Polyvinyl alcohol foam: prepackaged emboli for therapeutic embolization

Kerber, CW; Bank, William O.; Horton, JA

doi:10.2214/ajr.130.6.1193

Cited by 45 publications

(15 citation statements)

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“…In order to overcome some of these problems, techniques were developed and tested for maintaining particles in suspension for longer times and to avoid particle aggregation during the application. [6,[10][11][12] It may be said that the best way to avoid particle agglomeration during the application and vessel recanalization after the clinical intervention is to use spherical particles during embolization. Experimental studies reported that spherical particles are injected more easily through the catheter, without causing catheter occlusion.…”

Section: Introductionmentioning

confidence: 99%

Expanded Core/Shell Poly(vinyl acetate)/Poly(vinyl alcohol) Particles for Embolization

Peixoto

Melo

Nele

et al. 2009

Macro Materials & Eng

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An improvement to a previously published suspension polymerization process for the production of spherical core/shell PVAc/PVA particles is described. To increase the settling time of the beads in the suspension, an expansion stage was introduced. The core/shell structure was obtained through the partial hydrolysis of the PVAc. The particle density was manipulated through addition of a solvent during the suspension polymerization stage and posterior expansion of the polymer beads obtained at the end of the process. This technique allows for effective reduction of the density of the final polymer beads. The expansion stage exerts also a beneficial effect on particle drying, avoiding particle aggregation during post‐polymerization processing of the polymer beads.magnified image

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Section: Introductionmentioning

confidence: 99%

Expanded Core/Shell Poly(vinyl acetate)/Poly(vinyl alcohol) Particles for Embolization

Peixoto

Melo

Nele

et al. 2009

Macro Materials & Eng

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“…Na atualidade, embolização intravascular constitui importante estratégia no combate a tumores, aneurismas e malformações vasculares 2 . O rim foi escolhido por ser órgão com vascularização terminal e de apresentação bilateral, o que facilita o estudo comparativo entre o rim submetido à embolização e o rim contra-lateral de controle, não embolizado, e ainda permitir a manutenção das funções vitais do animal.…”

Section: Discussionunclassified

Estudo comparativo da reação inflamatória renal entre álcool de polivinil - flocular e álcool de polivinil + acetato de polivinil - esférico: estudo experimental

Mendes¹,

Chagas

Pinto

et al. 2005

Rev. Col. Bras. Cir.

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; Gaudencio Espinosa,TCBC-RJ 5 RESUMO: Objetivo: Avaliar as características e os efeitos de um agente embólico, disponível comercialmente, consistindo de Polivinil Álcool (PVA) de morfologia flocular, e comparar com um agente esférico, de tecnologia nacional, consistindo de Polivinil Álcool e Polivinil Acetato (PVA + PVAc). Método: Foram utilizadas fêmeas de coelho albino "New Zealand", submetidas à embolização arterial renal. PVA-flocular foi usado em 24 animais, assim como PVA+PVAc-esférico. Seis animais foram utilizados como controle. Todos foram mantidos em cativeiro até a morte, por períodos pós-operatórios de 48 horas, cinco dias, 10 dias e 30 dias. Resultados: Ambos os agentes promoveram oclusão do vaso e infarto do órgão. O estudo microscópico inicial das artérias embolizadas com PVA-flocular, mostra oclusão com trombo e PVA. Os vasos embolizados com PVA+PVAc-esférico, mostram os agentes ocupando praticamente todo o lúmen. No estudo de 30 dias, observa-se absorção do trombo e retração dos agentes de PVAflocular, criando espaços. E com PVA+PVAc-esférico, pode-se observar os agentes circundados por intensa fibrose. Conclusões: Ambas as partículas foram efetivas para causar isquemia tecidual. A reação inflamatória foi mais intensa com PVA+PVAc-esférico que também apresentou grau de penetração maior no sistema vascular (Rev. Col. Bras. Cir. 2005; 32(3): 120-126).

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“…13,19,27 The PVA particles are available in a variety of sizes, ranging from 150 to 1250 microns in diameter, and this substance appears to act by adhering to vessel walls. Furthermore, PVA requires no polymerization, and the risk of incorporating the catheter into the embolic cast is low.…”

Section: Embolic Agentsmentioning

confidence: 99%

The evolution of endovascular treatment for intracranial arteriovenous malformations

Bristol

Albuquerque

McDougall

2006

FOC

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✓ Endovascular therapy for arteriovenous malformations (AVMs) remains a relatively new approach. Beginning in the 1960s with the use of flow-directed techniques for selective embolization, hemodynamic alterations have been used to treat these lesions. In every aspect of treatment, technological advances, including catheters, embolic materials, angiography suites, and pharmacological agents, have improved outcomes while lowering the risk to patients. In this article, the authors review the technical evolution of endovascular AVM therapy. Developments in embolic materials, beginning with foreign bodies and autografts and continuing through to highly engineered contemporary substances, are discussed. Finally, changes in treatment paradigms that have occurred over the years are traced. Within neurosurgery, this specialty has shown some of the fastest growth and development in recent decades. As minimally invasive approaches are embraced in all areas of medicine, it is clear that this treatment modality will continue to be refined.

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Polyvinyl alcohol foam: prepackaged emboli for therapeutic embolization

Cited by 45 publications

References 0 publications

Expanded Core/Shell Poly(vinyl acetate)/Poly(vinyl alcohol) Particles for Embolization

Expanded Core/Shell Poly(vinyl acetate)/Poly(vinyl alcohol) Particles for Embolization

Estudo comparativo da reação inflamatória renal entre álcool de polivinil - flocular e álcool de polivinil + acetato de polivinil - esférico: estudo experimental

The evolution of endovascular treatment for intracranial arteriovenous malformations

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