Polyvanadate acts at the level of plasma membranes through α-adrenergic receptor and affects cellular calcium distribution and some oxidation activities

Insulin-like action of novel metformin-containing vanadate as a new antidiabatic drug: Synthesis, characterization and crystal structure of [Metformin-H]2[V2O6] ]·H2O

“…It significantly accelerates glucose removal, thereby reduces hyperglycemia [24,25]. Therefore it was proposed that in the combined treatment vanadate might be forming in vivo very effective antidiabetic agents as suggested in vitro [26]. Second, it has been observed that the therapeutic efficiency of vanadate in Streptozotocin-induced diabetic rats is dependent on the severity of diabetes and the residual pancreatic insulin stores and secretary function [27,28].…”