused by short-and long-term exposure to polystyrene nanoplastics (PS-NPs). Oxidative stress, inflammation, disruption of calcium ion homeostasis, and mitochondrial dysfunction were confirmed as the potential mechanisms of PS-NP-induced cardiotoxicity and the crucial events in the early stages, while cardiac fibrosis emerged as a prominent feature in late stages. Notably, low-dose exposure exacerbated myocardial infarction symptoms under pathological states, despite no significant cardiotoxicity shown in healthy models. In conclusion, these findings further deepened our understanding of PS-NP-induced cardiotoxic effects and introduced a promising in vitro platform for assessing cardiotoxicity.

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Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

Zhang,

Yang,

et al. 2024

ACS Nano

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Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Gou,

Deng,

Tang

et al. 2024

Environ. Sci.: Nano

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Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-β1/Smad3 pathways

Cited by 2 publications

References 35 publications

Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

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