Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia.

Aster, Richard H.

doi:10.1172/jci105380

Cited by 799 publications

(486 citation statements)

References 27 publications

Supporting

Mentioning

446

Contrasting

Unclassified

Order By: Relevance

“…Thrombocytopenia is caused by various processes including increased breakdown and pooling of platelets in the spleen (93,94), decreased platelet production (95) and also local accumulation of platelets in the liver (96), where they can interact with leukocytes and contribute to tissue injury and fibrosis. Furthermore, the extent of platelet accumulation in donor liver allografts was reported to correlate with organ function in liver transplant patients (97).…”

Section: Platelet-leukocyte Interactions In Pathologic Conditionsmentioning

confidence: 99%

Measuring and interpreting platelet-leukocyte aggregates

et al. 2018

View full text Add to dashboard Cite

Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct engagement with different types of leukocytes. Indeed, increased platelet-leukocyte aggregates (PLAs) within the circulation and/or locally at the site of inflammation represent markers of many thrombo-inflammatory diseases, such as cardiovascular diseases, acute lung injury, renal and cerebral inflammation. Therefore, measurement of PLAs could provide an attractive and easily accessible prognostic and/or diagnostic tool for many diseases. To measure PLAs in different (patho-)physiological settings in human and animal models flow cytometric and microscopic approaches have been applied. These techniques represent complementary tools to study different aspects relating to the involvement of leukocyte subtypes and molecules, as well as location of PLAs within tissues, dynamics of their interactions and/or dynamic changes in leukocyte and platelet behaviour. This review summarises various approaches to measure and interpret PLAs and discusses potential experimental factors influencing platelet binding to leukocytes. Furthermore, we summarise insights gained from studies regarding the underlying mechanism of platelet-leukocyte interactions and discuss implications of these interactions in health and disease.

show abstract

Section: Platelet-leukocyte Interactions In Pathologic Conditionsmentioning

confidence: 99%

Measuring and interpreting platelet-leukocyte aggregates

et al. 2018

View full text Add to dashboard Cite

show abstract

“…With worsening fibrosis and increasing portal pressures, there is reduced thrombopoetin production and increased platelet sequestration in the spleen. 53,54 Advancing liver fibrosis is also associated with reduced clearance of AST. 55 The APRI test can thus potentially differentiate between those with and without significant fibrosis or cirrhosis.…”

Section: Ast To Platelet Ratio Indexmentioning

confidence: 99%

Diagnosis and Quantitation of Fibrosis

2008

View full text Add to dashboard Cite

“…Además, existe la acción directa de drogas tipo Ristocetina o alcohol. Aparte de la ya mencionada "pseudo trombocitopenia" secundaria al uso de EDTA en donde la vida media de las plaquetas no está alterada; existen los casos del llamado "secuestro esplénico", en donde el almacén esplénico de plaquetas puede incrementarse hasta el 90 % del total, como en la esplenomegalia por hipertensión portal y que rara vez se acompaña de sangrado clínico (4). Otra es la trombocitopenia por dilución como cuando un paciente recibe entre 15 a 20 paquetes de glóbulos rojos (PGR) en 24 horas.…”

Section: Trombocitopenia No Inmuneunclassified

Diagnóstico y tratamiento de la púrpura trombocitopénica inmunológica

Gil¹

2016

Rev Med Hered

View full text Add to dashboard Cite

RESUMENDesde siempre los episodios de sangrado muco-cutáneos, al ser tan evidentes, causan mucha preocupación y zozobra, más aún si ocurren sin causa aparente. La púrpura trombocitopénica suele ser la responsable de estos desagradables sucesos. Esta revisión tiene por objetivo actualizar los conocimientos acerca de la fisiopatología, el diagnóstico y el tratamiento de la púrpura trombocitopénica inmunológica (PTI), una patología hematológica que afecta tanto a niños como a adultos y que se ve con relativa frecuencia en la actividad diaria de un hospital general.PALABRAS CLAVE: Púrpura trombocitopénica, plaquetas, púrpura, autoanticuerpos. (Fuente: DeCS BIREME). SUMMARYThrombocytopenic purpura is mostly responsible for episodes of muco-cutaneous bleeding. This review updates topics on the pathophysiology, diagnosis and treatment of immunologic thrombocytopenic purpura (IPT), an hematologic condition that afects both childern and adults, which is seen relatively frequent in daily practice in a general hospital.KEYWORDS: Purpura thrombocytopenic, Blood platelets, autoantibodies. (Source: MeSH NLM). INTRODUCCIÓNSe entiende por púrpura trombocitopénica inmunológica, la condición clínica que se caracteriza por la disminución de plaquetas en la sangre periférica (SP), mediada por anticuerpos dirigidos contra antígenos plaquetarios que aceleran su destrucción periférica e incluso pueden inhibir la producción de las mismas. La manifestación clínica predominante es la hemorragia muco-cutánea, siendo la más característica la petequia.La mayoría de los casos son considerados primarios denominado Púrpura Trombocitopénica Idiopática (PTI), mientras que otros son secundarios o coexisten con otras condiciones clínicas (PTI secundarios). Esto implica que la PTI es una condición clínico-patológica que involucra desórdenes heterogéneos que tienen en común la producción de auto-anticuerpos contra las plaquetas. Por la misma razón el diagnóstico de PTI resulta siendo de exclusión, dado que no existe una prueba diagnóstica específica.Fisiología: Trombopoyesis (1,2,3) La cuenta normal de plaquetas en sangre periférica (SP) varía entre 150 y 450 x 10 3 /mm 3 . Se denomina trombocitopenia cuando la cuenta plaquetaria es

show abstract

Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia.

Cited by 799 publications

References 27 publications

Measuring and interpreting platelet-leukocyte aggregates

Measuring and interpreting platelet-leukocyte aggregates

Diagnosis and Quantitation of Fibrosis

Diagnóstico y tratamiento de la púrpura trombocitopénica inmunológica

Contact Info

Product

Resources

About