Polyvinyl Alcohol As an Ophthalmic Vehicle*

Krishna, Narendra; Mitchell, Barbara

doi:10.1016/0002-9394(65)93018-7

Cited by 25 publications

(2 citation statements)

References 7 publications

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“…Tear substitutes are artificial preparations administered locally to supplement the natural tear production. Polyvinyl alcohol is another polymer unrelated to methylcellulose or its derivatives which also prolongs the contact time of aqueous solutions to the cornea (Krishna and Brow, 1964;Nom, 1977). In order to prolong contact time, viscosity enhancing agents like methylcellulose and its different polymers (carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxy ethyl cellulose) have been employed (Swan, 1945;Mims, 1951;Jones and Coop, 1965;Lemp, 1973).…”

Section: Treatmentmentioning

confidence: 99%

Superficial Keratitis

1981

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Section: Treatmentmentioning

confidence: 99%

Superficial Keratitis

1981

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“…(Giannaccini 1989). During the last 50 years, several new opthalmic synthetic and semi-synthetic aqueous polymeric ophthalmic gels have been developed in order to improve the ocular bioavailability of hydro and lipophilic drugs (methylcellulose was introduced in the 1940s (Swan 1945) and polyvinyl alcohol in the 1960s (Krisna & Mitchell 1965)). During the last 20 years, carbomer in variable concentrations has been used as a lubrication and viscosity increasing ocular polymer (e.g.…”

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confidence: 99%

II. An ocular bioavailability comparison in rabbits of prednisolone acetate after repeated topical applications formulated as a high‐viscosity gel and as an aqueous suspension

Johansen

Prause

Rask-Pedersen

1996

Acta Ophthalmologica Scandinavica

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To increase contact time between drug and ocular surface and thus improve the ocular bioavailability, we used the high-viscous, water-soluble polymer carbomer Leogel (carbomer 0.5%). We compared the bioavailability of prednisolone acetate 0.5% given in 1) Leogel using fusidic acid 1% with that obtained using 2) aqueous sulfacetamide sodium 10% as vehicle. We applied the drugs to Copenhagen white rabbits as repeated topical applications (gel preparation: twice daily; aqueous preparation: four times daily) for one week. Dosis regimen was chosen according to earlier investigations (Johansen et al. 1995). Prednisolone concentrations in cornea, conjunctiva and aqueous humour were shown to be higher using the Leogel vehicle than using the aqueous suspension. Fusidic acid and sulfacetamide sodium values were compared with values from a single application (Johansen et al. 1995). Fusidic acid reached higher concentration levels in cornea, conjunctiva and aqueous humour after repeated applications than after a single application. Sulfacetamide sodium concentrations did not rise when applied four times daily for one week. Leogel increases the ocular bioavailability of substance(s) in the gel and allows lower drug concentrations and/or application frequencies.

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Ocular Pharmacology and Toxicology

Ellis¹

1965

Archives of Ophthalmology

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Polyvinyl Alcohol As an Ophthalmic Vehicle*

Cited by 25 publications

References 7 publications

Superficial Keratitis

Superficial Keratitis

II. An ocular bioavailability comparison in rabbits of prednisolone acetate after repeated topical applications formulated as a high‐viscosity gel and as an aqueous suspension

Ocular Pharmacology and Toxicology

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