Poor adherence is a major barrier to the proper treatment of cutaneous leishmaniasis: A case-control field assessment in Iran

Bamorovat, Mehdi; Sharifi, Iraj; Afshari, Setareh Agha Kuchak; Karamoozian, Ali; Tahmouresi, Amirhossein; Heshmatkhah, Amireh; Salarkia, Ehsan; Khosravi, Ahmad; Parizi, Maryam Hakimi; Barghi, Maryam

doi:10.1016/j.ijpddr.2022.11.006

Cited by 7 publications

(16 citation statements)

References 33 publications

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“…In underdeveloped countries, healthcare services are poorly delivered. Available facilities are understaffed with inadequate resources and often incapable of offering appropriate and acceptable healthcare services [ 4 , 21 , 41 ]. Therefore, poor-quality services bring about uncertainty and discourage people from looking at healthcare requests.…”

Section: Major Challengesmentioning

confidence: 99%

“…Besides, they are applied parentally, are often painful, and induce parasite resistance. Application of these drugs by patients often faces treatment failure and further results in chronicity and exacerbation of the disease condition [ 4 , 7 , 48 , 49 ]. Poor treatment adherence is a widespread and ignored phenomenon in the proper treatment of leishmaniasis [ 4 , 21 , 50 , 51 ].…”

Section: Major Challengesmentioning

confidence: 99%

“…Application of these drugs by patients often faces treatment failure and further results in chronicity and exacerbation of the disease condition [ 4 , 7 , 48 , 49 ]. Poor treatment adherence is a widespread and ignored phenomenon in the proper treatment of leishmaniasis [ 4 , 21 , 50 , 51 ]. At present, control of leishmaniasis depends mainly on chemotherapy.…”

Section: Major Challengesmentioning

confidence: 99%

“…Leishmaniasis disproportionately affects inhabitants residing in poverty, mainly in the tropics and subtropics [ 1 , 2 ]. It imposes a major health, social, and economic burden on over one billion people across the globe, notably in low-income nations and the most deprived groups in middle-income countries [ 3 , 4 ]. This complex disease has a substantial devastating impact in terms of morbidity and mortality on people living in the affected countries [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Global Dilemma and Needs Assessment Toward Achieving Sustainable Development Goals in Controlling Leishmaniasis

Bamorovat,

Sharifi,

Khosravi

et al. 2024

J Epidemiol Glob Health

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Leishmaniasis is a disease of poverty that imposes a devastating medical, social, and economic burden on over 1 billion people nationwide. To date, no in-depth study to analyze the major global challenges and needs assessment has been carried out. This investigation aimed to explore a comprehensive narrative review of leishmaniasis’s main challenges and initially highlight obstacles that might impede the implementation of control measures. Also, we propose a specific list of priorities for needs assessment. The presence of socioeconomic factors, multiple clinical and epidemiological forms, various Leishmania species, the complexity of the life cycle, the absence of effective drugs and vaccines, and the lack of efficient vector and reservoir control make this organism unique and sophisticated in playing a tangled role to react tricky with its surrounding environments, despite extensive efforts and implementation of all-inclusive former control measures. These facts indicate that the previous strategic plans, financial support, and basic infrastructures connected to leishmaniasis surveillance are still insufficient. Strengthening the leishmaniasis framework in a context of accelerated programmatic action and intensification of cross-cutting activities along with other neglected tropical diseases (NTDs) is confidently expected to result in greater effectiveness, cost–benefit, and fruitful management. Sensitive diagnostics, effective therapeutics, and efficacious vaccines are vital to accelerating advancement toward elimination, and reducing morbidity/mortality and program costs. Collective actions devoted by all sectors and policy-makers can hopefully overcome technical and operational barriers to guarantee that effective and coordinated implementation plans are sustained to meet the road map for NTDs 2021- 2030 goals.

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Section: Major Challengesmentioning

confidence: 99%

Section: Major Challengesmentioning

confidence: 99%

Section: Major Challengesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Global Dilemma and Needs Assessment Toward Achieving Sustainable Development Goals in Controlling Leishmaniasis

Bamorovat,

Sharifi,

Khosravi

et al. 2024

J Epidemiol Glob Health

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“…Leishmaniasis is prevalent in over 100 countries, affecting approximately 350 million individuals, with 12 million of them being infected, primarily in tropical and subtropical regions, particularly in Africa [ 3 , 4 ]. Thus, the impact of leishmaniasis on this continent is significant, often impacting vulnerable populations and being exacerbated by numerous risk factors, deficiencies in diagnostic approaches, and the absence of effective treatments [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family

Abdoul-Latif,

Oumaskour,

Abdallah

et al. 2024

Pharmaceuticals

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Leishmaniasis in Africa, which has been designated as a priority neglected tropical disease by various global organizations, exerts its impact on millions of individuals, primarily concentrated within this particular region of the world. As a result of the progressively grave epidemiological data, numerous governmental sectors and civil organizations have concentrated their endeavors on this widespread outbreak with the objective of devising appropriate remedies. This comprehensive examination delves into multiple facets of this parasitic ailment, scrutinizing the associated perils, diagnostic intricacies, and deficiencies within the existing therapeutic protocols. Despite the established efficacy of current treatments, they are not immune to deleterious incidents, particularly concerning toxicity and the emergence of parasitic resistance, thus accentuating the necessity of exploring alternative avenues. Consequently, this research not only encompasses conventional therapeutic approaches, but also extends its scope to encompass complementary and alternative medicinal techniques, thereby striving to identify innovative solutions. A particularly auspicious dimension of this study lies in the exploration of natural substances and by-products derived from some brown algae of the Sargassaceae family. These resources possess the potential to assume a pivotal role in the management of leishmaniasis.

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Looking through the lens of social science approaches: A scoping review of leishmaniases and Chagas disease research

Nogueira de Brito,

Tanner,

Runk

et al. 2024

Acta Tropica

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Poor adherence is a major barrier to the proper treatment of cutaneous leishmaniasis: A case-control field assessment in Iran

Cited by 7 publications

References 33 publications

Global Dilemma and Needs Assessment Toward Achieving Sustainable Development Goals in Controlling Leishmaniasis

Global Dilemma and Needs Assessment Toward Achieving Sustainable Development Goals in Controlling Leishmaniasis

Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family

Looking through the lens of social science approaches: A scoping review of leishmaniases and Chagas disease research

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