Poor acute outcome in congestive heart failure is associated with increases in the plasma static oxidation–reduction potentials (sORP) in men but not in women

Abstract

Objectives: In congestive heart failure (CHF), men are younger, more likely to have reduced ejection fraction (HF-rEF), and to be diabetic compared to women. Despite this, sex differences in oxidative stress have yet to be explored in CHF. Methods: Data from 67 males and 63 females hospitalized for CHF were collected. Static oxidationreduction potential (sORP), a relative indicator of oxidative stress, and capacity ORP (icORP), a relative indicator of antioxidant capacity, were measured from plasma samples. We examined whether sex modified the relationship between ORP and hospital discharge disposition (poor outcome: death, hospice), along with other demographics, medications, and diagnostic parameters. Results: Males with poor outcomes had higher sORP and icORP values than females (P < 0.05). For those with a good outcome, there were no differences between the sexes (P > 0.05). Males were younger and more likely to have HF-rEF and diabetes. Controlling for these variables did not account for the sex differences in ORP measures. Regardless of sex, higher creatinine was related to higher sORP and icORP, while lower magnesium and potassium were related to higher sORP and icORP, respectively. Discussion: Increases in sORP during CHF are partially affected by sex and acute outcomes, but are also related to variables without sexual biases.

Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement

“…Previous clinical studies showed that sORP is related to outcome and can be used to monitor the amount of oxidative stress in cardiac surgical patients [31] and patients with heart failure, sepsis and trauma [20,25,[32][33][34][35][36][37]. In a previous study, we demonstrated that sORP can be used as a rapid and cheap surrogate marker to monitor changing plasma vitamin C concentrations due to disease and vitamin C supplementation in critically ill patients [23].…”

Estimating Vitamin C Status in Critically Ill Patients with a Novel Point-of-Care Oxidation-Reduction Potential Measurement

“…Moreover, sORP was negatively related to increasing ascorbate concentrations in control solutions of buffer as well [14,17]. Furthermore, ORP was related to the degree of oxidative stress and outcome in cardiac surgical patients [18] and patients with heart failure, sepsis, and trauma [14,19,20,21,22,23,24,25].…”

Unsuitability of the Oxidation-Reduction Potential Measurement for the Quantification of Fecal Redox Status in Inflammatory Bowel Disease

“…More recently, static oxidation-reduction potential (sORP) has been studied for implementation in multiple medical domains. For example, an increase in ORP has been linked to reduced semen quality and to poorer outcomes of congestive heart failure, and it has been demonstrated to be predictive of complications following pediatric cardiac surgery [19,23,24].…”