Polyvinylidene fluoride/hydroxyapatite/β-tricalcium phosphate multifunctional biocomposite: Potentialities for bone tissue engineering

Bonadio, T. G. M.; Freitas, V. F.; Tominaga, Tânia Toyomi; Miyahara, Ricardo Yoshimitsu; Rosso, J. M.; Cótica, L. F.; Baesso, Mauro Luciano; Weinand, W. R.; Santos, I. A.; Guo, Ruyan; Bhalla, A. S.

doi:10.1016/j.cap.2017.02.022

Cited by 29 publications

(15 citation statements)

References 43 publications

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“…The combination of natural CaPs, in general, and BCP, in particular, with other materials, in terms of biocompatible alloys, ceramics, and polymers, represents an alternative way towards the development of new biomaterials with improved performance and mechanical responses with the aim to mimic those of natural bones and tissues [95,105,110].…”

Section: From Fish Discards To Powder Preparationmentioning

confidence: 99%

“…The as-obtained BCP powder was combined with a piezoelectric polymer, polyvinylidene fluoride (PVDF), which is characterized by a high proliferation of osteoblast cells [112]. The composite powder was homogenized, compacted under uniaxial pressure of 114 MPa, and sintered at 170 • C in air for 1 h. The same combination, BCP+PVDF, following a similar protocol, was studied by Bonadio et al [110], who demonstrated the improvement of the bioactivity and consequently their potential use for bone-tissue engineering.…”

Section: From Fish Discards To Powder Preparationmentioning

confidence: 99%

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A Review on Biphasic Calcium Phosphate Materials Derived from Fish Discards

2021

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This review summarizes the results reported on the production of biphasic calcium phosphate (BCP) materials derived from fish wastes (i.e., heads, bones, skins, and viscera), known as fish discards, and offers an in-depth discussion on their promising potential for various applications in many fields, especially the biomedical one. Thus, considerable scientific and technological efforts were recently focused on the capability of these sustainable materials to be transformed into economically attractive and highly valuable by-products. As a consequence of using these wastes, plenty of beneficial social effects, with both economic and environmental impact, will arise. In the biomedical field, there is a strong and continuous interest for the development of innovative solutions for healthcare improvement using alternative materials of biogenic origin. Thus, the orthopedic field has witnessed a significant development due to an increased demand for a large variety of implants, grafts, and/or scaffolds. This is mainly due to the increase of life expectancy and higher frequency of bone-associated injuries and diseases. As a consequence, the domain of bone-tissue engineering has expanded to be able to address a plethora of bone-related traumas and to deliver a viable and efficient substitute to allografts or autografts by combining bioactive materials and cells for bone-tissue ingrowth. Among biomaterials, calcium phosphate (CaP)-based bio-ceramics are widely used in medicine, in particular in orthopedics and dentistry, due to their excellent bioactive, osteoconductive, and osteointegrative characteristics. Recently, BCP materials (synthetic or natural), a class of CaP, which consist of a mixture of two phases, hydroxyapatite (HA) and beta tricalcium phosphate (β-TCP), in different concentrations, gained increased attention due to their superior overall performances as compared to single-phase formulations. Moreover, the exploitation of BCP materials from by-products of fish industry was reported to be a safe, cheap, and simple procedure. In the dedicated literature, there are many reviews on synthetic HA, β-TCP, or BCP materials, but to the best of our knowledge, this is the first collection of results on the effects of processing conditions on the morphological, compositional, structural, mechanical, and biological properties of the fish discard-derived BCPs along with the tailoring of their features for various applications.

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Section: From Fish Discards To Powder Preparationmentioning

confidence: 99%

Section: From Fish Discards To Powder Preparationmentioning

confidence: 99%

A Review on Biphasic Calcium Phosphate Materials Derived from Fish Discards

2021

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“…Piezoelectric polymers such as PVDF, PVDF-TrFE, PLLA, PHB alongside piezoelectric ceramics including BT, LN, LNKN, HA have been assessed for their osteogenic capability [36,37,148]. In particular, the last two years have seen a rise in the number of publications in this area and the promising results obtained point towards a clinical solution to the problem of orthopaedic regeneration [148,234,[264][265][266][267][268][269].…”

Section: The Piezoelectric Mechanism In Tissue Regenerationmentioning

confidence: 99%

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Tandon

Magaz

Balint

et al. 2018

Advanced Drug Delivery Reviews

146

119

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Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment. This review focuses on current state-of-the-art research in electroactive-based materials towards the delivery of drugs and other therapeutic signalling agents for wound care treatment. Future directions and current challenges for developing effective electroactive approach based therapies for wound care are discussed.

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“…27 Piezoelectric and dielectric properties of collagen-nHA composites have been reported by Silva et al 28 These composites are proposed for applications in cellular growth and bone regeneration. Bonadio et al 29 reported a hybrid composite of hydroxyapatite and ⊎-tricalcium phosphate in a PVDF matrix. The composite has been observed to exhibit remnant polarization in a ferroelectric hysteresis loop confirming its piezoelectric nature.…”

Section: Introductionmentioning

confidence: 99%

“…Various elastomer–conductive filler combinations have been reported in the literature as efficient high dielectric materials. Li and co‐workers 30 studied the dielectric properties of PVDF/multiwalled carbon nanotube (MWCNT) composites. Waterborne polyurethane, embedded with TiO 2 nanoparticles, has been demonstrated as a bio‐based electro‐active elastomer for structural health monitoring applications 31 .…”

Section: Introductionmentioning

confidence: 99%

Nanohydroxyapatite embedded blends of ethylene‐co‐vinyl acetate and millable polyurethane as piezoelectric materials: dielectric, viscoelastic and mechanical features

Shafeeq

Karumuthil

Varghese

et al. 2020

Polymer International

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We report the piezoelectric, dielectric and dynamic mechanical features of nanohydroxyapatite (nHA) embedded ethylene-covinyl acetate (EVA)/millable polyurethane (MPU) elastomer blends. The EVA/MPU/nHA systems were prepared by two-roll milling followed by compression moulding. The piezoelectric features were probed by dynamic contact electrostatic force microscopy (EFM).The neat EVA/MPU blend was not found to exhibit ferroelectric properties. However, upon incorporation of nHA, butterfly loops of EFM amplitude signals as well as complementary hysteresis curves were obtained, confirming the introduction of ferropiezoelectric properties. The ferro-piezoelectric features were found to be improved with an increase in nHA loading which recorded highest signals for 8 parts per hundred parts of rubber (phr) loaded composites. The fabricated devices generated a peak voltage of 4.02 V and 4.89 V respectively with 6 phr and 8 phr nHA loaded composites. Electrical properties such as dielectric constant, volume resistivity and loss factor as well as dynamic mechanical properties were examined. The viscoelastic features of the systems support the reinforcing feature with filler loading. TEM analysis of the composites indicated a uniform distribution of filler particles in the blend matrix, complementing the observed ferro-piezoelectric, dielectric and dynamic mechanical properties. The simultaneous modulation of piezoelectric and viscoelastic properties is a preferred feature for fast-responsive dielectric elastomers for their applications in various piezoelectric devices.

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Polyvinylidene fluoride/hydroxyapatite/β-tricalcium phosphate multifunctional biocomposite: Potentialities for bone tissue engineering

Cited by 29 publications

References 43 publications

A Review on Biphasic Calcium Phosphate Materials Derived from Fish Discards

A Review on Biphasic Calcium Phosphate Materials Derived from Fish Discards

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Nanohydroxyapatite embedded blends of ethylene‐co‐vinyl acetate and millable polyurethane as piezoelectric materials: dielectric, viscoelastic and mechanical features

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