Polyurethane-Based Nanocomposites for Regenerative Therapies of Cancer Skin Surgery with Low Inflammatory Potential to Healthy Fibroblasts and Keratinocytes In Vitro

Mrówka, Maciej; Lenża-Czempik, Joanna; Dawicka, Anahit; Skonieczna, Magdalena

doi:10.1021/acsomega.3c01663

Cited by 3 publications

References 62 publications

(113 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Surface Engineering of Ti13zr13nb Biomaterial Alloy with Gold Via Laser Melting for Enhanced Biocompatibility and Functional Performance

Bialas,

Kunwar,

Taratuta

et al. 2024

Preprint

View full text Add to dashboard Cite

Surface Engineering of Ti13zr13nb Biomaterial Alloy with Gold Via Laser Melting for Enhanced Biocompatibility and Functional Performance

Bialas,

Kunwar,

Taratuta

et al. 2024

Preprint

View full text Add to dashboard Cite

Quality by Design Approach for the Formulation and Evaluation of Stem Cells Derived Rosmarinic Acid-Loaded Nanofibers as an Anti-Wrinkle Patch: In Vitro and In Vivo Characterizations

Abdelmonem,

Bakr,

Badawy

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Background/Objectives: Skin wrinkles result from a myriad of multifaceted processes involving intrinsic and extrinsic aging. To combat this effect, plant stem cells offer a renewable and eco-friendly source for various industries, including cosmeceuticals. Salvia miltiorrhiza (SM), which contains the bioactive compound Rosmarinic acid (RA) and has been proposed for its anti-wrinkle effect. Methods: In the present study, calli from SM were cultured and Quality by Design (QbD) was implemented to investigate the effect of different types and concentrations of elicitors; jasmonic acid (JA) and salicylic acid (SA). Both raised RA levels yet, jasmonic acid (50 µM) has resulted in the highest yield for RA, at 16 mg/g. A nanofiber patch was prepared and characterized in-vitro by the release percentage, drug content, swelling degree, scanning electron microscope, and surface roughness. Then, the anti-wrinkle effect of the patch was tested in a UV wrinkle-induced mouse model. Results: Interestingly, after treatment, there were visibly fewer wrinkles, and the skin was softer than in the untreated control group. This study suggests that the treatment exerted its effect through the Nrf2/Keap1 pathway, which plays a crucial role in cellular antioxidant protective processes. By activating this pathway through boosting Nrf2 and diminishing Keap1 cellular content, the nanofiber patch enhances the production of antioxidant enzymes, such as superoxide dismutase and glutathione peroxidase, enhancesglutathione, and reduces the skin lipid peroxidation, collectively indicating enhanced skin quality. Conclusions: In conclusion, this study highlights the importance of this formula as an anti-wrinkle treatment, and future clinical studies are recommended to further unveil the potential of this formula.

show abstract

Mechanical and tribological properties of epoxy composites reinforced with food-waste fillers

Joszko,

Gzik-Zroska,

Gzik

et al. 2023

Journal of Achievements in Materials and Manufacturing Engineering

View full text Add to dashboard Cite

One of the assumptions of the zero-waste economy is to reduce the amount of industrial waste produced, process it, and recover it without burning or burying it. Citrus peels are among the food wastes that are difficult to recycle. Due to the long time of decomposition and the waxes and fats in their structure, the shells rarely end up in composters and, consequently, are not included in natural fertilisers. The assumptions fit into the research described in the article.The authors investigated the possibility of using ground peels of citrus fruits: grapefruit, key lime, lemon and orange as fillers in composite materials in which the role of the matrix was played by epoxy resin. Composite materials with 2.5, 5 and 10% filler content were prepared. The materials were tested using the tensile, hardness, and abrasive tests using the pin-on-disc method.The research was to answer whether adding citrus waste can change the physicochemical properties of composite materials based on epoxy resin and native resin. Particular attention was paid to the properties that are important from the point of view of engineering applications: mechanical properties and tribological properties.In the face of challenges related to the growing amount of waste from the food industry, joint materials engineering tries to answer whether this waste can be used in the production of composite materials. In several publications from recent years, it has been postulated that used food industry products can be used as fillers for composite materials, as they can, on the one hand, improve specific physicochemical properties of new materials and manage food waste.The tests proved that composite materials with grapefruit and key lime as a filler were characterized by the best tribological properties, mechanical properties, and hardness, which were unchanged or better than the epoxy resin used as a matrix.

show abstract

Polyurethane-Based Nanocomposites for Regenerative Therapies of Cancer Skin Surgery with Low Inflammatory Potential to Healthy Fibroblasts and Keratinocytes In Vitro

Cited by 3 publications

References 62 publications

Surface Engineering of Ti13zr13nb Biomaterial Alloy with Gold Via Laser Melting for Enhanced Biocompatibility and Functional Performance

Surface Engineering of Ti13zr13nb Biomaterial Alloy with Gold Via Laser Melting for Enhanced Biocompatibility and Functional Performance

Quality by Design Approach for the Formulation and Evaluation of Stem Cells Derived Rosmarinic Acid-Loaded Nanofibers as an Anti-Wrinkle Patch: In Vitro and In Vivo Characterizations

Mechanical and tribological properties of epoxy composites reinforced with food-waste fillers

Contact Info

Product

Resources

About